Skip to main content

Research Repository

Advanced Search

Inhibition of branched-chain alpha-keto acid dehydrogenase kinase augments the sensitivity of ovarian and breast cancer cells to paclitaxel

Ibrahim, Suad Lateef; Abed, Mohammed Najim; Mohamed, Gehad; Price, Joshua C.; Abdullah, Marwan Ibrahim; Richardson, Alan

Authors

Suad Lateef Ibrahim

Mohammed Najim Abed

Gehad Mohamed

Joshua C. Price

Marwan Ibrahim Abdullah



Abstract

Many cancer patients who initially respond to chemotherapy eventually develop chemoresistance, and to address this,
we previously conducted a RNAi screen to identify genes contributing to resistance. One of the hits from the screen was branchedchain α-keto acid dehydrogenase kinase (BCKDK). BCKDK controls the metabolism of branched-chain amino acids (BCAAs) through
phosphorylation and inactivation of the branched-chain α-keto acid dehydrogenase complex (BCKDH), thereby inhibiting
catabolism of BCAAs

Citation

Ibrahim, S. L., Abed, M. N., Mohamed, G., Price, J. C., Abdullah, M. I., & Richardson, A. (2023). Inhibition of branched-chain alpha-keto acid dehydrogenase kinase augments the sensitivity of ovarian and breast cancer cells to paclitaxel. British Journal of Cancer, 128(5), 896-906. https://doi.org/10.1038/s41416-022-02095-9

Journal Article Type Article
Acceptance Date Dec 16, 2022
Online Publication Date Dec 16, 2022
Publication Date Mar 23, 2023
Deposit Date Jun 1, 2023
Journal British Journal of Cancer
Print ISSN 0007-0920
Electronic ISSN 1532-1827
Publisher Cancer Research UK
Peer Reviewed Peer Reviewed
Volume 128
Issue 5
Pages 896-906
DOI https://doi.org/10.1038/s41416-022-02095-9
Keywords Cancer Research; Oncology
Public URL https://keele-repository.worktribe.com/output/434077
Publisher URL https://www.nature.com/articles/s41416-022-02095-9
Additional Information Received: 25 August 2022; Revised: 24 November 2022; Accepted: 28 November 2022; First Online: 16 December 2022; : The authors declare no competing interests.; : Not applicable.