Synthetic Site-Selectively Mono-6-<i>O</i>-Sulfated Heparan Sulfate Dodecasaccharide Shows Anti-Angiogenic Properties <i>In Vitro</i> and Sensitizes Tumors to Cisplatin <i>In Vivo</i>
(2016)
Journal Article
Avizienyte, E., Cole, C. L., Rushton, G., Miller, G. J., Bugatti, A., Presta, M., …Jayson, G. C. (2016). Synthetic Site-Selectively Mono-6-O-Sulfated Heparan Sulfate Dodecasaccharide Shows Anti-Angiogenic Properties In Vitro and Sensitizes Tumors to Cisplatin In Vivo. PloS one, 11(8), Article ARTN e0159739. https://doi.org/10.1371/journal.pone.0159739
Heparan sulphate (HS), a ubiquitously expressed glycosaminoglycan (GAG), regulates multiple cellular functions by mediating interactions between numerous growth factors and their cell surface cognate receptors. However, the structural specificity of... Read More about Synthetic Site-Selectively Mono-6-<i>O</i>-Sulfated Heparan Sulfate Dodecasaccharide Shows Anti-Angiogenic Properties <i>In Vitro</i> and Sensitizes Tumors to Cisplatin <i>In Vivo</i>.