Protocol for CLASSIC PBB: comparison of lower airway sampling strategies in children with protracted bacterial bronchitis (2022)
Journal Article
Gilchrist, F., Aspey, M., Bowler, R., Brodlie, M., Desai, S., Harris, C., …Carroll, W. D. (2022). Protocol for CLASSIC PBB: comparison of lower airway sampling strategies in children with protracted bacterial bronchitis. BMJ Paediatrics Open, e001722 - e001722. https://doi.org/10.1136/bmjpo-2022-001722

Background Protracted bacterial bronchitis (PBB) is an endobronchial infection and a the most common cause of chronic wet cough in young children. It is treated with antibiotics, which can only be targeted if the causative organism is known. As most... Read More about Protocol for CLASSIC PBB: comparison of lower airway sampling strategies in children with protracted bacterial bronchitis.

Acceptability and engagement amongst patients on oral and intravenous bisphosphonates for the treatment of osteoporosis in older adults (2022)
Journal Article
Narayanasamy, M., Bishop, S., Sahota, O., Paskins, Z., Gittoes, N., & Langley, T. (2022). Acceptability and engagement amongst patients on oral and intravenous bisphosphonates for the treatment of osteoporosis in older adults. Age and ageing, https://doi.org/10.1093/ageing/afac255

Background: Osteoporosis is common in older adults leading to fragility fractures at enormous individual and economic cost. Improving long-term adherence with bisphosphonate treatments reduces fracture risk, but adherence rates for first line oral bi... Read More about Acceptability and engagement amongst patients on oral and intravenous bisphosphonates for the treatment of osteoporosis in older adults.

Effects of the COVID-19 pandemic on secondary care for cardiovascular disease in the UK: an electronic health record analysis across three countries. (2022)
Journal Article
Wright, F. L., Cheema, K., Goldacre, R., Hall, N., Herz, N., Islam, N., …Banerjee, A. (2023). Effects of the COVID-19 pandemic on secondary care for cardiovascular disease in the UK: an electronic health record analysis across three countries. European Heart Journal - Quality of Care and Clinical Outcomes, 9(4), 377-388. https://doi.org/10.1093/ehjqcco/qcac077

Background
Although morbidity and mortality from COVID-19 have been widely reported, the indirect effects of the pandemic beyond 2020 on other major diseases and health service activity have not been well described.

Methods and results
Analyses... Read More about Effects of the COVID-19 pandemic on secondary care for cardiovascular disease in the UK: an electronic health record analysis across three countries..

Degenerative Cervical Myelopathy: A Case Report of Delayed Diagnosis in a Younger Man (2022)
Journal Article
(2022). Degenerative Cervical Myelopathy: A Case Report of Delayed Diagnosis in a Younger Man. https://doi.org/10.2519/josptcases.2022.11088

BACKGROUND: Degenerative cervical myelopathy is most caused by degenerative cervical stenosis in an over 55-year age group. However, it may occur in younger ages, most commonly due to large cervical disc protrusions.

CASE PRESENTATION: The case re... Read More about Degenerative Cervical Myelopathy: A Case Report of Delayed Diagnosis in a Younger Man.

Palliative Care Use in Patients With Acute Myocardial Infarction and Do-Not-Resuscitate Status From a Nationwide Inpatient Cohort. (2022)
Journal Article
Mamas. (2022). Palliative Care Use in Patients With Acute Myocardial Infarction and Do-Not-Resuscitate Status From a Nationwide Inpatient Cohort. Mayo Clinic Proceedings, 98(4), 569-578. https://doi.org/10.1016/j.mayocp.2022.08.018

OBJECTIVE: To examine the predictors, treatments, and outcomes of the use of palliative care in patients hospitalized with acute myocardial infarction (AMI) who had a do-not-resuscitate (DNR) order.

PATIENTS AND METHODS: Using the National (Natio... Read More about Palliative Care Use in Patients With Acute Myocardial Infarction and Do-Not-Resuscitate Status From a Nationwide Inpatient Cohort..

The Need for Breathing Training Techniques: The Elephant in the Heart Failure Cardiac Rehabilitation Room: A Randomized Controlled Trial (2022)
Journal Article
Farghaly, A., Fitzsimons, D., Bradley, J., Sedhom, M., & Atef, H. (in press). The Need for Breathing Training Techniques: The Elephant in the Heart Failure Cardiac Rehabilitation Room: A Randomized Controlled Trial. International Journal of Environmental Research and Public Health, 19(22), Article 14694. https://doi.org/10.3390/ijerph192214694

Cardiometabolic risk profiles in a Sri Lankan twin and singleton sample. (2022)
Journal Article
(2022). Cardiometabolic risk profiles in a Sri Lankan twin and singleton sample. PloS one, e0276647 - ?

INTRODUCTION: Prevention of cardiovascular disease and diabetes is a priority in low- and middle-income countries, especially in South Asia where these are leading causes of morbidity and mortality. The metabolic syndrome is a tool to identify cardio... Read More about Cardiometabolic risk profiles in a Sri Lankan twin and singleton sample..

Screening for atrial fibrillation in the elderly: A network meta-analysis of randomized trials. (2022)
Journal Article
Elbadawi, A., Sedhom, R., Gad, M., Hamed, M., Elwagdy, A., Barakat, A. F., …Jneid, H. (2022). Screening for atrial fibrillation in the elderly: A network meta-analysis of randomized trials. European Journal of Internal Medicine, 105, 38 - 45. https://doi.org/10.1016/j.ejim.2022.07.015

BACKGROUND: Randomized controlled trials (RCTs) investigating the optimal screening strategy for atrial fibrillation (AF) have yielded conflicting results.

OBJECTIVE: To examine the comparative efficacy of different AF screening strategies in old... Read More about Screening for atrial fibrillation in the elderly: A network meta-analysis of randomized trials..

Derivation and External Validation of a Clinical Model to Predict Heart Failure Onset in Patients with Incident Diabetes (2022)
Journal Article
Mamas. (2022). Derivation and External Validation of a Clinical Model to Predict Heart Failure Onset in Patients with Incident Diabetes. Diabetes Care, 2737-2745. https://doi.org/10.2337/dc22-0894

OBJECTIVE

Heart failure (HF) often develops in patients with diabetes and is recognized for its role in increased cardiovascular morbidity and mortality in this population. Most existing models predict risk in patients with prevalent rather than i... Read More about Derivation and External Validation of a Clinical Model to Predict Heart Failure Onset in Patients with Incident Diabetes.

Imaging Breast Microcalcifications Using Dark-Field Signal in Propagation-Based Phase-Contrast Tomography. (2022)
Journal Article
Aminzadeh, A., Arhatari, B., Maksimenko, A., Hall, C., Hausermann, D., Peele, A., …Lockie, D. (2022). Imaging Breast Microcalcifications Using Dark-Field Signal in Propagation-Based Phase-Contrast Tomography. IEEE Transactions on Medical Imaging, 2980 - 2990. https://doi.org/10.1109/TMI.2022.3175924

Breast microcalcifications are an important primary radiological indicator of breast cancer. However, microcalcification classification and diagnosis may be still challenging for radiologists due to limitations of the standard 2D mammography techniqu... Read More about Imaging Breast Microcalcifications Using Dark-Field Signal in Propagation-Based Phase-Contrast Tomography..

A metabolomic analysis of cardiac metabolism in a human model of early myocardial ischaemia (2022)
Thesis
Chacko, S. M. (2022). A metabolomic analysis of cardiac metabolism in a human model of early myocardial ischaemia. (Thesis). Keele University

Introduction: Acute myocardial ischaemia and the transition from reversible to irreversible myocardial injury are associated with abnormal metabolic patterns. Advances in metabolomics have extended our capabilities to define these metabolic perturbat... Read More about A metabolomic analysis of cardiac metabolism in a human model of early myocardial ischaemia.

Socioeconomic Factors and their Impact on Access and Use of Coronary and Structural Interventions (2022)
Journal Article
Bullock-Palmer, R. P., Bravo-Jaimes, K., Mamas, M. A., & Grines, C. L. (2022). Socioeconomic Factors and their Impact on Access and Use of Coronary and Structural Interventions. European Cardiology Review, 17, https://doi.org/10.15420/ecr.2022.23

In the past few decades, the accelerated improvement in technology has allowed the development of new and effective coronary and structural heart disease interventions. There has been inequitable patient access to these advanced therapies and signifi... Read More about Socioeconomic Factors and their Impact on Access and Use of Coronary and Structural Interventions.

Association of Gout Polygenic Risk Score with Age at Disease Onset and Tophaceous Disease in European and Polynesian Men with Gout. (2022)
Journal Article
Roddy, E. (2022). Association of Gout Polygenic Risk Score with Age at Disease Onset and Tophaceous Disease in European and Polynesian Men with Gout. Arthritis and Rheumatology, 75(5), 816-825. https://doi.org/10.1002/art.42393

OBJECTIVE: To determine whether a gout polygenic risk score (PRS) associates with age at gout onset and tophaceous disease in European (EUR), East Polynesian (EP), and West Polynesian (WP) men/women with gout.

METHODS: A 19-variant gout PRS was p... Read More about Association of Gout Polygenic Risk Score with Age at Disease Onset and Tophaceous Disease in European and Polynesian Men with Gout..

Patient and public involvement in implementation of evidence-based guidance for musculoskeletal conditions: a scoping review of current advances and gaps (2022)
Journal Article
Babatunde, O. O., Dawson, S., Brammar, J., Parton, L., Dziedzic, K., & Adebajo, A. O. (2022). Patient and public involvement in implementation of evidence-based guidance for musculoskeletal conditions: a scoping review of current advances and gaps. BMC Rheumatology, 6, Article 84. https://doi.org/10.1186/s41927-022-00310-x

Advances in musculoskeletal (MSK) research have been successfully curated into widely endorsed evidence-based recommendations and guidelines. However, there continues to exist significant variations in care and quality of care, and the global health... Read More about Patient and public involvement in implementation of evidence-based guidance for musculoskeletal conditions: a scoping review of current advances and gaps.

Intermediate care in caring for dementia, the point of view of general practitioners: A key informant survey across Europe. (2022)
Journal Article
Dibao-Dina, C., Oger, C., Foley, T., Torzsa, P., Lazic, V., Kreitmayer Peštiae, S., …Petrazzuoli, F. (2022). Intermediate care in caring for dementia, the point of view of general practitioners: A key informant survey across Europe. Frontiers in Medicine, https://doi.org/10.3389/fmed.2022.1016462

Background: Intermediate care is often defined as healthcare occurring somewhere between traditional primary (community) and secondary (hospital) care settings. High quality intermediate care is important in dementia, may prevent caregiver burnout an... Read More about Intermediate care in caring for dementia, the point of view of general practitioners: A key informant survey across Europe..

Rheumatoid arthritis, psoriatic arthritis, and axial spondyloarthritis epidemiology in England from 2004 to 2020: An observational study using primary care electronic health record data (2022)
Journal Article
Scott, I. C., Whittle, R., Bailey, J., Twohig, H., Hider, S., Mallen, C., …Jordan, K. (2022). Rheumatoid arthritis, psoriatic arthritis, and axial spondyloarthritis epidemiology in England from 2004 to 2020: An observational study using primary care electronic health record data. The Lancet Regional Health Europe, 23, Article 100519. https://doi.org/10.1016/j.lanepe.2022.100519

Background: Contemporary data on rheumatoid arthritis (RA), psoriatic arthritis (PsA) and axial spondyloarthritis (SpA) epidemiology in England are lacking. This knowledge is crucial to planning healthcare services. We updated algorithms defining pat... Read More about Rheumatoid arthritis, psoriatic arthritis, and axial spondyloarthritis epidemiology in England from 2004 to 2020: An observational study using primary care electronic health record data.

Loss of cytoskeletal proteostasis links dysregulation of cell size and mechanotransduction in mesenchymal stem cell senescence (2022)
Journal Article
Mallikarjun, V., Dobre, O., Jackson, M., Kidd, M., Llewellyn, J., Gilbert, H., …Swift, J. (2022). Loss of cytoskeletal proteostasis links dysregulation of cell size and mechanotransduction in mesenchymal stem cell senescence. arXiv,

ABSTRACT Tissues are maintained by homeostatic feedback mechanisms where cells respond to, but also modify, the chemical and mechanical properties of the surrounding extracellular matrix. Mesenchymal stem cells (MSCs) resident in the marrow niche exp... Read More about Loss of cytoskeletal proteostasis links dysregulation of cell size and mechanotransduction in mesenchymal stem cell senescence.

Exploring the feasibility, acceptability and value of volunteer peer mentors in supporting self-management of osteoarthritis: a qualitative evaluation (2022)
Journal Article
C. Lavender, E., Dusabe-Richards, E., Anderson, A. M., Antcliff, D., McGowan, L., Conaghan, P. G., …McHugh, G. A. (2022). Exploring the feasibility, acceptability and value of volunteer peer mentors in supporting self-management of osteoarthritis: a qualitative evaluation. Disability and Rehabilitation, 6314 - 6324. https://doi.org/10.1080/09638288.2021.1964625

Background
Hip and knee osteoarthritis (OA) affect a large and growing proportion of the population. Treatment options are typically conservative making self-management a priority. Using trained peers to support individuals with OA has potential to... Read More about Exploring the feasibility, acceptability and value of volunteer peer mentors in supporting self-management of osteoarthritis: a qualitative evaluation.

Prediction Models to Estimate the Future Risk of Osteoarthritis in the General Population: A Systematic Review (2022)
Journal Article
Appleyard, T., Thomas, M. J., Antcliff, D., & Peat, G. (2022). Prediction Models to Estimate the Future Risk of Osteoarthritis in the General Population: A Systematic Review. Arthritis Care and Research, 75(7), 1481-1493. https://doi.org/10.1002/acr.25035

OBJECTIVE: To evaluate the performance and applicability of multivariable prediction models for osteoarthritis (OA). METHODS: Systematic review and narrative synthesis using three databases (EMBASE, PubMed, Web of Science; inception to December 2021)... Read More about Prediction Models to Estimate the Future Risk of Osteoarthritis in the General Population: A Systematic Review.

Cardiovascular outcomes and trends of Transcatheter vs. Surgical aortic valve replacement among octogenarians with heart failure: A Propensity Matched national cohort analysis. (2022)
Journal Article
Mamas, & Rashid. (2022). Cardiovascular outcomes and trends of Transcatheter vs. Surgical aortic valve replacement among octogenarians with heart failure: A Propensity Matched national cohort analysis

Background: Heart failure (HF) is a complex clinical syndrome with symptoms and signs that result from any structural or functional impairment of ventricular filling or ejection of blood. Limited data is available regarding the in-hospital outcomes o... Read More about Cardiovascular outcomes and trends of Transcatheter vs. Surgical aortic valve replacement among octogenarians with heart failure: A Propensity Matched national cohort analysis..