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A comprehensive review of quantum bioreactor cell manufacture: Research and clinical applications

Hulme, Charlotte H.; Mennan, Claire; McCarthy, Helen S.; Davies, Rebecca; Lan, Tian; Rix, Larissa; Perry, Jade; Wright, Karina

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Authors

Rebecca Davies

Tian Lan

Larissa Rix



Abstract

The Quantum cell expansion system manufactured by Terumo-BCT is perhaps the most widely reported Good Manufacturing Practice–compliant bioreactor used for the expansion of adherent cell populations, both for research purposes and clinical cell–based therapies/trials. Although the system was originally designed for adherent cell expansion, more recently suspension cultures and extracellular vesicle manufacturing protocols have been published using the Quantum system. Cell therapy research and regenerative medicine in general is a rapidly expanding field and as such it is likely that the use of this system will become even more widespread and perhaps mandatory, for both research and development and in the clinic. The purpose of this review is to describe, compare and discuss the diverse range of research and clinical applications currently using the Quantum system, which to our knowledge has not previously been reviewed. In addition, current and future challenges will also be discussed.

Journal Article Type Review
Acceptance Date Apr 10, 2023
Online Publication Date Sep 22, 2023
Publication Date May 9, 2023
Journal Cytotherapy
Print ISSN 1465-3249
Publisher Elsevier
Volume 25
Issue 10
Pages 1017-1026
DOI https://doi.org/10.1016/j.jcyt.2023.04.004
Keywords bioreactor; cell therapy; extracellular vesicles; Good Manufacturing Practice; Quantum; up-scale manufacture
Publisher URL https://www.sciencedirect.com/science/article/pii/S146532492300097X?via%3Dihub

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