Mesoporous Iron Oxide Synthesized Using Poly(styrene-b-acrylic acid-b-ethylene glycol) Block Copolymer Micelles as Templates for Colorimetric and Electrochemical Detection of Glucose.

Tanaka, Shunsuke; Valentino Kaneti, Yusuf; Bhattacharjee, Ripon; Islam, Md. Nazmul; Nakahata, Rina; Abdullah, Nawfel; Yusa, Shin-ichi; Nguyen, Nam-Trung; Shiddiky, Muhammad J.A.; Yamauchi, Yusuke; Hossain, Md.Shahriar A.

Abstract

Herein, we report the soft-templated preparation of mesoporous iron oxide using an asymmetric poly(styrene-b-acrylic acid-b-ethylene glycol) (PS-b-PAA-b-PEG) triblock copolymer. This polymer forms a micelle consisting of a PS core, a PAA shell, and a PEG corona in aqueous solutions, which can serve as a soft template. The mesoporous iron oxide obtained at an optimized calcination temperature of 400 °C exhibited an average pore diameter of 39 nm, with large specific surface area and pore volume of 86.9 m2 g–1 and 0.218 cm3 g–1, respectively. The as-prepared mesoporous iron oxide materials showed intrinsic peroxidase-like activities toward the catalytic oxidation of 3,3′,5,5′-tertamethylbenzidine (TMB) in the presence of hydrogen peroxide (H2O2). This mimetic feature was further exploited to develop a simple colorimetric (naked-eye) and electrochemical assay for the detection of glucose. Both our colorimetric (naked-eye and UV–vis) and electrochemical assays estimated the glucose concentration to be in the linear range from 1.0 μM to 100 μM with a detection limit of 1.0 μM. We envisage that our integrated detection platform for H2O2 and glucose will find a wide range of applications in developing various biosensors in the field of personalized medicine, food-safety detection, environmental-pollution control, and agro-biotechnology.

Citation

Tanaka, S., Valentino Kaneti, Y., Bhattacharjee, R., Islam, M. N., Nakahata, R., Abdullah, N., Yusa, S.-I., Nguyen, N.-T., Shiddiky, M. J., Yamauchi, Y., & Hossain, M. A. (2017). Mesoporous Iron Oxide Synthesized Using Poly(styrene-b-acrylic acid-b-ethylene glycol) Block Copolymer Micelles as Templates for Colorimetric and Electrochemical Detection of Glucose. ACS applied materials & interfaces, 10(1), https://doi.org/10.1021/acsami.7b13835

• Journal Article Type: Article
• Acceptance Date: Nov 29, 2017
• Online Publication Date: Dec 19, 2017
• Publication Date: Dec 19, 2017
• Deposit Date: Jun 25, 2025
• Journal: ACS applied materials & interfaces
• Print ISSN: 1944-8244
• Electronic ISSN: 1944-8252
• Publisher: American Chemical Society
• Peer Reviewed: Peer Reviewed
• Volume: 10
• Issue: 1
• DOI: https://doi.org/10.1021/acsami.7b13835
• Keywords: mesoporous metal oxides; iron oxide; block copolymers; soft-template; glucose detection
• Public URL: https://keele-repository.worktribe.com/output/1054014
• Publisher URL: https://pubs.acs.org/doi/10.1021/acsami.7b13835