Imidazolines and pancreatic hormone secretion

MORGAN, NOEL G.; CHAN, SUE L.F.; MOURTADA, MIRNA; MONKS, LARA K.; RAMSDEN, CHRISTOPHER A.

Abstract

A range of imidazoline derivatives are known to be effective stimulators of insulin secretion, and this response correlates with closure of ATP-sensitive potassium channels in the pancreatic β-cell. However, mounting evidence indicates that potassium channel blockade may form only part of the mechanism by which imidazolines exert their effects on insulin secretion. Additionally, it remains unclear whether members of this class of drugs can bind directly to potassium channel components and whether occupation of a single binding site accounts for their functional activity. This review considers recent developments in the field and highlights evidence that does not fit readily with the concept that a single mechanism of action is sufficient to mediate the effects of imidazolines on pancreatic hormone secretion.

Citation

MORGAN, N. G., CHAN, S. L., MOURTADA, M., MONKS, L. K., & RAMSDEN, C. A. (1999). Imidazolines and pancreatic hormone secretion. Annals of the New York Academy of Sciences, 881(1), 217-228. https://doi.org/10.1111/j.1749-6632.1999.tb09364.x

• Journal Article Type: Article
• Online Publication Date: Feb 6, 2006
• Publication Date: 1999-06
• Deposit Date: Jan 3, 2024
• Journal: Annals of the New York Academy of Sciences
• Print ISSN: 0077-8923
• Electronic ISSN: 1749-6632
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• Volume: 881
• Issue: 1
• Pages: 217-228
• DOI: https://doi.org/10.1111/j.1749-6632.1999.tb09364.x