The effect of probiotics supplementation on cancer-treatment complications: a critical umbrella review of interventional meta-analyses

Yang, Zhao; Zhang, Shijie; Ying, Lu; Zhang, Wenjing; Chen, Xiaoyang; Liang, Youfeng; Chen, Ruolan; Yao, Keying; Li, Chunhui; Yu, Changyuan; Jamilian, Parmida; Zarezadeh, Meysam; Kord-Varkaneh, Hamed; Wang, Jianfeng; Li, Hanmin

Abstract

Cancer-related complications pose significant challenges in the management and treatment of patients with malignancies. Several meta-analyses have indicated improving effects of probiotics on cancer complications, while some studies have reported contentious findings. The purpose of the present study was to evaluate the efficacy of probiotics in addressing cancer complications, including diarrhea, mucositis, and infections, following chemotherapy, radiotherapy, and surgery. Relevant studies were searched in the PubMed, Scopus, Embase and Web of Science databases and Google Scholar up to September 2023. All meta-analyses addressing the effects of probiotics on all cancer treatments-induced complications including infection, diarrhea and oral mucositis were included. The pooled results were calculated using a random-effects model. Analyses of subgroups, sensitivity and publication bias were also conducted. The results revealed that the probiotics supplementation was effective on reduction of total cancer complications (OR:0.53; 95% CI: 0.44, 0.62, p < 0.001; I2=79.0%, p < 0.001), total infection rate (OR:0.47; 95%CI: 0.41, 0.52, p < 0.001; I2= 48.8%, p < 0.001); diarrhea (OR:0.50; 95%CI: 0.44, 0.57, p < 0.001; I2=44.4%, p = 0.023) and severe diarrhea (OR: 0.4; 95%CI: 0.27, 0.56, p < 0.001; I2=31.3%, p = 0.178), oral mucositis (OR: 0.76; 95%CI: 0.58, 0.94, p < 0.001; I2=95.5%, p < 0.001) and severe oral mucositis (OR:0.65, 95%CI: 0.58, 0.72 p < 0.001; I2=22.1%, p = 0.274). Multi strain probiotic (OR:0.49; 95%CI: 0.32, 0.65, p < 0.001; I2=90.7%, p < 0.001) were more efficacious than single strain (OR:0.73; 95%CI: 0.66, 0.81, p < 0.001; I2=0.00%, p = 0.786). The findings of the current umbrella meta-analysis provide strong evidence that probiotic supplementation can reduce cancer complications.

Citation

Yang, Z., Zhang, S., Ying, L., Zhang, W., Chen, X., Liang, Y., …Li, H. (in press). The effect of probiotics supplementation on cancer-treatment complications: a critical umbrella review of interventional meta-analyses. Critical Reviews in Food Science and Nutrition, 1-26. https://doi.org/10.1080/10408398.2024.2372880

• Journal Article Type: Review
• Acceptance Date: Jul 13, 2024
• Online Publication Date: Jul 13, 2024
• Deposit Date: Aug 7, 2024
• Journal: Critical Reviews in Food Science and Nutrition
• Print ISSN: 1040-8398
• Publisher: Taylor and Francis
• Peer Reviewed: Peer Reviewed
• Pages: 1-26
• DOI: https://doi.org/10.1080/10408398.2024.2372880
• Keywords: Probiotics; cancer; umbrellameta-analysis
• Public URL: https://keele-repository.worktribe.com/output/880196