Multicomponent Synthesis of the SARS-CoV-2 Main Protease Inhibitor Nirmatrelvir
(2023)
Journal Article
Preschel, H. D., Otte, R. T., Zhuo, Y., Ruscoe, R. E., Burke, A. J., Kellerhals, R., Horst, B., Hennig, S., Janssen, E., Green, A. P., Turner, N. J., & Ruijter, E. (2023). Multicomponent Synthesis of the SARS-CoV-2 Main Protease Inhibitor Nirmatrelvir. Journal of Organic Chemistry, 88(17), 12565-12571. https://doi.org/10.1021/acs.joc.3c01274
In the wake of the Covid-19 pandemic, it has become clear that global access to efficacious antiviral drugs will be critical to combat future outbreaks of SARS-CoV-2 or related viruses. The orally available SARS-CoV-2 main protease inhibitor nirmatre... Read More about Multicomponent Synthesis of the SARS-CoV-2 Main Protease Inhibitor Nirmatrelvir.