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Testosterone therapy over 60 months improves aging male symptoms scores in all men with adult-onset testosterone deficiency

Haider, Karim Sultan; Zitzmann, Michael; Ramachandran, Pravinath; König, Carola S; Hackett, Geoffrey; Haider, Ahmad; Saad, Farid; Desnerck, Pieter; Strange, Richard; Mann, Amar; Ramachandran, Sudarshan


Karim Sultan Haider

Michael Zitzmann

Pravinath Ramachandran

Carola S König

Geoffrey Hackett

Ahmad Haider

Farid Saad

Pieter Desnerck

Richard Strange

Amar Mann

Sudarshan Ramachandran


We evaluated change (Δ) in AMSS in men with adult-onset testosterone deficiency (TD) on/not on testosterone undecanoate (TU) by analysing a registry of men with adult-onset TD.

Analyses were performed using non-parametric statistics to determine ΔAMSS at 6–12 monthly intervals in men on/not on TU and movement in AMSS. Factors predicting ΔAMSS were established via linear/multiple regression.

TU was significantly associated with lower AMSS values compared with that at baseline/prior assessment during the initial 42 months treatment; 259 of the 260 men showed improvement. In the 361 men not on TU, AMSS values increased during 60 months of follow-up compared with that at baseline/prior assessment; improvement after 60 months was evident in 1 man, whilst AMSS remained the same or worsened in 213 and 147 men, respectively. In men on TU, baseline AMSS was inversely associated with ΔAMSS (R2 = 0.97), with no other factors reaching significance. Baseline AMSS, age, serum total testosterone (TT), waist circumference (WC), and diastolic blood pressure (BP) were associated with ΔAMSS in men not on TU.

We show that TU was associated with lower AMSS in men with adult-onset TD whilst non-treatment led to increased values. Baseline AMSS values inversely predicted ΔAMSS in both groups.


Haider, K. S., Zitzmann, M., Ramachandran, P., König, C. S., Hackett, G., Haider, A., …Ramachandran, S. (2024). Testosterone therapy over 60 months improves aging male symptoms scores in all men with adult-onset testosterone deficiency. The aging male : the official journal of the International Society for the Study of the Aging Male, 27(1), Article 2357548.

Journal Article Type Article
Acceptance Date May 14, 2024
Online Publication Date May 29, 2024
Publication Date Dec 31, 2024
Deposit Date Jun 14, 2024
Journal The Aging Male
Print ISSN 1368-5538
Electronic ISSN 1473-0790
Publisher Taylor and Francis
Peer Reviewed Peer Reviewed
Volume 27
Issue 1
Article Number 2357548
Keywords Hormone Replacement Therapy - methods, Aging male symptoms score, Humans, adult-onset hypogonadism, metabolic syndrome, testosterone therapy, Wilder Effect, Testosterone - deficiency - blood - analogs & derivatives - therapeutic use - administration & dos
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Publisher URL
Additional Information Peer Review Statement: The publishing and review policy for this title is described in its Aims & Scope.; Aim & Scope:; Received: 2024-03-28; Accepted: 2024-05-14; Published: 2024-05-29