Outputs (16)

Should all people starting urate-lowering therapy for gout receive anti-inflammatory prophylaxis? (2024)
Journal Article
Roddy, E., Prior, J. A., & Mallen, C. D. (2024). Should all people starting urate-lowering therapy for gout receive anti-inflammatory prophylaxis?. Exploration of Musculoskeletal Diseases, 2, 521-528. https://doi.org/10.37349/emd.2024.00076

Co-prescription of anti-inflammatory prophylaxis with colchicine, non-steroidal anti-inflammatory drugs (NSAIDs), or corticosteroids when initiating urate-lowering therapy (ULT) for gout is recommended in clinical guidelines to prevent ULT-induced fl... Read More about Should all people starting urate-lowering therapy for gout receive anti-inflammatory prophylaxis?.

Trends in Management and Consultations for Gout: A Study of 18 Million Adults Using the OpenSAFELY Platform (2024)
Presentation / Conference Contribution
Russell, M., Massey, J., Roddy, E., MacKenna, B., Bacon, S., Goldacre, B., Andrews, C., Hickman, G., Mehrkar, A., Mahto, A., Rutherford, A., Patel, S., Adas, M., Alveyn, E., Nagra, . D., Bechman, K., Ledingham, J., Hudson, J., Norton, S., Cope, A., & Galloway, J. (2024, November). Trends in Management and Consultations for Gout: A Study of 18 Million Adults Using the OpenSAFELY Platform. Poster presented at Abstract Supplement ACR Convergence 2024, Washington DC

Background/Purpose: Data from before the COVID-19 pandemic had shown persistently poor care for people with gout in many countries worldwide. Whether this was further exacerbated by the pandemic is not fully understood. Our objective was to investiga... Read More about Trends in Management and Consultations for Gout: A Study of 18 Million Adults Using the OpenSAFELY Platform.

Publisher Correction: A genome-wide association analysis reveals new pathogenic pathways in gout. (2024)
Journal Article
Major, T. J., Takei, R., Matsuo, H., Leask, M. P., Sumpter, N. A., Topless, R. K., Shirai, Y., Wang, W., Cadzow, M. J., Phipps-Green, A. J., Li, Z., Ji, A., Merriman, M. E., Morice, E., Kelley, E. E., Wei, W.-H., McCormick, S. P. A., Bixley, M. J., Reynolds, R. J., Saag, K. G., …Merriman, T. R. (2024). Publisher Correction: A genome-wide association analysis reveals new pathogenic pathways in gout. Nature Genetics, 56(11), Article 2577. https://doi.org/10.1038/s41588-024-02017-w

In the version of the article originally published, there were errors in the consortium lists at the end of the paper. Maureen Rischmueller, Hyon K. Choi, Masahiro Nakatochi, Jeff N. Miner, Daniel H. Solomon, Kathleen M. Giacomini and Deanna J. Brack... Read More about Publisher Correction: A genome-wide association analysis reveals new pathogenic pathways in gout..

A genome-wide association analysis reveals new pathogenic pathways in gout. (2024)
Journal Article
Major, T. J., Takei, R., Matsuo, H., Leask, M. P., Sumpter, N. A., Topless, R. K., Shirai, Y., Wang, W., Cadzow, M. J., Phipps-Green, A. J., Li, Z., Ji, A., Merriman, M. E., Morice, E., Kelley, E. E., Wei, W.-H., McCormick, S. P. A., Bixley, M. J., Reynolds, R. J., Saag, K. G., …Merriman, T. R. (in press). A genome-wide association analysis reveals new pathogenic pathways in gout. Nature Genetics, https://doi.org/10.1038/s41588-024-01921-5

Gout is a chronic disease that is caused by an innate immune response to deposited monosodium urate crystals in the setting of hyperuricemia. Here, we provide insights into the molecular mechanism of the poorly understood inflammatory component of go... Read More about A genome-wide association analysis reveals new pathogenic pathways in gout..

Pain Reduction With Oral Methotrexate in Knee Osteoarthritis (2024)
Journal Article
Kingsbury, S. R., Tharmanathan, P., Keding, A., Watt, F. E., Scott, D. L., Roddy, E., Birrell, F., Arden, N. K., Bowes, M., Arundel, C., Watson, M., Ronaldson, S. J., Hewitt, C., Doherty, M., Moots, R. J., O’Neill, T. W., Green, M., Patel, G., Garrood, T., Edwards, C. J., …Conaghan, P. G. (in press). Pain Reduction With Oral Methotrexate in Knee Osteoarthritis. Annals of Internal Medicine, 177(9), https://doi.org/10.7326/m24-0303

AB0105 ‘..THERE’S TOO MUCH TO PUT IN A LEAFLET’: A QUALITATIVE EXPLORATION OF STAKEHOLDER VIEWS OF LIFESTYLE INTERVENTIONS FOR GOUT (2024)
Presentation / Conference Contribution
Watson, L., Cornwall, N., Jinks, C., Bradbury, K., Goff, L., Little, P., Mallen, C., & Roddy, E. (2024, June). AB0105 ‘..THERE’S TOO MUCH TO PUT IN A LEAFLET’: A QUALITATIVE EXPLORATION OF STAKEHOLDER VIEWS OF LIFESTYLE INTERVENTIONS FOR GOUT. Paper presented at EULAR 2024 European Congress of Rheumatology, 12-15 June. Vienna, Austria, Vienna

Background: Lifestyle has been associated with gout for centuries and dietary triggers of flares remain of great interest to people with gout. However, there is a lack of robust clinical trial evidence about the eff... Read More about AB0105 ‘..THERE’S TOO MUCH TO PUT IN A LEAFLET’: A QUALITATIVE EXPLORATION OF STAKEHOLDER VIEWS OF LIFESTYLE INTERVENTIONS FOR GOUT.

P082 Nephrolithiasis associated with uricosuric therapies for the treatment of gout: a systematic review (2024)
Presentation / Conference
Dahanayake, C., Bajpai, R., Jordan, K. M., Lambie, M., & Roddy, E. (2024, April). P082 Nephrolithiasis associated with uricosuric therapies for the treatment of gout: a systematic review. Poster presented at British Society for Rheumatology Annual Conference 2024

Background/Aims
Uric acid nephrolithiasis is a recognised side-effect of uricosuric therapies and a contraindication to their use. The objective of this systematic review was to assess the incidence and risk of nephrolithiasis in people with gout re... Read More about P082 Nephrolithiasis associated with uricosuric therapies for the treatment of gout: a systematic review.

P085 Implementing treat-to-target urate-lowering therapy during hospitalisations for gout flares: a prospective cohort study (2024)
Presentation / Conference Contribution
Russell, M. D., Ameyaw-Kyeremeh, L., Dell'Accio, F., Lapham, H., Head, N., Stovin, C., Patel, V., Clarke, B., Nagra, D., Alveyn, E., Adas, M. A., Bechman, K., de la Puente, M. A., Ellis, B., Byrne, C., Patel, R., Rutherford, A. I., Cantle, F., Norton, S., Roddy, E., …Galloway, J. B. (2024, April). P085 Implementing treat-to-target urate-lowering therapy during hospitalisations for gout flares: a prospective cohort study. Poster presented at British Society for Rheumatology Annual Conference 2024

Background/Aims Hospitalisations for gout flares have doubled in England during the last 15 years. Despite this, no studies have evaluated strategies designed to increase the uptake of urate-lowering therapy (ULT) in people hospitalised for gout flar... Read More about P085 Implementing treat-to-target urate-lowering therapy during hospitalisations for gout flares: a prospective cohort study.

P086 Trends in the Incidence and Management of Gout in England: A Nationwide Study using the OpenSAFELY Platform (2024)
Presentation / Conference Contribution
Russell, M. D., Massey, J., Roddy, E., MacKenna, B., Bacon, S., Goldacre, B., Andrews, C. D., Hickman, G., Mehrkar, A., Mahto, A., Rutherford, A. I., Patel, S., Adas, M. A., Alveyn, E., Nagra, D., Bechman, K., Ledingham, J. M., Hudson, J., Norton, S., Cope, A., & Galloway, J. (2024, April). P086 Trends in the Incidence and Management of Gout in England: A Nationwide Study using the OpenSAFELY Platform. Poster presented at British Society for Rheumatology Annual Conference 2024

Background/Aims Gout is the most common inflammatory arthritis worldwide, yet one of the worst managed. Few population-level studies have evaluated how the COVID-19 pandemic impacted on incidence, prevalence, management and hospitalisations for peopl... Read More about P086 Trends in the Incidence and Management of Gout in England: A Nationwide Study using the OpenSAFELY Platform.

Effectiveness of footwear and foot orthoses in reducing medial metatarsophalangeal joint pressure in women with hallux valgus (2024)
Journal Article
Roddy, E., Menz, H., Lim, P., Hurn, S., Mickle, K., Buldt, A., Cotchett, M., Wluka, A., Erbas, B., & Munteanu, S. (2024). Effectiveness of footwear and foot orthoses in reducing medial metatarsophalangeal joint pressure in women with hallux valgus. Gait and Posture, 111, 156-161. https://doi.org/10.1016/j.gaitpost.2024.04.021

Background
Hallux valgus is a common condition where the subluxation of the first metatarsophalangeal joint and lateral deviation of the hallux at the interphalangeal joint creates difficulty with footwear fit. Footwear and foot orthoses are commonl... Read More about Effectiveness of footwear and foot orthoses in reducing medial metatarsophalangeal joint pressure in women with hallux valgus.