Clinical features presented to primary care prior to diagnosis of giant cell arteritis: an electronic health records study (2021)
Thesis
Barnett, L. A. (2021). Clinical features presented to primary care prior to diagnosis of giant cell arteritis: an electronic health records study. (Thesis). Keele University

Background: Giant cell arteritis (GCA) is the most common form of medium and large vessel vasculitis. This condition is associated with serious complications, such as blindness if left untreated, and is therefore considered a medical emergency. Howev... Read More about Clinical features presented to primary care prior to diagnosis of giant cell arteritis: an electronic health records study.

Investigating the characteristics and functions of extracellular vesicles from umbilical cord mesenchymal stem cells (2021)
Thesis
Hyland, M. (2021). Investigating the characteristics and functions of extracellular vesicles from umbilical cord mesenchymal stem cells. (Thesis). Keele University

Rheumatoid Arthritis (RA) is a chronic autoimmune disease which is characterised by a loss of immune tolerance, and an infiltration of immune cells into joints causing inflammation. Current pharmaceutical treatments for RA have adverse side effects a... Read More about Investigating the characteristics and functions of extracellular vesicles from umbilical cord mesenchymal stem cells.

The development of individualised work absence prediction models in patients with neck and/or low back pain (2021)
Presentation / Conference
Wynne-Jones, G., Archer, L., Snell, K., Stynes, S., Dunn, K., Foster, N., …Hill, J. (2021, December). The development of individualised work absence prediction models in patients with neck and/or low back pain. Presented at Virtual Physiotherapy UK 2020 Conference

Implementation of a novel stratified PAthway of CarE for common musculoskeletal (MSK) conditions in primary care: protocol for a multicentre pragmatic randomised controlled trial (the PACE MSK trial) (2021)
Journal Article
(2021). Implementation of a novel stratified PAthway of CarE for common musculoskeletal (MSK) conditions in primary care: protocol for a multicentre pragmatic randomised controlled trial (the PACE MSK trial). BMJ Open, https://doi.org/10.1136/bmjopen-2021-057705

Introduction Musculoskeletal (MSK) conditions constitute the highest burden of disease globally, with healthcare services often utilised inappropriately and overburdened. The aim of this trial is to evaluate the effectiveness of a novel clinical PAth... Read More about Implementation of a novel stratified PAthway of CarE for common musculoskeletal (MSK) conditions in primary care: protocol for a multicentre pragmatic randomised controlled trial (the PACE MSK trial).

European Society for Radiotherapy and Oncology Advisory Committee in Radiation Oncology Practice consensus recommendations on patient selection and dose and fractionation for external beam radiotherapy in early breast cancer. (2021)
Journal Article
Meattini, I., Becherini, C., Boersma, L., Kaidar-Person, O., Nader Marta, G., Montero, A., …Coles, C. E. (2022). European Society for Radiotherapy and Oncology Advisory Committee in Radiation Oncology Practice consensus recommendations on patient selection and dose and fractionation for external beam radiotherapy in early breast cancer. Lancet Oncology, 23(1), e21 - e31. https://doi.org/10.1016/S1470-2045%2821%2900539-8

High-quality randomised clinical trials testing moderately fractionated breast radiotherapy have clearly shown that local control and survival is at least as effective as with 2 Gy daily fractions with similar or reduced normal tissue toxicity. Fewer... Read More about European Society for Radiotherapy and Oncology Advisory Committee in Radiation Oncology Practice consensus recommendations on patient selection and dose and fractionation for external beam radiotherapy in early breast cancer..

New developments in osteoarthritis pharmacological therapies. (2021)
Journal Article
(2021). New developments in osteoarthritis pharmacological therapies. Rheumatology, vi1 - vi11. https://doi.org/10.1093/rheumatology/keab679

OA is an increasingly common, painful condition with complex aetiology and limited therapies. Approaches to expanding our therapeutic armamentarium have included repurposing existing therapies used for other rheumatological conditions, modifying exis... Read More about New developments in osteoarthritis pharmacological therapies..

Development of an optimised physiotherapist-led treatment protocol for lateral elbow tendinopathy: a consensus study using an online nominal group technique (2021)
Journal Article
Bateman, M., Saunders, B., Littlewood, C., & Hill, J. (2021). Development of an optimised physiotherapist-led treatment protocol for lateral elbow tendinopathy: a consensus study using an online nominal group technique. BMJ Open, 11(12), Article e053841. https://doi.org/10.1136/bmjopen-2021-053841

OBJECTIVES: There are a wide range of physiotherapy treatment options for people with lateral elbow tendinopathy (LET); however, previous studies have reported inconsistent approaches to treatment and a lack of evidence demonstrating clinical effecti... Read More about Development of an optimised physiotherapist-led treatment protocol for lateral elbow tendinopathy: a consensus study using an online nominal group technique.

Therapeutic Effects of Hypoxic and Pro-Inflammatory Priming of Mesenchymal Stem Cell-Derived Extracellular Vesicles in Inflammatory Arthritis (2021)
Journal Article
Kay, A. G., Roach, P., Morgan, R., Lodge, R., Hyland, M., Piccinini, A. M., …Treadwell, K. (2021). Therapeutic Effects of Hypoxic and Pro-Inflammatory Priming of Mesenchymal Stem Cell-Derived Extracellular Vesicles in Inflammatory Arthritis. International Journal of Molecular Sciences, 23(1), 126 - 126. https://doi.org/10.3390/ijms23010126

<jats:p>Mesenchymal stem cells (MSCs) immunomodulate inflammatory responses through paracrine signalling, including via secretion of extracellular vesicles (EVs) in the cell secretome. We evaluated the therapeutic potential of MSCs-derived small EVs... Read More about Therapeutic Effects of Hypoxic and Pro-Inflammatory Priming of Mesenchymal Stem Cell-Derived Extracellular Vesicles in Inflammatory Arthritis.

Decision making in percutaneous coronary intervention in patients with cancer: balancing ischaemic and bleeding risk. (2021)
Journal Article
Mamas. (2021). Decision making in percutaneous coronary intervention in patients with cancer: balancing ischaemic and bleeding risk. https://doi.org/10.1093/eurheartj/ehab403

Risk for Myocardial Infarction Following 5-Fluorouracil Treatment in Patients With Gastrointestinal Cancer: A Nationwide Registry-Based Study. (2021)
Journal Article
Mamas. (2021). Risk for Myocardial Infarction Following 5-Fluorouracil Treatment in Patients With Gastrointestinal Cancer: A Nationwide Registry-Based Study. https://doi.org/10.1016/j.jaccao.2021.11.001

Background: Myocardial infarction is a cardiac adverse event associated with 5-fluorouracil (5-FU). There are limited data on the incidence, risk, and prognosis of 5-FU-associated myocardial infarction. Objectives: The aim of this study was to examin... Read More about Risk for Myocardial Infarction Following 5-Fluorouracil Treatment in Patients With Gastrointestinal Cancer: A Nationwide Registry-Based Study..

Co-designing an Adaption of a Mobile App to Enhance Communication, Safety, and Well-being Among People Living at Home With Early-Stage Dementia: Protocol for an Exploratory Multiple Case Study (2021)
Journal Article
(2021). Co-designing an Adaption of a Mobile App to Enhance Communication, Safety, and Well-being Among People Living at Home With Early-Stage Dementia: Protocol for an Exploratory Multiple Case Study. JMIR Research Protocols, e19543 - e19543

<jats:sec> <jats:title>Background</jats:title> <jats:p>There is a growing interest in using mobile apps to support communication, safety, and well-being. Evidence directly from people with dementia regarding the usability, usefulness, and relevance o... Read More about Co-designing an Adaption of a Mobile App to Enhance Communication, Safety, and Well-being Among People Living at Home With Early-Stage Dementia: Protocol for an Exploratory Multiple Case Study.

Effects of an Online Education Program on Physical Therapists' Confidence in Weight Management for People With Osteoarthritis: A Randomized Controlled Trial (2021)
Journal Article
Allison, K., Jones, S., Hinman, R. S., Briggs, A. M., Sumithran, P., Quicke, J., …Bennell, K. (2021). Effects of an Online Education Program on Physical Therapists' Confidence in Weight Management for People With Osteoarthritis: A Randomized Controlled Trial. Arthritis Care and Research, 75(4), 835-847. https://doi.org/10.1002/acr.24828

OBJECTIVE: Evaluate effects of an online education program about weight management for osteoarthritis on physiotherapists' self-reported confidence in knowledge and skills in weight management, and attitudes toward obesity.

METHOD: A two-group ran... Read More about Effects of an Online Education Program on Physical Therapists' Confidence in Weight Management for People With Osteoarthritis: A Randomized Controlled Trial.

The experience of blood glucose monitoring in people with type 2 diabetes mellitus (T2DM) (2021)
Journal Article
Stedman, M., Rea, R., Duff, C. J., Livingston, M., McLoughlin, K., Wong, L., …Heald, A. H. (2022). The experience of blood glucose monitoring in people with type 2 diabetes mellitus (T2DM). https://doi.org/10.1002/edm2.302

BACKGROUND: Finger prick blood glucose (BG) monitoring remains a mainstay of management in people with type 2 diabetes (T2DM) who take sulphonylurea (SU) drugs or insulin. We recently examined patient experience of BG monitoring in people with type 1... Read More about The experience of blood glucose monitoring in people with type 2 diabetes mellitus (T2DM).

Suicide and other causes of death among working-age and older adults in the year after discharge from in-patient mental healthcare in England: matched cohort study (2021)
Journal Article
Musgrove, R., Carr, M., Chew-Graham, C., Mughal, F., Kapur, N., Ashcroft, D., & Webb, R. (2021). Suicide and other causes of death among working-age and older adults in the year after discharge from in-patient mental healthcare in England: matched cohort study. British Journal of Psychiatry, 1 - 8. https://doi.org/10.1192/bjp.2021.176

<jats:sec id="S0007125021001768_sec_a1"> <jats:title>Background</jats:title> <jats:p>Evidence for risk of dying by suicide and other causes following discharge from in-patient psychiatric care throughout adulthood is sparse.</jats:p> </jats:sec> <jat... Read More about Suicide and other causes of death among working-age and older adults in the year after discharge from in-patient mental healthcare in England: matched cohort study.

Addressing disparities of care in non-ST-segment elevation myocardial infarction (NSTEMI) patients without standard modifiable risk factors: insights from a nationwide cohort study (2021)
Journal Article
Rashid, Mamas, & Nolan. (2021). Addressing disparities of care in non-ST-segment elevation myocardial infarction (NSTEMI) patients without standard modifiable risk factors: insights from a nationwide cohort study. European Journal of Preventive Cardiology, 1084-1092. https://doi.org/10.1093/eurjpc/zwab200

Background: The importance of standard modifiable cardiovascular risk factors (SMuRFs) in preventing non-ST segment myocardial infarction (NSTEMI) is established. However, NSTEMI may present in the absence of SMuRFs, and little is known about their o... Read More about Addressing disparities of care in non-ST-segment elevation myocardial infarction (NSTEMI) patients without standard modifiable risk factors: insights from a nationwide cohort study.

Efficient and safe correction of hemophilia A by lentiviral vector-transduced BOECs in an implantable device (2021)
Journal Article
Wragg, N. (2021). Efficient and safe correction of hemophilia A by lentiviral vector-transduced BOECs in an implantable device. Molecular Therapy - Methods and Clinical Development, 551-566. https://doi.org/10.1016/j.omtm.2021.10.015

Hemophilia A (HA) is a rare bleeding disorder caused by deficiency/dysfunction of the FVIII protein. As current therapies based on frequent FVIII infusions are not a definitive cure, long-term expression of FVIII in endothelial cells through lentivir... Read More about Efficient and safe correction of hemophilia A by lentiviral vector-transduced BOECs in an implantable device.

Misdiagnosis of aortic dissection: A systematic review of the literature (2021)
Journal Article
Mallen. (2021). Misdiagnosis of aortic dissection: A systematic review of the literature. American Journal of Emergency Medicine, https://doi.org/10.1016/j.ajem.2021.11.047

Background
Aortic dissection is a rare but potentially catastrophic condition. Misdiagnosis of aortic dissection is not uncommon as symptoms can overlap with other diagnoses.

Objective
We conducted a systematic review to better understand the fa... Read More about Misdiagnosis of aortic dissection: A systematic review of the literature.

Radiographic validation of a self-report instrument for hallux valgus (2021)
Journal Article
Gupta, V., Lingham, A., Marshall, M., Rathod‐Mistry, T., Menz, H. B., & Roddy, E. (2022). Radiographic validation of a self-report instrument for hallux valgus. Musculoskeletal Care, 20(2), 383-389. https://doi.org/10.1002/msc.1604

Background Hallux valgus (HV) is a common condition causing substantial morbidity. Radiographic assessment is the gold standard for grading severity but is not always feasible in clinical/research settings. HV line-drawings, consisting of five drawin... Read More about Radiographic validation of a self-report instrument for hallux valgus.

How do people with knee osteoarthritis perceive and manage flares? A qualitative study (2021)
Journal Article
Parry, E., Dikomitis, L., Peat, G., & Chew-Graham, C. (2022). How do people with knee osteoarthritis perceive and manage flares? A qualitative study. British Journal of General Practice Open (BJGP Open), 6(2), BJGPO.2021.0086 - BJGPO.2021.0086. https://doi.org/10.3399/BJGPO.2021.0086

Background Acute flares in people with osteoarthritis (OA) are poorly understood. There is uncertainty around the nature of flares, their impact, and how these are managed.

Aim To explore understandings and experiences of flares in people with kne... Read More about How do people with knee osteoarthritis perceive and manage flares? A qualitative study.

Mobilizing physiotherapy knowledge: Understanding the best evidence and barriers to implementation of hydrotherapy for musculoskeletal disease. (2021)
Journal Article
Dziedzic. (2021). Mobilizing physiotherapy knowledge: Understanding the best evidence and barriers to implementation of hydrotherapy for musculoskeletal disease. Physiotherapy Theory and Practice, 1 - 8. https://doi.org/10.1080/09593985.2021.2010847

OBJECTIVES: To explore two linked strategies to highlight the best current available evidence for hydrotherapy and to explore the barriers and enablers to mobilizing this evidence into practice. METHOD: Phase 1: The best published evidence for hydrot... Read More about Mobilizing physiotherapy knowledge: Understanding the best evidence and barriers to implementation of hydrotherapy for musculoskeletal disease..