Outputs (10)

The Impact of Age and Sex on Fasting Plasma Glucose and Glycated Haemoglobin (HbA1c) in the Non-diabetes Population. (2024)
Journal Article
Stedman, M., Heald, A. H., Holland, D., Halsall, I., Green, L., Wu, P., Patel, K., Scargill, J., Gibson, M., Hanna, F. W. F., & Fryer, A. A. (in press). The Impact of Age and Sex on Fasting Plasma Glucose and Glycated Haemoglobin (HbA1c) in the Non-diabetes Population. Diabetes Therapy, https://doi.org/10.1007/s13300-024-01680-w

We previously reported sex differences in the distribution of glycated haemoglobin (HbA1c) for men/women aged < 50 years vs older individuals, with implications for delayed diabetes diagnosis. Here, we explored whether this pattern was also seen in m...

Using maternal glycosylated haemoglobin as well as glucose tolerance tests identified significantly more mothers with high birth weight in their offspring (2024)
Presentation / Conference Contribution
Wu, P., Stedman, M., Fryer, A., Green, L., Holland, D., Scargill, J., Pankaja, S., Christian, S., & Heald, A. Using maternal glycosylated haemoglobin as well as glucose tolerance tests identified significantly more mothers with high birth weight in their offspring. Presented at 60th EASD Annual Meeting of the European Association for the Study of Diabetes, Madrid, Spain

The link between age, sex, fasting plasma glucose and glycated haemoglobin (HbA 1c ) (2024)
Presentation / Conference Contribution
Stedman, M., Heald, A., Holland, D., Halsall, I., Green, L., Wu, P., Scargill, J., Hanna, F., Colclough, K., Gibson, M., & Fryer, A. The link between age, sex, fasting plasma glucose and glycated haemoglobin (HbA 1c ). Presented at 60th Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD), Madrid, Spain

The OBS UK Dashboard: an interactive tool for representative trial site selection to facilitate equality and diversity in maternity research (2024)
Journal Article
Elsmore, A., Rai, T., Pallmann, P., Townson, J., Kotecha, S., Black, M., Sanders, J., Collis, R., Collins, P., Karunakaran, B., Wu, P., Bell, S., & Parry-Smith, W. (in press). The OBS UK Dashboard: an interactive tool for representative trial site selection to facilitate equality and diversity in maternity research. Trials, 25(1), Article 629. https://doi.org/10.1186/s13063-024-08487-x

Background: Obstetric Bleeding Study UK (OBS UK) (award ID: 152057) is a National Institute for Health and Care Research (NIHR)-funded stepped wedge cluster randomised controlled trial of a complex intervention for postpartum haemorrhage. This was de... Read More about The OBS UK Dashboard: an interactive tool for representative trial site selection to facilitate equality and diversity in maternity research.

O24 ACUTE KIDNEY INJURY IN PREGNANCY AND CARDIO-RENAL OUTCOMES: A SYSTEMATIC REVIEW AND META-ANALYSIS (2024)
Presentation / Conference
Jeyaraman, D., Peiris, T. D. P., Alahmdi, H., Fish, R., Lambie, M., & Wu, P. (2024, September). O24 ACUTE KIDNEY INJURY IN PREGNANCY AND CARDIO-RENAL OUTCOMES: A SYSTEMATIC REVIEW AND META-ANALYSIS. Presented at 30th Congress of the International Society of Hypertension, Cartegena de Indias, Colombia

Background and Objective: Acute kidney injury (AKI) is a common problem in pregnancy but adverse cardio-renal outcomes following AKI in pregnancy has not been systematically evaluated. We aimed to quantify the risk of adverse cardio-renal outcomes of... Read More about O24 ACUTE KIDNEY INJURY IN PREGNANCY AND CARDIO-RENAL OUTCOMES: A SYSTEMATIC REVIEW AND META-ANALYSIS.

Could primary care records be used to identify women at risk of perinatal anxiety? A mixed-methods study (2024)
Presentation / Conference Contribution
Fisher, T., Archer, C., Bailey, J., Evans, J., Kessler, D. S., Kingstone, T., Petersen, I., Proctor, J., Shivji, N., Spruce, A., Silverwood, V., Smith, H., Turner, K., Wu, P., Yu, D., & Chew-Graham, C. (2024, March). Could primary care records be used to identify women at risk of perinatal anxiety? A mixed-methods study. Presented at BJGP Research & Publishing Conference, RCGP Headquarters in London, England, UK

Perinatal anxiety (PNA) occurs throughout the antenatal period or up to 1 year after childbirth, with a prevalence of 21%. To investigate if primary care records could be used to identify women at 'higher risk' of PNA. Mixed-methods approach using qu... Read More about Could primary care records be used to identify women at risk of perinatal anxiety? A mixed-methods study.

Syngeneic mesenchymal stem cells loaded with telomerase-dependent oncolytic adenoviruses enhance anti-metastatic efficacy. (2024)
Journal Article
Yang, M.-L., Hu, C.-Y., Lee, Y.-C., Chang, C.-C., Chen, Y.-C., Lee, P.-R., Su, B.-H., Chen, P.-C., Shiau, A.-L., Shieh, G.-S., Wu, C.-L., & Wu, P. (in press). Syngeneic mesenchymal stem cells loaded with telomerase-dependent oncolytic adenoviruses enhance anti-metastatic efficacy. Stem Cells Translational Medicine, Article szae039. https://doi.org/10.1093/stcltm/szae039

Oncolytic adenoviruses have emerged as a promising therapeutic approach for cancer therapy. However, systemic delivery of the viruses to metastatic tumors remains a major challenge. Mesenchymal stem cells (MSCs) possess tumor tropism property and can... Read More about Syngeneic mesenchymal stem cells loaded with telomerase-dependent oncolytic adenoviruses enhance anti-metastatic efficacy..

Effects of vitamin D in pregnancy on maternal and offspring health-related outcomes: An umbrella review of systematic review and meta-analyses (2024)
Journal Article
Chien, M.-C., Huang, C.-Y., Wang, J.-H., Shih, C.-L., & Wu, P. (in press). Effects of vitamin D in pregnancy on maternal and offspring health-related outcomes: An umbrella review of systematic review and meta-analyses. Nutrition and Diabetes, 14(1), Article 35. https://doi.org/10.1038/s41387-024-00296-0

Background
Vitamin D deficiency has been linked with several adverse maternal and fetal outcomes.

Objective
To summarize systematic reviews and meta-analyses evaluating the effects of vitamin D deficiency and of vitamin D supplementation in preg... Read More about Effects of vitamin D in pregnancy on maternal and offspring health-related outcomes: An umbrella review of systematic review and meta-analyses.

Pregnancy-Associated Cancer: A Systematic Review and Meta-Analysis (2024)
Journal Article
Walters, B., Midwinter, I., A. Chew-Graham, C., P. Jordan, K., Sharma, G., C. Chappell, L., J. Crosbie, E., Parwani, P., A. Mamas, M., & Wu, P. (2024). Pregnancy-Associated Cancer: A Systematic Review and Meta-Analysis. Mayo Clinic Proceedings, 8(2), 188-199. https://doi.org/10.1016/j.mayocpiqo.2024.02.002

This study aimed to systematically evaluate and quantify the risk of adverse maternal and neonatal outcomes in patients with pregnancy-associated cancer (PAC). This study was conducted from February 13, 2021, through July 24, 2023.... Read More about Pregnancy-Associated Cancer: A Systematic Review and Meta-Analysis.

Adverse pregnancy outcomes in pregnant women with chronic kidney disease: A systematic review and meta‐analysis (2024)
Journal Article
Jeyaraman, D., Walters, B., Bramham, K., Fish, R., Lambie, M., & Wu, P. (2024). Adverse pregnancy outcomes in pregnant women with chronic kidney disease: A systematic review and meta‐analysis. BJOG: An International Journal of Obstetrics and Gynaecology, https://doi.org/10.1111/1471-0528.17807

Background
Chronic kidney disease (CKD) is associated with an increased risk of adverse pregnancy outcomes, but the risk at different stages of CKD (defined by estimated glomerular filtration rate, eGFR) compared with women without CKD has not been... Read More about Adverse pregnancy outcomes in pregnant women with chronic kidney disease: A systematic review and meta‐analysis.