Development and initial evaluation of a clinical prediction model for risk of treatment resistance in first-episode psychosis: Schizophrenia Prediction of Resistance to Treatment (SPIRIT)

Farooq, Saeed; Hattle, Miriam; Kingstone, Tom; Ajnakina, Olesya; Dazzan, Paola; Demjaha, Arsime; Murray, Robin M.; Di Forti, Marta; Jones, Peter B.; Doody, Gillian A.; Shiers, David; Andrews, Gabrielle; Milner, Abbie; Nettis, Maria Antonietta; Lawrence, Andrew J.; van der Windt, Danielle A.; Riley, Richard D.

doi:10.1192/bjp.2024.101

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Odontothrips loti (Haliday) (Thysanoptera: Thripidae) is one of the most serious pests on alfalfa, causing direct damage by feeding and indirect damage by transmitting plant viruses. This damage causes significant loss in alfalfa production. Semioche... Read More about Identification of Aggregation Pheromone as an Attractant for Odontothrips loti, A Serious Thrips Pest on Alfalfa.

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Purpose Androgen deprivation therapy (ADT) is a mainstay of treatment for prostate cancer (PCa) and is associated with increased risks of osteoporosis and fragility fractures. Despite international guidelines to mitigate fracture risk, osteoporosis... Read More about Implementation of fracture risk assessment in men with prostate cancer requiring long-term androgen deprivation therapy: a systematic scoping review using the i-PARIHS implementation framework.

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Development and initial evaluation of a clinical prediction model for risk of treatment resistance in first-episode psychosis: Schizophrenia Prediction of Resistance to Treatment (SPIRIT) (2024)
Journal Article
Farooq, S., Hattle, M., Kingstone, T., Ajnakina, O., Dazzan, P., Demjaha, A., …Riley, R. D. (in press). Development and initial evaluation of a clinical prediction model for risk of treatment resistance in first-episode psychosis: Schizophrenia Prediction of Resistance to Treatment (SPIRIT). British Journal of Psychiatry, 1-10. https://doi.org/10.1192/bjp.2024.101

Background A clinical tool to estimate the risk of treatment-resistant schizophrenia (TRS) in people with first-episode psychosis (FEP) would inform early detection of TRS and overcome the delay of up to 5 years in starting TRS medication. Aims... Read More about Development and initial evaluation of a clinical prediction model for risk of treatment resistance in first-episode psychosis: Schizophrenia Prediction of Resistance to Treatment (SPIRIT).