Suad Lateef Ibrahim
Inhibition of branched-chain alpha-keto acid dehydrogenase kinase augments the sensitivity of ovarian and breast cancer cells to paclitaxel
Ibrahim, Suad Lateef; Abed, Mohammed Najim; Mohamed, Gehad; Price, Joshua C.; Abdullah, Marwan Ibrahim; Richardson, Alan
Authors
Mohammed Najim Abed
Gehad Mohamed
Joshua C. Price
Marwan Ibrahim Abdullah
Alan Richardson a.richardson1@keele.ac.uk
Abstract
Many cancer patients who initially respond to chemotherapy eventually develop chemoresistance, and to address this,
we previously conducted a RNAi screen to identify genes contributing to resistance. One of the hits from the screen was branchedchain α-keto acid dehydrogenase kinase (BCKDK). BCKDK controls the metabolism of branched-chain amino acids (BCAAs) through
phosphorylation and inactivation of the branched-chain α-keto acid dehydrogenase complex (BCKDH), thereby inhibiting
catabolism of BCAAs
Citation
Ibrahim, S. L., Abed, M. N., Mohamed, G., Price, J. C., Abdullah, M. I., & Richardson, A. (2023). Inhibition of branched-chain alpha-keto acid dehydrogenase kinase augments the sensitivity of ovarian and breast cancer cells to paclitaxel. British Journal of Cancer, 128(5), 896-906. https://doi.org/10.1038/s41416-022-02095-9
Journal Article Type | Article |
---|---|
Acceptance Date | Dec 16, 2022 |
Online Publication Date | Dec 16, 2022 |
Publication Date | Mar 23, 2023 |
Deposit Date | Jun 1, 2023 |
Journal | British Journal of Cancer |
Print ISSN | 0007-0920 |
Electronic ISSN | 1532-1827 |
Publisher | Cancer Research UK |
Peer Reviewed | Peer Reviewed |
Volume | 128 |
Issue | 5 |
Pages | 896-906 |
DOI | https://doi.org/10.1038/s41416-022-02095-9 |
Keywords | Cancer Research; Oncology |
Public URL | https://keele-repository.worktribe.com/output/434077 |
Publisher URL | https://www.nature.com/articles/s41416-022-02095-9 |
Additional Information | Received: 25 August 2022; Revised: 24 November 2022; Accepted: 28 November 2022; First Online: 16 December 2022; : The authors declare no competing interests.; : Not applicable. |
You might also like
Ivermectin Augments the Anti-Cancer Activity of Pitavastatin in Ovarian Cancer Cells
(2023)
Journal Article
Identification of foods that affect the anti-cancer activity of pitavastatin in cells
(2022)
Journal Article
Downloadable Citations
About Keele Repository
Administrator e-mail: research.openaccess@keele.ac.uk
This application uses the following open-source libraries:
SheetJS Community Edition
Apache License Version 2.0 (http://www.apache.org/licenses/)
PDF.js
Apache License Version 2.0 (http://www.apache.org/licenses/)
Font Awesome
SIL OFL 1.1 (http://scripts.sil.org/OFL)
MIT License (http://opensource.org/licenses/mit-license.html)
CC BY 3.0 ( http://creativecommons.org/licenses/by/3.0/)
Powered by Worktribe © 2025
Advanced Search