Protein phosphatase 4 regulates apoptosis in leukemic and primary human T-cells

Mourtada-Maarabouni, Mirna; Williams, Gwyn T.

Abstract

The control of T-cell survival is of overwhelming importance for preventing leukemia and lymphoma. The present report demonstrates that the serine/threonine protein phosphatase PP4 regulates the survival of both leukemic T-cells and untransformed human peripheral blood T-cells, particularly after treatment with anti-leukemic drugs and other cytotoxic stimuli. PP4-induced apoptosis is mediated, at least in part, through de-phosphorylation of apoptosis regulator PEA-15, previously implicated in the control of leukemic cell survival. PP4 activity significantly affects the mutation rate in leukemic T-cells, indicating that PP4 dysfunction may be important in the development and progression of leukemia.

Citation

Mourtada-Maarabouni, M., & Williams, G. T. (2009). Protein phosphatase 4 regulates apoptosis in leukemic and primary human T-cells. Leukemia Research, 33(11), 1539-1551. https://doi.org/10.1016/j.leukres.2009.05.013

• Journal Article Type: Article
• Acceptance Date: May 12, 2009
• Online Publication Date: Jun 18, 2009
• Publication Date: 2009
• Deposit Date: May 16, 2024
• Journal: Leukemia Research
• Print ISSN: 0145-2126
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 33
• Issue: 11
• Pages: 1539-1551
• ISBN: 01452126
• DOI: https://doi.org/10.1016/j.leukres.2009.05.013
• Public URL: https://keele-repository.worktribe.com/output/543740