Aluminium in human brain tissue: how much is too much?

Abstract

A burgeoning body of research confirms and affirms the presence of aluminium in human brain tissue. Recently, the first data on aluminium content of brain tissue from donors with diagnoses of familial Alzheimer's disease, autism spectrum disorder, multiple sclerosis and epilepsy have been published. Quantitative data are supported by aluminium-specific fluorescence microscopy identifying the locations of aluminium in human brain tissue. The challenge in the future will be to confirm or refute the role played by brain aluminium intoxication in human neurodegenerative disease.

Citation

(2019). Aluminium in human brain tissue: how much is too much?. Journal of Biological Inorganic Chemistry, 1279-1282. https://doi.org/10.1007/s00775-019-01710-0

• Acceptance Date: Aug 10, 2019
• Publication Date: Dec 1, 2019
• Journal: Journal of Biological Inorganic Chemistry
• Print ISSN: 0949-8257
• Publisher: Springer Verlag
• Pages: 1279-1282
• DOI: https://doi.org/10.1007/s00775-019-01710-0
• Keywords: aluminium in brain tissue; Alzheimer's disease; Autism; Multiple sclerosis; Epilepsy; Aluminium-specific fluroescence microscopy; Neurodegenerative disease
• Publisher URL: https://link.springer.com/article/10.1007%2Fs00775-019-01710-0