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Hippocampal Regulation of Postsynaptic Density Homer1 by Associative Learning

Clifton, Nicholas E.; Cameron, Darren; Trent, Simon; Sykes, Lucy H.; Thomas, Kerrie L.; Hall, Jeremy

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Authors

Nicholas E. Clifton

Darren Cameron

Lucy H. Sykes

Kerrie L. Thomas

Jeremy Hall



Abstract

<jats:p>Genes involved in synaptic plasticity, particularly genes encoding postsynaptic density proteins, have been recurrently linked to psychiatric disorders including schizophrenia and autism. Postsynaptic density Homer1 proteins contribute to synaptic plasticity through the competing actions of short and long isoforms. The activity-induced expression of short<jats:italic>Homer1</jats:italic>isoforms,<jats:italic>Homer1a</jats:italic>and<jats:italic>Ania-3</jats:italic>, is thought to be related to processes of learning and memory. However, the precise regulation of<jats:italic>Homer1a</jats:italic>and<jats:italic>Ania-3</jats:italic>with different components of learning has not been investigated. Here, we used in situ hybridization to quantify short and long<jats:italic>Homer1</jats:italic>expression in the hippocampus following consolidation, retrieval, and extinction of associative fear memory, using contextual fear conditioning in rats.<jats:italic>Homer1a</jats:italic>and<jats:italic>Ania-3</jats:italic>, but not long<jats:italic>Homer1</jats:italic>, were regulated by contextual fear learning or novelty detection, although their precise patterns of expression in hippocampal subregions were dependent on the isoform. We also show for the first time that the two short Homer1 isoforms are regulated after the retrieval and extinction of contextual fear memory, albeit with distinct temporal and spatial profiles. These findings support a role of activity-induced Homer1 isoforms in learning and memory processes in discrete hippocampal subregions and suggest that Homer1a and Ania-3 may play separable roles in synaptic plasticity.</jats:p>

Journal Article Type Article
Acceptance Date Oct 10, 2017
Publication Date Nov 7, 2017
Journal Neural Plasticity
Print ISSN 2090-5904
Publisher Hindawi
Peer Reviewed Peer Reviewed
Volume 2014
Article Number 5959182
Pages 1 - 11
DOI https://doi.org/10.1155/2017/5959182
Keywords Hippocampal Regulation, Postsynaptic Density, Homer1, Associative Learning
Publisher URL https://www.hindawi.com/journals/np/2017/5959182/

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