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Revascularization for Left Anterior Descending Artery Stenosis: A Review of the Evidence That Supports Practice

Mamas

Revascularization for Left Anterior Descending Artery Stenosis: A Review of the Evidence That Supports Practice Thumbnail


Authors



Abstract

Disease of the proximal left anterior descending (LAD) artery is a common pathological finding often combined with disease in other coronary arteries. In this article we review specifically the evidence (and the guidelines arising from the data) for lesions isolated to the proximal LAD only. Critical review of the data reveals limitations with few trials that reflect contemporary practice. Much of the data are observational rather than from randomized trials, and therefore subject to bias. We identified two randomized trials of drug-eluting stents versus left internal mammary artery grafting for isolated lesions of the proximal LAD. One reported no difference in major adverse cardiovascular events, but at an early time-point (6-months), which is likely to be too early to reveal treatment differences. In the second trial, target lesion revascularization excess was noted in the drug-eluting stent arm. Therefore, at the current time, there is little data available to inform interventional cardiologists as to the best revascularization strategy for isolated lesions of the proximal LAD. Further randomized, controlled trials are needed.

Citation

Mamas. (2016). Revascularization for Left Anterior Descending Artery Stenosis: A Review of the Evidence That Supports Practice. Cardiology in Review, https://doi.org/10.1097/CRD.0000000000000097

Acceptance Date Oct 1, 2015
Publication Date Jan 12, 2016
Journal Cardiology in Review
Print ISSN 1061-5377
Publisher Lippincott, Williams & Wilkins
DOI https://doi.org/10.1097/CRD.0000000000000097
Keywords Proximal left anterior descending artery, left internal mammary artery, drug eluting stent, bare metal stent, percutaneous coronary intervention, coronary artery bypass grafting
Publisher URL http://dx.doi.org/10.1097/CRD.0000000000000097