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Welcome to Keele Repository

The Keele Repository is intended to be an Open Access showcase for the published research output of the university. Whenever possible, refereed documents accepted for publication, or finished artistic compositions presented in public, will be made available here in full digital format, and hyperlinks to standard published versions will be provided.



Latest Additions

Police culture in a diverse society: provincial police force in transition? (2007)
Thesis
Loftus, B. (2007). Police culture in a diverse society: provincial police force in transition?. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/849118

This thesis is an ethnographic investigation into the occupational value systems and practices of contemporary police officers in a provincial English police force. Situated in the local context of Staffordshire Police, the thesis revisits the notion... Read More about Police culture in a diverse society: provincial police force in transition?.

Effect of application of gamma amino butyric acid at the medial preoptic area on sleep-wakefulness (1995)
Journal Article
Chari, D. M., Ramesh, V., John, J., & Mohan Kumar, V. (1995). Effect of application of gamma amino butyric acid at the medial preoptic area on sleep-wakefulness. Indian Journal of Physiology and Pharmacology, 39(3),

Abstract: Intracerebral microinjections of gamma amino butyric acid were Given bilaterally at the medial preoptic area (mPOA) to determine the possible role of this neurotran mitter in the genesis and regulation of leep-wakefulness. GABA (50 Ilg/0.2... Read More about Effect of application of gamma amino butyric acid at the medial preoptic area on sleep-wakefulness.

Depletion of endogenous oligodendrocyte progenitors rather than increased availability of survival factors is a likely explanation for enhanced survival of transplanted oligodendrocyte progenitors in X‐irradiated compared to normal CNS (2001)
Journal Article
Hinks, G. L., Chari, D. M., T. O'Leary, M., Zhao, C., Keirstead, H. S., Blakemore, W. F., & Franklin, R. J. M. (2001). Depletion of endogenous oligodendrocyte progenitors rather than increased availability of survival factors is a likely explanation for enhanced survival of transplanted oligodendrocyte progenitors in X‐irradiated compared to normal CNS. Neuropathology and Applied Neurobiology, 27(1), 59-67. https://doi.org/10.1046/j.0305-1846.2001.00303.x

Oligodendrocyte progenitors (OPs) survive and migrate following transplantation into adult rat central nervous system (CNS) exposed to high levels of X-irradiation but fail to do so if they are transplanted into normal adult rat CNS. In the context o... Read More about Depletion of endogenous oligodendrocyte progenitors rather than increased availability of survival factors is a likely explanation for enhanced survival of transplanted oligodendrocyte progenitors in X‐irradiated compared to normal CNS.

Efficient recolonisation of progenitor‐depleted areas of the CNS by adult oligodendrocyte progenitor cells (2002)
Journal Article
Chari, D. M., & Blakemore, W. F. (2002). Efficient recolonisation of progenitor‐depleted areas of the CNS by adult oligodendrocyte progenitor cells. Glia, 37(4), 307-313. https://doi.org/10.1002/glia.10038

A widely quoted hypothesis for the failure of remyelination in multiple sclerosis (MS) is the exhaustion of the oligodendrocyte progenitor cell (OPC) pool that is strongly implicated as the source of remyelinating oligodendrocytes in demyelinating le... Read More about Efficient recolonisation of progenitor‐depleted areas of the CNS by adult oligodendrocyte progenitor cells.

Modelling large areas of demyelination in the rat reveals the potential and possible limitations of transplanted glial cells for remyelination in the CNS (2002)
Journal Article
Blakemore, W., Chari, D., Gilson, J., & Crang, A. (2002). Modelling large areas of demyelination in the rat reveals the potential and possible limitations of transplanted glial cells for remyelination in the CNS. Glia, 38(2), 155-168. https://doi.org/10.1002/glia.10067

Transplantation of myelin-forming glial cells may provide a means of achieving remyelination in situations in which endogenous remyelination fails. For this type of cell therapy to be successful, cells will have to migrate long distances in normal ti... Read More about Modelling large areas of demyelination in the rat reveals the potential and possible limitations of transplanted glial cells for remyelination in the CNS.