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AMPA receptors control fear extinction through an Arc-dependent mechanism

Trent, Simon

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Abstract

Activity-regulated cytoskeleton-associated protein (Arc) supports fear memory through synaptic plasticity events requiring actin cytoskeleton rearrangements. We have previously shown that reducing hippocampal Arc levels through antisense knockdown leads to the premature extinction of contextual fear. Here we show that the AMPA receptor antagonist CNQX elevates hippocampal Arc levels during extinction and blocks extinction that can be rescued by reducing Arc. Increasing Arc levels with CNQX also overcomes the actin-destabilizing properties of cytochalasin D and promotes extinction. Therefore, extinction is dependent on AMPA-mediated reductions of Arc via a mechanism consistent with a role for Arc in stabilizing the actin cytoskeleton to constrain extinction.

Citation

Trent, S., Barnes, P., Hall, J., & Thomas, K. L. (2017). AMPA receptors control fear extinction through an Arc-dependent mechanism. Learning & Memory, 24(8), 375 - 380. https://doi.org/10.1101/lm.045013.117

Journal Article Type Article
Acceptance Date Apr 21, 2017
Online Publication Date Jul 17, 2017
Publication Date 2017-08
Journal Learning & Memory
Print ISSN 1072-0502
Publisher Cold Spring Harbor Laboratory Press
Peer Reviewed Peer Reviewed
Volume 24
Issue 8
Pages 375 - 380
DOI https://doi.org/10.1101/lm.045013.117
Keywords AMPA receptors, Arc-dependent mechanism
Publisher URL http://learnmem.cshlp.org/content/24/8/375

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