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Expanding the family of tetrahalide iron complexes: Synthesis, structure and biological applications

Abedin, Nusrat; Alshehri, Abdullah Hamed A.; Almughrbi, Ali M.A.; Moore, Olivia; Alyza, Sheikh; Rusbridge, Elizabeth K.; Masood, Naqash; Egbowon, Biola F.; Hargreaves, Alan J.; Dafhnis-Calas, Felix; Fitzpatrick, Anthony J.

Authors

Nusrat Abedin

Abdullah Hamed A. Alshehri

Ali M.A. Almughrbi

Olivia Moore

Sheikh Alyza

Elizabeth K. Rusbridge

Naqash Masood

Biola F. Egbowon

Alan J. Hargreaves

Felix Dafhnis-Calas

Anthony J. Fitzpatrick



Abstract

A neutral octahedral mononuclear iron(II) tetrabromide complex, [Fe(HAmpy)2Br4], that consists of equatorial bromide and protonated aminopyrazinium axial ligands is successfully synthesised through redox chemistry and analysed using X-ray crystallography. The iron(II) oxidation state is balanced by the protonated pyrazinium nitrogen just outside the coordination sphere. The biological properties of this and two other related complexes are investigated using both Gram-negative and Gram-positive bacteria as well as methicillin resistant strains. They all exhibit some antimicrobial properties albeit at moderate to poor concentrations. However, the tetrahalide complexes analysed exhibit excellent anti-biofilm properties well below cytotoxic levels.

Citation

Abedin, N., Alshehri, A. H. A., Almughrbi, A. M., Moore, O., Alyza, S., Rusbridge, E. K., …Fitzpatrick, A. J. (2020). Expanding the family of tetrahalide iron complexes: Synthesis, structure and biological applications. Polyhedron, 190, 114755. https://doi.org/10.1016/j.poly.2020.114755

Journal Article Type Article
Publication Date 2020-11
Deposit Date May 30, 2023
Journal Polyhedron
Print ISSN 0277-5387
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 190
Pages 114755
DOI https://doi.org/10.1016/j.poly.2020.114755
Keywords Materials Chemistry; Inorganic Chemistry; Physical and Theoretical Chemistry
Additional Information This article is maintained by: Elsevier; Article Title: Expanding the family of tetrahalide iron complexes: Synthesis, structure and biological applications; Journal Title: Polyhedron; CrossRef DOI link to publisher maintained version: https://doi.org/10.1016/j.poly.2020.114755; Content Type: article; Copyright: © 2020 Elsevier Ltd. All rights reserved.