P83: A Pilot Study to assess Peak Systolic Velocity as A Possible Marker of Atherosclerotic Burden Using Ultrasound

Koenig, Carola; Atherton, Mark; Cavazzuti, Marco; Ramachandran, Sudarshan; Gomm, Corinna; Strange, Richard; Halliday, Ian; Schenkel, Torsten

Abstract

Introduction: Ischemic heart disease (IHD) has been associated with lower peak systolic velocity (PSV) on penile Doppler measurements [1]. This study establishes whether carotid ultrasound (US) PSV was associated with computational fluid dynamics (CFD) outputs, which in turn may contribute to IHD pathogenesis. Methods: A sample of 57 subjects (with IHD: 27, without IHD: 30) had US velocity profiles (left- common carotid artery) determined between 10–12 equispaced points. Bezier curve fitting was used to fit the profile through the measured velocity points for a normalised diameter. PSV was correlated against CFD results such as wall shear stress (WSS) [2]. Difference in PSV between individuals with/without IHD was studied via t-test. Linear regression was carried out to see if peak systolic velocity was associated with CFD outputs. Any significant associations were analysed within stratified groups (with/without IHD). Results: PSV was significantly lower (p = 0.042) in subjects with IHD (with IHD: 53.6 ± 17.3 cm/s, without IHD: 62.8 ± 16.1 cm/s). PSV was associated with carotid bulb average pressure drop (p < 0.001), area of average bulb WSS (<1 Pa: p = 0.016, <2 Pa: p = 0.006, <3 Pa: p = 0.001). All the above associations remained significant in individuals with IHD (average bulb pressure drop: p = 0.001, average bulb WSS (<1 Pa: p = 0.013, <2Pa: p = 0.008, <3 Pa: p = 0.003). In subjects without IHD, PSV was associated with only average bulb pressure drop (p = 0.016). Conclusions: This study suggests that further work on PSV and its associations with CFD outputs is required in individuals with and without IHD in various vascular beds.

Citation

Koenig, C., Atherton, M., Cavazzuti, M., Ramachandran, S., Gomm, C., Strange, R., …Schenkel, T. (2017). P83: A Pilot Study to assess Peak Systolic Velocity as A Possible Marker of Atherosclerotic Burden Using Ultrasound. Artery Research, 20(C), 76-76. https://doi.org/10.1016/j.artres.2017.10.099

• Journal Article Type: Article
• Online Publication Date: Dec 7, 2019
• Publication Date: Dec 1, 2017
• Deposit Date: Mar 8, 2024
• Journal: Artery Research
• Print ISSN: 1872-9312
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 20
• Issue: C
• Pages: 76-76
• DOI: https://doi.org/10.1016/j.artres.2017.10.099
• Publisher URL: https://www.atlantis-press.com/journals/artres/125930256