CuI-catalyzed cycloisomerization of propargyl amides

Moran, Wesley; Alhalib, Ali

Abstract

The synthesis of substituted dihydrooxazoles by the CuI-catalyzed cycloisomerization of terminal propargyl amides is reported. The reaction has been shown to have good substrate scope and experiments to delineate the mechanism have been performed. Substrates containing a benzylic methylene were oxidized to the ketone under the reaction conditions.

Citation

Moran, W., & Alhalib, A. (2014). CuI-catalyzed cycloisomerization of propargyl amides. Organic and Biomolecular Chemistry, 12(5), 795-800. https://doi.org/10.1039/c3ob42030b

• Journal Article Type: Article
• Acceptance Date: Nov 29, 2013
• Online Publication Date: Dec 2, 2013
• Publication Date: 2014
• Deposit Date: Mar 11, 2024
• Journal: Organic and Biomolecular Chemistry
• Print ISSN: 1477-0520
• Publisher: Royal Society of Chemistry
• Peer Reviewed: Peer Reviewed
• Volume: 12
• Issue: 5
• Pages: 795-800
• DOI: https://doi.org/10.1039/c3ob42030b
• Public URL: https://keele-repository.worktribe.com/output/764013