Simple Calix[n]arenes and Calix[4]resorcinarenes as Drug Solubilizing Agents

Hoskins, Clare; Curtis, Anthony D.M.

Abstract

Many drug molecules have low solubility in aqueous media and, hence, poor bioavailability. The formation of a host-guest complex with some other compound which has a good solubility profile can facilitate solubilization of hydrophobic drugs. Complex formation relies upon the formation of non-covalent interactions between the host molecule and the drug guest. The use of calix[n]arenes, a well-characterized class of cyclic oligomers, has been investigated for their ability to form complexes with a variety of ionic and molecular species. This review highlights those studies which have demonstrated the potential of calix[n]arenes as host molecules in novel drug delivery systems.

Citation

Hoskins, C., & Curtis, A. D. Simple Calix[n]arenes and Calix[4]resorcinarenes as Drug Solubilizing Agents. Journal of Nanomedicine Research, 2(3), https://doi.org/10.15406/jnmr.2015.02.00028

• Journal Article Type: Article
• Online Publication Date: Apr 20, 2015
• Deposit Date: Jun 12, 2023
• Journal: Journal of Nanomedicine Research
• Publisher: MedCrave Group
• Peer Reviewed: Peer Reviewed
• Volume: 2
• Issue: 3
• DOI: https://doi.org/10.15406/jnmr.2015.02.00028
• Keywords: General Medicine; Calix[n]arene, Calix.4resorcinarene, Drug solubilization