Outputs (2)

The development of anti-angiogenic heparan sulfate oligosaccharides (2014)
Journal Article
Jayson, G. C., Miller, G. J., Hansen, S. U., Barath, M., Gardiner, J. M., & Avizienyte, E. (2014). The development of anti-angiogenic heparan sulfate oligosaccharides. Biochemical Society Transactions, 42(6), 1596 -1600. https://doi.org/10.1042/BST20140229

Angiogenesis has emerged as a novel target for anti-cancer therapies through randomized clinical trials that tested the benefit of adding vascular endothelial growth factor (VEGF) inhibitors to conventional cytotoxic therapies. However, despite impro... Read More about The development of anti-angiogenic heparan sulfate oligosaccharides.

Synthesis of a heparin-related GlcN-IdoA sulfation-site variable disaccharide library and analysis by Raman and ROA spectroscopy (2014)
Journal Article
Miller, G. J., Hansen, S. U., Baráth, M., Johannessen, C., Blanch, E. W., Jayson, G. C., & Gardiner, J. M. (2014). Synthesis of a heparin-related GlcN-IdoA sulfation-site variable disaccharide library and analysis by Raman and ROA spectroscopy. Carbohydrate Research, 400, 44 -53. https://doi.org/10.1016/j.carres.2014.06.026

Synthesis of an array of differentially sulfated GlcN–IdoA disaccharides, accessible on good scale, directly from l-iduronate components is described. These are specifically directed to provide the sulfation variability at the key most common biologi... Read More about Synthesis of a heparin-related GlcN-IdoA sulfation-site variable disaccharide library and analysis by Raman and ROA spectroscopy.