Cell-targeting Nanomedicine for Bladder Cancer: A Cellular Bioengineering Approach for Precise Drug Delivery

Hosseini, Zakiyeh Sadat; Zeinalilathori, Somayeh; Fathi-karkan, Sonia; Zeinali, Safieh; Rahdar, Abbas; Siddiqui, Bazla; Kharaba, Zelal; Pandey, Sadanand

Abstract

Bladder cancer poses considerable therapeutic difficulties owing to its elevated rates of recurrence and the constraints of existing treatment methods. This study examines the possibility of cell-targeting nanomedicine as a viable strategy to improve the accuracy of bladder cancer treatment. The article explores the use of carbon-based nanostructures, metallic nanoparticles, and new methods in designing tailored drug delivery systems, drawing on knowledge from cellular bioengineering. This study focuses on the interaction between nanoparticles and the urothelium, with a specific emphasis on the potential of silver nanoparticles (AgNPs) in treating non-muscle invasive bladder cancer (NMIBC). The study highlights how AgNPs may induce apoptosis and stop the cell cycle, offering promising prospects for NMIBC therapy. Furthermore, the use of carbon nanotubes (CNTs) in precise and targeted treatment using photo-thermal ablation is examined. This study highlights the revolutionary capabilities of nanotechnologies, indicating a fundamental change towards improved and individualized therapies for bladder cancer. Therefore, this paper is an essential reference for researchers, physicians, and academics who are committed to progressing cancer therapies.

Citation

Hosseini, Z. S., Zeinalilathori, S., Fathi-karkan, S., Zeinali, S., Rahdar, A., Siddiqui, B., …Pandey, S. (2024). Cell-targeting Nanomedicine for Bladder Cancer: A Cellular Bioengineering Approach for Precise Drug Delivery. Journal of Drug Delivery Science and Technology, 101, Article 160220. https://doi.org/10.1016/j.jddst.2024.106220

• Journal Article Type: Review
• Acceptance Date: Sep 19, 2024
• Online Publication Date: Sep 21, 2024
• Publication Date: Oct 26, 2024
• Deposit Date: Sep 23, 2024
• Publicly Available Date: Sep 23, 2024
• Journal: Journal of Drug Delivery Science and Technology
• Print ISSN: 1773-2247
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 101
• Article Number: 160220
• DOI: https://doi.org/10.1016/j.jddst.2024.106220
• Keywords: Bladder Cancer; Nanomedicine; Drug Delivery; Urothelium; Targeted Therapy
• Public URL: https://keele-repository.worktribe.com/output/924149
• Additional Information: This article is maintained by: Elsevier; Article Title: Cell-targeting Nanomedicine for Bladder Cancer: A Cellular Bioengineering Approach for Precise Drug Delivery; Journal Title: Journal of Drug Delivery Science and Technology; CrossRef DOI link to publisher maintained version: https://doi.org/10.1016/j.jddst.2024.106220; Content Type: article; Copyright: © 2024 Published by Elsevier B.V.