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Different Continuous Training Intensities Improve Echocardiographic Parameters, Quality of Life, and Functional Capacity in Heart Failure Patients with Reduced Ejection Fraction.

Abdeen, Heba A; Helmy, Zeinab M; Elnaggar, Moustafa I; Aldhahi, Monira I; Taha, Mona Mohamed; Marques-Sule, Elena; Amin, Doaa I; Ibrahim, Bassem S; Abdel Aziz, Ahmed; Castiglione, Vincenzo; Atef, Hady

Authors

Heba A Abdeen

Zeinab M Helmy

Moustafa I Elnaggar

Monira I Aldhahi

Mona Mohamed Taha

Elena Marques-Sule

Doaa I Amin

Bassem S Ibrahim

Ahmed Abdel Aziz

Vincenzo Castiglione



Abstract

Background
Multiple comorbidities and physiological changes play a role in a range of heart failure conditions and influence the most effective approach to exercise-based rehabilitation. This research aimed to examine and compare the outcomes of continuous training at three different intensities, focusing on left ventricular (LV) remodeling, functional capacity, and quality of life among patients with heart failure with reduced ejection fraction (HFrEF).

Methods
In this randomized control trial, a total of 60 male patients (average age: 54.33 ±2.35 years) with HFrEF were randomly allocated into three groups: 1) High-intensity continuous training group (HICT), 2) Moderate-intensity continuous training group (MICT), and 3) Low-intensity continuous training group (LICT). All the training was performed on a bicycle ergometer 3 times/week for 12 weeks. Echocardiographic parameters (left ventricular ejection fraction, left ventricular end-diastolic dimension, left ventricular end-systolic dimension, N-terminal pro-B-type natriuretic peptide (NT-proBNP), quality of life (Minnesota Living with Heart Failure Questionnaire), and functional capacity (6-minute walking test) were assessed before and the end of the study.

Results
The HICT group demonstrated the greatest improvements in all measured variables when compared to the other two groups (P

Conclusion
It was determined that HICT appears to yield the most favorable outcomes in enhancing echocardiographic measures, NT-proBNP levels, quality of life, and functional capacity among HFrEF patients.

Journal Article Type Article
Acceptance Date Aug 10, 2023
Online Publication Date Aug 30, 2023
Publication Date Jan 1, 2023
Deposit Date Sep 21, 2023
Publicly Available Date Sep 21, 2023
Journal International journal of general medicine
Electronic ISSN 1178-7074
Publisher Dove Press
Peer Reviewed Peer Reviewed
Volume 16
Pages 3933-3945
DOI https://doi.org/10.2147/ijgm.s420933
Keywords Quality of life, Ventricular remodeling, Aerobic Exercises, Heart Failure With Reduced Ejection Fraction
PMID 37670928

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