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264th ENMC International Workshop: Multi-system involvement in spinal muscular atrophy Hoofddorp, the Netherlands, November 19th – 21st 2021 (2022)
Journal Article
Detering, N. T., Zambon, A., Hensel, N., Kothary, R., Swoboda, K., Gillingwater, T. H., …Bowerman. (2022). 264th ENMC International Workshop: Multi-system involvement in spinal muscular atrophy Hoofddorp, the Netherlands, November 19th – 21st 2021. Neuromuscular Disorders, 32(8), 697-705. https://doi.org/10.1016/j.nmd.2022.06.005

The potential role of community pharmacy staff in reducing patient delay in consulting with symptoms of rheumatoid arthritis: a qualitative study. (2022)
Journal Article
Ismail, N., Sandhu, K., Mallen, C., Stack, R., Pontefract, S., Simons, G., …Falahee, M. (2022). The potential role of community pharmacy staff in reducing patient delay in consulting with symptoms of rheumatoid arthritis: a qualitative study. BMC Rheumatology, 50 - ?. https://doi.org/10.1186/s41927-022-00280-0

BACKGROUND: Rheumatoid arthritis (RA) is a chronic inflammatory arthritis which can cause joint damage and reduced quality of life. Early treatment of RA within 3 months of symptom onset is associated with improved clinical outcomes. However, this wi... Read More about The potential role of community pharmacy staff in reducing patient delay in consulting with symptoms of rheumatoid arthritis: a qualitative study..

Clinical Outcomes of Percutaneous Coronary Intervention for Bifurcation Lesions According to Medina Classification (2022)
Journal Article
Mamas, M. A., Mohamed, M. O., Lamellas, P., Roguin, A., Oemrawsingh, R. M., Ijsselmuiden, A. J. J., …Roffi, M. (2022). Clinical Outcomes of Percutaneous Coronary Intervention for Bifurcation Lesions According to Medina Classification. Journal of the American Heart Association, 11(17), Article e025459. https://doi.org/10.1161/JAHA.122.025459

Background Coronary bifurcation lesions (CBLs) are frequently encountered in clinical practice and are associated with worse outcomes after percutaneous coronary intervention. However, there are limited data around the prognostic impact of different... Read More about Clinical Outcomes of Percutaneous Coronary Intervention for Bifurcation Lesions According to Medina Classification.

The Proteome Signatures of Fibroblasts from Patients with Severe, Intermediate and Mild Spinal Muscular Atrophy Show Limited Overlap (2022)
Journal Article
Brown, S. J., Kline, R. A., Synowsky, S. A., Shirran, S. L., Holt, I., Sillence, K. A., …Fuller, H. R. (2022). The Proteome Signatures of Fibroblasts from Patients with Severe, Intermediate and Mild Spinal Muscular Atrophy Show Limited Overlap. Cells, 11(17), https://doi.org/10.3390/cells11172624

Most research to characterise the molecular consequences of spinal muscular atrophy (SMA) has focused on SMA I. Here, proteomic profiling of skin fibroblasts from severe (SMA I), intermediate (SMA II), and mild (SMA III) patients, alongside age-match... Read More about The Proteome Signatures of Fibroblasts from Patients with Severe, Intermediate and Mild Spinal Muscular Atrophy Show Limited Overlap.

Typical median effective radiation doses using an anthropomorphic bone fracture phantom for initial radiographic skeletal surveys in the investigation of suspected physical abuse. (2022)
Journal Article
Doyle, E., Dimmock, M., Lee, K., Thomas, P., & Bassed, R. (2022). Typical median effective radiation doses using an anthropomorphic bone fracture phantom for initial radiographic skeletal surveys in the investigation of suspected physical abuse. Pediatric Radiology, https://doi.org/10.1007/s00247-022-05456-x

BACKGROUND: A series of 31 radiographs is recommended by the Royal College of Radiologists (RCR) when investigating suspected physical abuse (SPA). OBJECTIVE: To determine the radiation dose delivered for skeletal surveys performed for SPA in Victori... Read More about Typical median effective radiation doses using an anthropomorphic bone fracture phantom for initial radiographic skeletal surveys in the investigation of suspected physical abuse..

Human ankle joint movements during walking are probably not determined by talar morphology. (2022)
Journal Article
Wolf, P., Moor, R., Lundberg, A., Nester, C., Arndt, A., & Graf, E. (2022). Human ankle joint movements during walking are probably not determined by talar morphology. Scientific Reports, 12, Article 13856. https://doi.org/10.1038/s41598-022-17984-5

Knowledge about the orientation of a representative ankle joint axis is limited to studies of tarsal morphology and of quasistatic movements. The aim of our study was therefore to determine the development of the axis orientation during walking. Intr... Read More about Human ankle joint movements during walking are probably not determined by talar morphology..

Prevalence of and factors associated with osteoarthritis and pain in retired Olympians compared with the general population: part 2 – the spine and upper limb (2022)
Journal Article
Palmer, D., Cooper, D., Whittaker, J., Batt, M., Emery, C., Engebretsen, L., …Budget, R. (2022). Prevalence of and factors associated with osteoarthritis and pain in retired Olympians compared with the general population: part 2 – the spine and upper limb. British Journal of Sports Medicine, https://doi.org/10.1136/bjsports-2021-104978

<jats:sec><jats:title>Objectives</jats:title><jats:p>(1) To determine the prevalence of spine and upper limb osteoarthritis (OA) and pain in retired Olympians; (2) identify risk factors associated with their occurrence and (3) compare with a sample o... Read More about Prevalence of and factors associated with osteoarthritis and pain in retired Olympians compared with the general population: part 2 – the spine and upper limb.

Clot-Targeted Magnetic Hyperthermia Permeabilizes Blood Clots to Make Them More Susceptible to Thrombolysis (2022)
Journal Article
Cabrera, D., Sharifabad, M. E., Ranjbar, J. A., Telling, N. D., & Harper, A. G. (2022). Clot-Targeted Magnetic Hyperthermia Permeabilizes Blood Clots to Make Them More Susceptible to Thrombolysis. Journal of Thrombosis and Haemostasis, 20(11), https://doi.org/10.1111/jth.15846

BACKGROUND: Thrombolysis is a frontline treatment for stroke, which involves the application of tissue plasminogen activator (tPA) to trigger endogenous clot-degradation pathways.However, it is only effective within 4.5 hours of symptom onset due to... Read More about Clot-Targeted Magnetic Hyperthermia Permeabilizes Blood Clots to Make Them More Susceptible to Thrombolysis.

Routine Pressure Wire Assessment Versus Conventional Angiography in the Management of Patients With Coronary Artery Disease: The RIPCORD 2 Trial (2022)
Journal Article
Stables, R. H., Mullen, L. J., Elguindy, M., Nicholas, Z., Aboul-Enien, Y. H., Kemp, I., …Curzen, N. (2022). Routine Pressure Wire Assessment Versus Conventional Angiography in the Management of Patients With Coronary Artery Disease: The RIPCORD 2 Trial. Circulation, 146(9), 687-698. https://doi.org/10.1161/CIRCULATIONAHA.121.057793

Background: Measurement of fractional flow reserve (FFR) has an established role in guiding percutaneous coronary intervention. We tested the hypothesis that, at the stage of diagnostic invasive coronary angiography, systematic FFR-guided assessment... Read More about Routine Pressure Wire Assessment Versus Conventional Angiography in the Management of Patients With Coronary Artery Disease: The RIPCORD 2 Trial.

Prevalence of and factors associated with osteoarthritis and pain in retired Olympians, with comparison to the general population: part 1 – the lower limb (2022)
Journal Article
Shroff, M., Soligard, T., Batt, M., Steffen, K., Budgett, R., Palmer, D., …Schamasch, P. (2022). Prevalence of and factors associated with osteoarthritis and pain in retired Olympians, with comparison to the general population: part 1 – the lower limb. British Journal of Sports Medicine, https://doi.org/10.1136/bjsports-2021-104762

Association Between Gout Flare and Subsequent Cardiovascular Events Among Patients with Gout (2022)
Journal Article
Mamas. (2022). Association Between Gout Flare and Subsequent Cardiovascular Events Among Patients with Gout. Journal of the American Medical Association, https://doi.org/10.1001/jama.2022.11390

Importance Gout is associated with cardiovascular diseases. The temporal association between gout flares and cardiovascular events has not been investigated. Objective To investigate whether there is a transient increase in risk of cardiovascular eve... Read More about Association Between Gout Flare and Subsequent Cardiovascular Events Among Patients with Gout.

Cardiovascular Health Care Implications of the COVID-19 pandemic. (2022)
Journal Article
Mamas. (2022). Cardiovascular Health Care Implications of the COVID-19 pandemic. Cardiology Clinics, 389 - 396. https://doi.org/10.1016/j.ccl.2022.03.010

The coronavirus disease 2019 (COVID-19) pandemic has challenged the capacity of health care systems around the world, including substantial disruptions to cardiovascular care across key areas of health care delivery. In this narrative review, we exam... Read More about Cardiovascular Health Care Implications of the COVID-19 pandemic..

Understanding current UK practice for the incidental identification of vertebral fragility fractures from CT scans: an expert elicitation study (2022)
Journal Article
Luetchens, S., Cootes, T., Payne, K., Dalal, G., Bromiley, P., & Kariki, E. (2022). Understanding current UK practice for the incidental identification of vertebral fragility fractures from CT scans: an expert elicitation study. Aging clinical and experimental research, 1909 - 1918. https://doi.org/10.1007/s40520-022-02124-w

Background There is an emerging interest in using automated approaches to enable the incidental identifcation of vertebral
fragility fractures (VFFs) on existing medical images visualising the spine.
Aim To quantify values, and the degree of uncer... Read More about Understanding current UK practice for the incidental identification of vertebral fragility fractures from CT scans: an expert elicitation study.

Health Care Professional's Knowledge of Pregnancy Complications and Women's Cardiovascular Health: An International Study Utilizing Social Media (2022)
Journal Article
Wu, P., Mamas, M. A., & Gulati, M. (2022). Health Care Professional's Knowledge of Pregnancy Complications and Women's Cardiovascular Health: An International Study Utilizing Social Media. Journal of Women's Health, https://doi.org/10.1089/jwh.2021.0298

Background
Despite guidelines recommending the evaluation of adverse pregnancy outcomes (APOs) as a part of the atherosclerotic cardiovascular disease (ASCVD) risk assessment in women, there is limited awareness of this issue in healthcare professio... Read More about Health Care Professional's Knowledge of Pregnancy Complications and Women's Cardiovascular Health: An International Study Utilizing Social Media.

Effectiveness of a telehealth physiotherapist-delivered intensive dietary weight loss program combined with exercise in people with knee osteoarthritis and overweight or obesity: study protocol for the POWER randomized controlled trial. (2022)
Journal Article
Holden. (2022). Effectiveness of a telehealth physiotherapist-delivered intensive dietary weight loss program combined with exercise in people with knee osteoarthritis and overweight or obesity: study protocol for the POWER randomized controlled trial. BMC Musculoskeletal Disorders, 733 - ?. https://doi.org/10.1186/s12891-022-05685-z

BACKGROUND: Obesity is associated with knee osteoarthritis (OA). Weight loss, alongside exercise, is a recommended treatment for individuals with knee OA and overweight/obesity. However, many patients cannot access weight loss specialists such as die... Read More about Effectiveness of a telehealth physiotherapist-delivered intensive dietary weight loss program combined with exercise in people with knee osteoarthritis and overweight or obesity: study protocol for the POWER randomized controlled trial..

From detection to preparing for the end‐of‐life: A qualitative exploration of the South Asian family carers' experiences of the journey with dementia (2022)
Journal Article
Tarafdar, S., Kingstone, T., Campbell, P., Chew-Graham, C., & Hossain, M. (2022). From detection to preparing for the end‐of‐life: A qualitative exploration of the South Asian family carers' experiences of the journey with dementia. Health and Social Care in the Community, https://doi.org/10.1111/hsc.13930

People of South Asian (SA) origin have a higher prevalence of dementia compared with the United Kingdom (UK) population as a whole. Little is known about how family carers of SA origin perceive dementia, manage access to dementia services, and how pl... Read More about From detection to preparing for the end‐of‐life: A qualitative exploration of the South Asian family carers' experiences of the journey with dementia.

Dysregulation of Tweak and Fn14 in skeletal muscle of spinal muscular atrophy mice (2022)
Journal Article
Bowerman, Meijboom, K. E., Sutton, E. R., McCallion, E., McFall, E., Anthony, D., …Bowerman, M. (2022). Dysregulation of Tweak and Fn14 in skeletal muscle of spinal muscular atrophy mice. Skeletal Muscle, 12(1), 1-25. https://doi.org/10.1186/s13395-022-00301-z

Background: Spinal muscular atrophy (SMA) is a childhood neuromuscular disorder caused by depletion of the survival motor neuron (SMN) protein. SMA is characterized by the selective death of spinal cord motor neurons, leading to progressive muscle wa... Read More about Dysregulation of Tweak and Fn14 in skeletal muscle of spinal muscular atrophy mice.

Research priorities to reduce the impact of Musculoskeletal Disorders: a priority setting exercise using the CHRNI method (2022)
Journal Article
Paskins, Z., Farmer, C. E., Manning, F., Andersson, D. A., Barlow, T., Bishop, F. L., …Watt, F. E. (2022). Research priorities to reduce the impact of Musculoskeletal Disorders: a priority setting exercise using the CHRNI method. The Lancet Rheumatology, 4(9), E635-E645. https://doi.org/10.1016/S2665-9913%2822%2900136-9

Involving research users in setting priorities for research is essential to ensure research outcomes are patient-centred and to maximise research value and impact. The Musculoskeletal (MSK) Disorders Research Advisory Group Versus Arthritis led a res... Read More about Research priorities to reduce the impact of Musculoskeletal Disorders: a priority setting exercise using the CHRNI method.

Exploring the physical, psychological and social well-being of people with rheumatoid arthritis during the coronavirus pandemic: a single-centre, longitudinal, qualitative interview study in the UK (2022)
Journal Article
Brooks, M., Hassell, A., Ryan, S., Campbell, P., Paskins, Z., Hider, S., …Manning, F. (2022). Exploring the physical, psychological and social well-being of people with rheumatoid arthritis during the coronavirus pandemic: a single-centre, longitudinal, qualitative interview study in the UK. BMJ Open, 12, Article e056555

Objective Rheumatoid arthritis (RA) is an autoimmune, inflammatory, systemic condition that requires specific drug treatment to suppress disease activity and prevent joint deformity. To manage the ongoing symptoms of joint pain and fatigue patients a... Read More about Exploring the physical, psychological and social well-being of people with rheumatoid arthritis during the coronavirus pandemic: a single-centre, longitudinal, qualitative interview study in the UK.