Outputs (4)

Centre-level fluid management practices in the BISTRO trial and their lack of association with participant fluid status and blood pressure in non-anuric haemodialysis patients (2024)
Journal Article
Johal, N., Sharma, R., Belcher, J., Coyle, D., Lindley, E. J., Keane, D., Caskey, F. J., Dasgupta, I., Davenport, A., Farrington, K., Mitra, S., Ormandy, P., Wilkie, M., Macdonald, J., Solis-Trapala, I., Sim, J., & Davies, S. J. (2024). Centre-level fluid management practices in the BISTRO trial and their lack of association with participant fluid status and blood pressure in non-anuric haemodialysis patients. BMC Nephrology, 25(1), Article 398. https://doi.org/10.1186/s12882-024-03837-y

Introduction: Fluid assessment and management is a key aspect of good dialysis care and is affected by patient-level characteristics and potentially centre-level practices. In this secondary analysis of the BISTRO trial we wished to establish whether... Read More about Centre-level fluid management practices in the BISTRO trial and their lack of association with participant fluid status and blood pressure in non-anuric haemodialysis patients.

Impact of the Preservation of Residual Kidney Function on Hemodialysis Survival: Results from the BISTRO Trial (2024)
Journal Article
Belcher, J., Coyle, D., Lindley, E. J., Keane, D., Caskey, F. J., Dasgupta, I., Davenport, A., Farrington, K., Mitra, S., Ormandy, P., Wilkie, M., Macdonald, J., Hugo Macdonald, J., Solis-Trapala, I., Sim, J., & Davies, S. J. (2024). Impact of the Preservation of Residual Kidney Function on Hemodialysis Survival: Results from the BISTRO Trial. Kidney360, https://doi.org/10.34067/kid.0000000596

Preservation of residual kidney function (RKF) in dialysis patients has been associated with improved survival. RKF in the BISTRO trial was relatively well preserved and here we describe its association with survival during the trial and extended fol... Read More about Impact of the Preservation of Residual Kidney Function on Hemodialysis Survival: Results from the BISTRO Trial.

Cost-effectiveness of bioimpedance-guided fluid management in patients undergoing haemodialysis: the BISTRO RCT (2024)
Journal Article
Zanganeh, M., Belcher, J., Fotheringham, J., Coyle, D., Lindley, E. J., Keane, D. F., Caskey, F. J., Dasgupta, I., Davenport, A., Farrington, K., Mitra, S., Ormandy, P., Wilkie, M., Macdonald, J. H., Solis-Trapala, I., Sim, J., Davies, S. J., & Andronis, L. (2024). Cost-effectiveness of bioimpedance-guided fluid management in patients undergoing haemodialysis: the BISTRO RCT. Health Technology Assessment, 1-45. https://doi.org/10.3310/jypr4287

Background
The BioImpedance Spectroscopy to maintain Renal Output randomised controlled trial investigated the effect of bioimpedance spectroscopy added to a standardised fluid management protocol on the risk of anuria and preservation of residual k... Read More about Cost-effectiveness of bioimpedance-guided fluid management in patients undergoing haemodialysis: the BISTRO RCT.

What do RCTs tell us, and could they tell us more? Looking within and beyond the study sample (2024)
Book Chapter
Sim, J., Lancaster, G., & Lewis, M. (2024). What do RCTs tell us, and could they tell us more? Looking within and beyond the study sample. In A Medical Educator's Guide to Thinking Critically about Randomised Controlled Trials: Deconstructing the "Gold Standard" (109-144). Springer Nature [academic journals on nature.com]. https://doi.org/10.1007/978-3-031-25859-6_5

Randomised controlled trials (RCTs) are generally regarded as the gold-standard method to answer questions of treatment effectiveness. Carefully designed and rigorously implemented, they can provide unbiased estimates of average treatment effectivene... Read More about What do RCTs tell us, and could they tell us more? Looking within and beyond the study sample.