Samantha R Unsworth-White
Immunotherapy for non-muscle-invasive bladder cancer: from the origins of BCG to novel therapies
Unsworth-White, Samantha R; Kitchen, Mark O; Bryan, Richard T
Authors
Mark O Kitchen
Richard T Bryan
Abstract
Supplies of intravesical Bacillus Calmette-Guérin (BCG), the first-line treatment for most intermediate- and high-risk non-muscle-invasive bladder cancers (NMIBC), have proven unreliable over the past decade. This review considers the evolution of BCG immunotherapy for NMIBC: from the discovery of the antitumour side effects of tuberculosis and subsequently the BCG vaccine, to recent advances in novel immunotherapeutic agents. We summarize the evidence for alternative options to standard intravesical BCG therapy regimens and describe the potential for immune response manipulating drugs in the treatment of NMIBC. These new agents, including immune checkpoint inhibitors, toll-like receptor agonists and recombinant viral vectors, may provide better options in the management of NMIBC in the future.
Citation
Unsworth-White, S. R., Kitchen, M. O., & Bryan, R. T. (2022). Immunotherapy for non-muscle-invasive bladder cancer: from the origins of BCG to novel therapies. Future Oncology, 18(1), 105-115. https://doi.org/10.2217/fon-2021-0781
Journal Article Type | Review |
---|---|
Acceptance Date | Jan 1, 2022 |
Online Publication Date | Nov 12, 2021 |
Publication Date | 2022-01 |
Deposit Date | Jun 16, 2023 |
Journal | Future Oncology |
Print ISSN | 1479-6694 |
Electronic ISSN | 1744-8301 |
Publisher | Future Medicine |
Peer Reviewed | Peer Reviewed |
Volume | 18 |
Issue | 1 |
Pages | 105-115 |
DOI | https://doi.org/10.2217/fon-2021-0781 |
Keywords | Cancer Research; Oncology; General Medicine |
Public URL | https://keele-repository.worktribe.com/output/468996 |
Publisher URL | https://www.tandfonline.com/doi/full/10.2217/fon-2021-0781 |
You might also like
Physoxia Influences Global and Gene-Specific Methylation in Pluripotent Stem Cells
(2022)
Journal Article
Downloadable Citations
About Keele Repository
Administrator e-mail: research.openaccess@keele.ac.uk
This application uses the following open-source libraries:
SheetJS Community Edition
Apache License Version 2.0 (http://www.apache.org/licenses/)
PDF.js
Apache License Version 2.0 (http://www.apache.org/licenses/)
Font Awesome
SIL OFL 1.1 (http://scripts.sil.org/OFL)
MIT License (http://opensource.org/licenses/mit-license.html)
CC BY 3.0 ( http://creativecommons.org/licenses/by/3.0/)
Powered by Worktribe © 2024
Advanced Search