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A Reversibly Porous Supramolecular Peptide Framework**

Brightwell, Dominic F.; Truccolo, Giada; Samanta, Kushal; Fenn, Elliott J.; Holder, Simon J.; Shepherd, Helena J.; Hawes, Chris S.; Palma, Aniello

A Reversibly Porous Supramolecular Peptide Framework** Thumbnail


Authors

Dominic F. Brightwell

Giada Truccolo

Kushal Samanta

Elliott J. Fenn

Simon J. Holder

Helena J. Shepherd

Aniello Palma



Abstract

The ability to use bio‐inspired building blocks in the assembly of novel supramolecular frameworks is at the forefront of an exciting research field. Herein, we present the first polyproline helix to self‐assemble into a reversibly porous, crystalline, supramolecular peptide framework (SPF). This framework is assembled from a short oligoproline, adopting the polyproline II conformation, driven by hydrogen‐bonding and dispersion interactions. Thermal activation, guest‐induced dynamic porosity and enantioselective guest inclusion have been demonstrated for this novel system. The principles of the self‐assembly associated with this SPF will be used as a blueprint allowing for the further development of helical peptide linkers in the rational design of SPFs and metal‐peptide frameworks.

Citation

Brightwell, D. F., Truccolo, G., Samanta, K., Fenn, E. J., Holder, S. J., Shepherd, H. J., …Palma, A. (2022). A Reversibly Porous Supramolecular Peptide Framework**. Chemistry - A European Journal, 28(66), https://doi.org/10.1002/chem.202202368

Journal Article Type Article
Acceptance Date Aug 30, 2022
Online Publication Date Sep 1, 2023
Publication Date Aug 30, 2022
Publicly Available Date May 30, 2023
Journal Chemistry – A European Journal
Print ISSN 0947-6539
Publisher Wiley
Volume 28
Issue 66
DOI https://doi.org/10.1002/chem.202202368
Keywords General Chemistry, Catalysis, Organic Chemistry
Publisher URL https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/chem.202202368

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