Ageing in the musculoskeletal system

Roberts, Sally; Colombier, Pauline; Sowman, Aneka; Mennan, Claire; Rölfing, Jan H D; Guicheux, Jérôme; Edwards, James R

Abstract

The extent of ageing in the musculoskeletal system during the life course affects the quality and length of life. Loss of bone, degraded articular cartilage, and degenerate, narrowed intervertebral discs are primary features of an ageing skeleton, and together they contribute to pain and loss of mobility. This review covers the cellular constituents that make up some key components of the musculoskeletal system and summarizes discussion from the 2015 Aarhus Regenerative Orthopaedic Symposium (AROS) (Regeneration in the Ageing Population) about how each particular cell type alters within the ageing skeletal microenvironment.

Citation

Roberts, S., Colombier, P., Sowman, A., Mennan, C., Rölfing, J. H. D., Guicheux, J., & Edwards, J. R. (2016). Ageing in the musculoskeletal system. Acta orthopaedica, 87(S363), 15- 25. https://doi.org/10.1080/17453674.2016.1244750

• Journal Article Type: Article
• Acceptance Date: Jun 14, 2016
• Online Publication Date: Dec 16, 2016
• Publication Date: Oct 17, 2016
• Journal: Acta Orthopaedica
• Print ISSN: 1745-3674
• Publisher: Informa Healthcare
• Peer Reviewed: Peer Reviewed
• Volume: 87
• Issue: S363
• Pages: 15- 25
• DOI: https://doi.org/10.1080/17453674.2016.1244750
• Publisher URL: https://doi.org/10.1080/17453674.2016.1244750