A Modular Approach to Inorganic Phosphazane Macrocycles

Plajer, Alex J.; García‐Rodríguez, Raúl; Benson, Callum G.M.; Matthews, Peter D.; Bond, Andrew D.; Singh, Sanjay; Gade, Lutz H.; Wright, Dominic S.

Abstract

Inorganic macrocycles, based on non-carbon backbones, present exciting synthetic challenges in the systematic assembly of inorganic molecules, as well as new avenues in host–guest and supramolecular chemistry. Here we demonstrate a new high-yielding modular approach to a broad range of trimeric and hexameric S- and Se-bridged inorganic macrocycles based on cyclophosphazane frameworks, using the building blocks [S=(H)P(μ-NR)]2. The method involves the in situ generation of the key intermediate [Eurn:x-wiley:14337851:media:anie201702558:anie201702558-math-0001 (Surn:x-wiley:14337851:media:anie201702558:anie201702558-math-0002 )P(μ-NR)]22−(E=S, Se) dianion, which can be reacted with electrophilic [ClP(μ-NR)]2 to give PIII/PV hexameric rings or reacted with I2 to give trimeric PV variants. Important issues which are highlighted in this work are the competitive bridging ability of S versus Se in these systems and the synthesis of the first air-stable and chiral inorganic macrocycles.

Citation

Plajer, A. J., García‐Rodríguez, R., Benson, C. G., Matthews, P. D., Bond, A. D., Singh, S., …Wright, D. S. (2017). A Modular Approach to Inorganic Phosphazane Macrocycles. Angewandte Chemie International Edition, 56(31), 9087-9090. https://doi.org/10.1002/anie.201702558

• Journal Article Type: Article
• Online Publication Date: Apr 21, 2017
• Publication Date: Jul 24, 2017
• Deposit Date: Mar 1, 2024
• Journal: Angewandte Chemie International Edition
• Print ISSN: 1433-7851
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• Volume: 56
• Issue: 31
• Pages: 9087-9090
• DOI: https://doi.org/10.1002/anie.201702558
• Publisher URL: https://onlinelibrary.wiley.com/doi/10.1002/anie.201702558