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Outputs (502)

Regularized parametric survival modeling to improve risk prediction models (2023)
Journal Article
Hoogland, J., Debray, T., Crowther, M., Riley, R., IntHout, J., Reitsma, J., & Zwinderman, A. (2024). Regularized parametric survival modeling to improve risk prediction models. Biometrical Journal, 66(1), Article 2200319

We propose to combine the benefits of flexible parametric survival modeling and regularization to improve risk prediction modeling in the context of time-to-event data. Thereto, we introduce ridge, lasso, elastic net, and group lasso penalties for bo... Read More about Regularized parametric survival modeling to improve risk prediction models.

Cerebral edema in intracerebral hemorrhage: pathogenesis, natural history, and potential treatments from translation to clinical trials (2023)
Journal Article
Krishnan, K., Campos, P. B., Nguyen, T. N., Tan, C. W., Chan, S. L., Appleton, J. P., Law, Z., Hollingworth, M., Kirkman, M. A., England, T. J., Roffe, C., Macleod, M. J., Dawson, J., Bayraktutan, U., Werring, D. J., Sprigg, N., & Bath, P. M. (in press). Cerebral edema in intracerebral hemorrhage: pathogenesis, natural history, and potential treatments from translation to clinical trials. Frontiers in Stroke, 2, 1256664. https://doi.org/10.3389/fstro.2023.1256664

Acute intracerebral hemorrhage is the most devastating stroke subtype and is associated with significant morbidity and mortality. Poor prognosis is associated with primary brain injury from the presenting hematoma, and despite advances in clinical tr... Read More about Cerebral edema in intracerebral hemorrhage: pathogenesis, natural history, and potential treatments from translation to clinical trials.

Prognosis of Patients With Neuropathic Low Back-Related Leg Pain: An Exploratory Study Using Prospective Data From UK Primary Care (2023)
Journal Article
Harrisson, S. A., Ogollah, R., Dunn, K. M., Foster, N. E., & Konstantinou, K. (2024). Prognosis of Patients With Neuropathic Low Back-Related Leg Pain: An Exploratory Study Using Prospective Data From UK Primary Care. The Journal of Pain, 25(2), 533-544. https://doi.org/10.1016/j.jpain.2023.09.016

This prospective cohort study investigates the prognosis of patients with neuropathic low back-related leg pain (LBLP) consulting in UK primary care. Data from 511 patients were collected using standardised baseline clinical examinations (including M... Read More about Prognosis of Patients With Neuropathic Low Back-Related Leg Pain: An Exploratory Study Using Prospective Data From UK Primary Care.

Clinicians’ views of prescribing oral and intravenous bisphosphonates for osteoporosis: a qualitative study (2023)
Journal Article
Bishop, S., Narayanasamy, M. J., Paskins, Z., Corp, N., Bastounis, A., Griffin, J., Gittoes, N., Leonardi-Bee, J., Langley, T., & Sahota, O. (2023). Clinicians’ views of prescribing oral and intravenous bisphosphonates for osteoporosis: a qualitative study. BMC Musculoskeletal Disorders, 24(1), Article 770. https://doi.org/10.1186/s12891-023-06865-1

Background: Bisphosphonate medications, including alendronate, ibandronate and risedronate administered orally and zoledronate, administered intravenously, are commonly prescribed for the treatment of osteoporosis based on evidence that, correctly ta... Read More about Clinicians’ views of prescribing oral and intravenous bisphosphonates for osteoporosis: a qualitative study.

Exploring the perspectives of community members on use of Nyaope in Tshwane, South Africa (2023)
Journal Article
Nzaumvila, D. K., Mash, R., & Helliwell, T. (in press). Exploring the perspectives of community members on use of Nyaope in Tshwane, South Africa. South African Family Practice, 65(1), https://doi.org/10.4102/safp.v65i1.5715

Background: Substance use is a major public health issue in South Africa. Cocktails, containing two or more low-quality substances, have been reported. Nyaope is one of the most popular and is widely available. It has a significant impact on users an... Read More about Exploring the perspectives of community members on use of Nyaope in Tshwane, South Africa.

GPER acts through the cAMP/Epac/JNK/AP-1 pathway to induce transcription of alpha 2C adrenoceptor in human microvascular smooth muscle cells. (2023)
Journal Article
Fardoun, M., Nasser, S. A., El-Yazbi, A. F., & Eid, A. H. (2023). GPER acts through the cAMP/Epac/JNK/AP-1 pathway to induce transcription of alpha 2C adrenoceptor in human microvascular smooth muscle cells. Journal of Cardiovascular Pharmacology, 82(6), 470-479. https://doi.org/10.1097/FJC.0000000000001489

Raynaud's phenomenon (RP), which results from exaggerated cold-induced vasoconstriction, is more prevalent in females than males. We previously showed that estrogen increases the expression of alpha 2C-adrenoceptors (α2C-AR), the sole mediator of col... Read More about GPER acts through the cAMP/Epac/JNK/AP-1 pathway to induce transcription of alpha 2C adrenoceptor in human microvascular smooth muscle cells..

The effect of distal aspiration catheter position on collateral flow in mechanical thrombectomy - an in vitro study (2023)
Journal Article
Jakobek, W., Gravino, G., Nayak, S., Yang, Y., Ranjbar, J., & Roffe, C. (in press). The effect of distal aspiration catheter position on collateral flow in mechanical thrombectomy - an in vitro study. Interventional Neuroradiology, https://doi.org/10.1177/15910199231201518

Endovascular mechanical thrombectomy for ischaemic stroke is one of the most effective treatments. Despite the devices and techniques that have been developed, thrombi are not always successfully retrieved. The incidence of futile reperfusion after s... Read More about The effect of distal aspiration catheter position on collateral flow in mechanical thrombectomy - an in vitro study.

Physiotherapists’ Ethical Climate and Work Satisfaction: A STROBE-Compliant Cross-Sectional Study (2023)
Journal Article
Sillero Sillero, A., Ayuso Margañon, R., Moreno-Segura, N., Carrasco, J. J., Atef, H., Ayuso Margañon, S., & Marques-Sule, E. (2023). Physiotherapists’ Ethical Climate and Work Satisfaction: A STROBE-Compliant Cross-Sectional Study. Healthcare, 11(19), Article 2631. https://doi.org/10.3390/healthcare11192631

(1) Background: This study aimed to examine the relationship between Spanish physical therapists’ perceptions of the ethical climate, their moral sensitivity (awareness of ethical issues), and job satisfaction.

(2) Methods: the study analyzed des... Read More about Physiotherapists’ Ethical Climate and Work Satisfaction: A STROBE-Compliant Cross-Sectional Study.