RBM5/LUCA-15 — Tumour Suppression by Control of Apoptosis and the Cell Cycle?

Mourtada-Maarabouni, Mirna; Williams, Gwyn T.

Abstract

The candidate tumour suppressor gene, LUCA-15, maps to the lung cancer tumour suppressor locus 3p21.3. The LUCA-15 gene locus encodes at least four alternatively spliced transcripts, which have been shown to function as regulators of apoptosis, a fact that may have a major significance in tumour regulation. This review highlights evidence that implicates the LUCA-15 locus in the control of apoptosis and cell proliferation, and reports observations that significantly strengthen the case for tumour suppressor activity by this gene.

Citation

Mourtada-Maarabouni, M., & Williams, G. T. (2002). RBM5/LUCA-15 — Tumour Suppression by Control of Apoptosis and the Cell Cycle?. Scientific World Journal, 2, https://doi.org/10.1100/tsw.2002.859

• Journal Article Type: Review
• Acceptance Date: May 17, 2002
• Online Publication Date: Jul 4, 2002
• Publication Date: 2002
• Deposit Date: May 15, 2024
• Journal: TheScientificWorldJournal
• Print ISSN: 2356-6140
• Publisher: Hindawi
• Peer Reviewed: Peer Reviewed
• Volume: 2
• ISBN: 1537744X
• DOI: https://doi.org/10.1100/tsw.2002.859
• Public URL: https://keele-repository.worktribe.com/output/543828
• Publisher URL: https://www.hindawi.com/journals/tswj/2002/185316/