Biological challenges for regeneration of the degenerated disc using cellular therapies.pdf
(3.4 Mb)
PDF
Biological challenges for regeneration of the degenerated disc using cellular therapies
Abstract
In this review, we discuss some of the challenges in successful cellular repair of the disc. We fi rst review the function, organization, and composition of a normal disc, outline the changes that occur in degeneration, and consider how these might infl uence function. We then summarize cell therapy approaches to repairing the disc in relation to the choice of cells and cell support. We outline the challenges facing the implanted cells in the degenerate disc, and ask whether these therapies can be evaluated in animal models. Finally, we outline the important, but often neglected, problem of patient selection.
Citation
(2016). Biological challenges for regeneration of the degenerated disc using cellular therapies. Acta orthopaedica, 39 -46. https://doi.org/10.1080/17453674.2017.1297916
Acceptance Date | Jan 17, 2017 |
---|---|
Publication Date | Dec 16, 2016 |
Journal | Acta Orthopaedica |
Print ISSN | 1745-3674 |
Publisher | Informa Healthcare |
Pages | 39 -46 |
DOI | https://doi.org/10.1080/17453674.2017.1297916 |
Publisher URL | http://dx.doi.org/10.1080/17453674.2017.1297916 |
Files
Downloadable Citations
About Keele Repository
Administrator e-mail: research.openaccess@keele.ac.uk
This application uses the following open-source libraries:
SheetJS Community Edition
Apache License Version 2.0 (http://www.apache.org/licenses/)
PDF.js
Apache License Version 2.0 (http://www.apache.org/licenses/)
Font Awesome
SIL OFL 1.1 (http://scripts.sil.org/OFL)
MIT License (http://opensource.org/licenses/mit-license.html)
CC BY 3.0 ( http://creativecommons.org/licenses/by/3.0/)
Powered by Worktribe © 2025
Advanced Search