Skip to main content

Research Repository

Advanced Search

Mesenchymal Stem Cell-Derived Extracellular Vesicles Reduce Disease Severity and Immune Responses in Inflammatory Arthritis (2020)
Other
Kay, A., Roach, P., Treadwell, K., Morgan, R., Lodge, R., Hyland, M., …Forsyth, N. R. (2020). Mesenchymal Stem Cell-Derived Extracellular Vesicles Reduce Disease Severity and Immune Responses in Inflammatory Arthritis

Abstract Background Novel biological therapies have revolutionised the management of Rheumatoid Arthritis (RA) but no cure currently exists. Mesenchymal stem cells (MSCs) immunomodulate inflammatory responses through paracrine signalling via growth f... Read More about Mesenchymal Stem Cell-Derived Extracellular Vesicles Reduce Disease Severity and Immune Responses in Inflammatory Arthritis.

Black hole inconsistencies? (2020)
Working Paper
Austin, J. Black hole inconsistencies?

For large enough astrophysical objects, internal pressures are insufficient to prevent gravitational collapse to sizes smaller than a critical radius where the magnitude of escape velocity is equal to the speed of light. In coordinates natural for di... Read More about Black hole inconsistencies?.

Glycosaminoglycans induce conformational change in the SARS-CoV-2 Spike S1 Receptor Binding Domain (2020)
Journal Article
Mycroft-West, C. J., Su, D., Li, Y., Guimond, S. E., Rudd, T. R., Elli, S., …Skidmore, M. A. Glycosaminoglycans induce conformational change in the SARS-CoV-2 Spike S1 Receptor Binding Domain. bioRxiv, https://doi.org/10.1101/2020.04.29.068767

The glycosaminoglycan (GAG) class of polysaccharides are utilised by a plethora of microbial pathogens as receptors for adherence and invasion. The GAG heparin prevents infection by a range of viruses when added exogenously, including the S-associate... Read More about Glycosaminoglycans induce conformational change in the SARS-CoV-2 Spike S1 Receptor Binding Domain.

SARS-CoV-2 Spike S1 Receptor Binding Domain undergoes Conformational Change upon Interaction with Low Molecular Weight Heparins (2020)
Journal Article
Mycroft-West, C. J., Su, D., Li, Y., Guimond, S. E., Rudd, T. R., Elli, S., …Skidmore, M. A. SARS-CoV-2 Spike S1 Receptor Binding Domain undergoes Conformational Change upon Interaction with Low Molecular Weight Heparins. arXiv, https://doi.org/10.1101/2020.04.29.068486

The dependence of the host on the interaction of hundreds of extracellular proteins with the cell surface glycosaminoglycan heparan sulphate (HS) for the regulation of homeostasis is exploited by many microbial pathogens as a means of adherence and i... Read More about SARS-CoV-2 Spike S1 Receptor Binding Domain undergoes Conformational Change upon Interaction with Low Molecular Weight Heparins.

The Right to Be Forgotten as a Fundamental Right in the UK After Brexit (2020)
Journal Article
Aidinlis. (2020). The Right to Be Forgotten as a Fundamental Right in the UK After Brexit. SSRN,

Will Brexit diminish digital rights protection in the UK or are domestic institutions better-placed to deliver such protection unencumbered by the oversight of EU institutions? This article scrutinises the validity of conflicting arguments about the... Read More about The Right to Be Forgotten as a Fundamental Right in the UK After Brexit.

A comparative analysis for SARS-CoV-2 (2020)
Journal Article
Misirli, G. A comparative analysis for SARS-CoV-2. Manuscript submitted for publication

COVID-19 has affected the world tremendously. It is critical that biological experiments and clinical designs are informed by computational approaches for time- and cost-effective solutions. Comparative analyses particularly can play a key role to re... Read More about A comparative analysis for SARS-CoV-2.

Improved CRISPR-based suppression gene drives mitigate resistance and impose a large reproductive load on laboratory-contained mosquito populations (2020)
Working Paper
Hammond, A. M., Kyrou, K., Gribble, M., Karlsson, X., Morianou, I., Galizi, R., …Nolan, T. Improved CRISPR-based suppression gene drives mitigate resistance and impose a large reproductive load on laboratory-contained mosquito populations

Abstract CRISPR-based genes drives bias their own inheritance and can be used to modify entire populations of insect vectors of disease as a novel form of sustainable disease control. Gene drives designed to interfere with female fertility can suppre... Read More about Improved CRISPR-based suppression gene drives mitigate resistance and impose a large reproductive load on laboratory-contained mosquito populations.

Contagion Testing in Embryonic Markets Under Alternative Stressful US Market Scenarios (2019)
Journal Article
Mahadeo, S. M., Heinlein, R., & Legrenzi, G. D. (2019). Contagion Testing in Embryonic Markets Under Alternative Stressful US Market Scenarios. SSRN, https://doi.org/10.2139/ssrn.3523533

We consolidate alternative ways for identifying stable and stressful scenarios in the S&P 500 market to construct contagion tests for recipient markets vulnerable to disturbances from this source market. The S&P 500 is decomposed into discrete condit... Read More about Contagion Testing in Embryonic Markets Under Alternative Stressful US Market Scenarios.

Genetic structure at national and regional scale in a long-distance dispersing pest organism, the bird cherry–oat aphid Rhopalosiphum padi (2019)
Journal Article
Morales-Hojas, R., Gonzalez-Uriarte, A., Alvira Iraizoz, F., Jenkins, T., Alderson, L., Kruger, T., …Bell, J. R. (2019). Genetic structure at national and regional scale in a long-distance dispersing pest organism, the bird cherry–oat aphid Rhopalosiphum padi. bioRxiv, https://doi.org/10.1101/829986

Genetic diversity is determinant for pest species’ success and vector competence. Understanding the ecological and evolutionary processes that determine the genetic diversity is fundamental to help identify the spatial scale at which pest populations... Read More about Genetic structure at national and regional scale in a long-distance dispersing pest organism, the bird cherry–oat aphid Rhopalosiphum padi.

Definition of Internet of Things (IoT) Cyber Risk – Discussion on a Transformation Roadmap for Standardisation of Regulations, Risk Maturity, Strategy Design and Impact Assessment (2019)
Journal Article
Radanliev, P., De Roure, D., R.C. Nurse, J., Burnap, P., Anthi, E., Ani, U., …Mantilla Montalvo, R. Definition of Internet of Things (IoT) Cyber Risk – Discussion on a Transformation Roadmap for Standardisation of Regulations, Risk Maturity, Strategy Design and Impact Assessment. Preprints, https://doi.org/10.20944/preprints201903.0080.v1

Offensive but not so offensive Fostering Ethical and Socially Responsible Marketing in Undergraduate Marketing Students (2018)
Journal Article
Mogaji, E. (2018). Offensive but not so offensive Fostering Ethical and Socially Responsible Marketing in Undergraduate Marketing Students. Advance, https://doi.org/10.31124/advance.7203266

Advertising that pushes the boundaries can sometimes be negatively received, some of these advertisements were reported to the regulator of advertising in the UK while Companies has had to apologise for their advertisements. The systemic diversity pr... Read More about Offensive but not so offensive Fostering Ethical and Socially Responsible Marketing in Undergraduate Marketing Students.

WASP-86b and WASP-102b: super-dense versus bloated planets (2016)
Journal Article
Smalley, Hellier, & Maxted. (2016). WASP-86b and WASP-102b: super-dense versus bloated planets. arXiv,

We report the discovery of two transiting planetary systems: a super dense, sub-Jupiter mass planet WASP-86b (Mpl = 0.82 ± 0.06 MJ; Rpl = 0.63 ± 0.01 RJ), and a bloated, Saturn-like planet WASP-102b (Mpl = 0.62 ± 0.04 MJ; Rpl = 1.27 ± 0.03 RJ). They... Read More about WASP-86b and WASP-102b: super-dense versus bloated planets.

On the Prediction of Emerging Market Sovereign Credit Spreads (2015)
Journal Article
Audzeyeva, A., & Fuertes, A. (2015). On the Prediction of Emerging Market Sovereign Credit Spreads. https://doi.org/10.2139/ssrn.2649216

This paper examines the quarter-ahead out-of-sample predictability of Brazil, Mexico, the Philippines and Turkey credit spreads before and after the Lehman Brothers' default. A model based on the country-specific credit spread curve factors predicts... Read More about On the Prediction of Emerging Market Sovereign Credit Spreads.

Emerging Market Sovereign Credit Spreads: In-Sample and Out-of-Sample Predictability (2015)
Journal Article
Audzeyeva, A., & Fuertes, A. (2015). Emerging Market Sovereign Credit Spreads: In-Sample and Out-of-Sample Predictability. https://doi.org/10.2139/ssrn.2649216

This paper investigates the quarter-ahead predictability of Brazil, Mexico, Philippines and Turkey credit spreads for short and long maturity bonds during two separate periods preceding and following the Lehman Brothers' default. A model based on the... Read More about Emerging Market Sovereign Credit Spreads: In-Sample and Out-of-Sample Predictability.

Six newly-discovered hot Jupiters transiting F/G stars: WASP-87b, WASP-108b, WASP-109b, WASP-110b, WASP-111b & WASP-112b (2014)
Journal Article
Anderson, D., Brown, D., Collier Cameron, A., Delrez, L., Fumel, A., Gillon, M., …West, R. (2014). Six newly-discovered hot Jupiters transiting F/G stars: WASP-87b, WASP-108b, WASP-109b, WASP-110b, WASP-111b & WASP-112b. arXiv,

We present the discoveries of six transiting hot Jupiters: WASP-87b, WASP-108b, WASP-109b, WASP-110b, WASP-111b and WASP-112b. The planets have masses of 0.51--2.2 MJup and radii of 1.19--1.44 RJup and are in orbits of 1.68--3.78 d around stars with... Read More about Six newly-discovered hot Jupiters transiting F/G stars: WASP-87b, WASP-108b, WASP-109b, WASP-110b, WASP-111b & WASP-112b.

Difficulties in Probing Nuclear Physics: A Study of Ti and Ni (2008)
Presentation / Conference
Hungerford, A., Fryer, C. L., Timmes, F. X., Young, P., Bennett, M., Diehl, S., …Rockefeller, G. (2008, July). Difficulties in Probing Nuclear Physics: A Study of Ti and Ni. Paper presented at 10th Symposium on Nuclei in the Cosmos, Mackinac Island, Michigan, USA

The nucleosynthetic yield from a supernova explosion depends upon a variety of effects: progenitor evolution, explosion process, details of the nuclear network, and nuclear rates. Especially in studies of integrated stellar yields, simplifications re... Read More about Difficulties in Probing Nuclear Physics: A Study of Ti and Ni.