Isolation and characterisation of mesenchymal stem cells from different regions of the human umbilical cord.

Mennan, Claire; Wright, Karina; Bhattacharjee, Atanu; Balain, Birender; Richardson, James; Roberts, Sally

Abstract

Umbilical cords as a source of stem cells are of increasing interest for cell therapies as they present little ethical consideration and are reported to contain immune privileged cells which may be suitable for allogeneic based therapies. Mesenchymal stem cells (MSCs) sourced from several different cord regions, including artery, vein, cord lining, and Wharton's jelly, are described in the literature. However, no one study has yet isolated and characterised MSCs from all regions of the same cord to determine the most suitable cells for cell based therapeutics.

Citation

Mennan, C., Wright, K., Bhattacharjee, A., Balain, B., Richardson, J., & Roberts, S. (2013). Isolation and characterisation of mesenchymal stem cells from different regions of the human umbilical cord. BioMed Research International, 2013, Article 916136. https://doi.org/10.1155/2013/916136

• Journal Article Type: Article
• Acceptance Date: Jun 13, 2013
• Publication Date: Jun 13, 2013
• Journal: BioMed Research International
• Print ISSN: 2314-6133
• Publisher: Hindawi
• Peer Reviewed: Peer Reviewed
• Volume: 2013
• Article Number: 916136
• DOI: https://doi.org/10.1155/2013/916136
• Keywords: cell differentiation, cell proliferation, cell separation, chondrogenesis, dissection, flow cytometry, humans, mesenchymal stromal cells, umbilical cord
• Publisher URL: http://dx.doi.org/10.1155/2013/916136