All Outputs (9)

Cytotoxicity effects and apoptosis induction by cycleanine and tetrandrine (2016)
Journal Article
Uche, F. I., Drijfhout, F., McCullagh, J., Richardson, A., & Li, W. W. (2016). Cytotoxicity effects and apoptosis induction by cycleanine and tetrandrine. Planta Medica, 82(S01), https://doi.org/10.1055/s-0036-1596584

Ovarian cancer remains one of the main causes of death in all gynecologic malignancies [1]. Natural products continue to be important sources of clinically approved anti-cancer drugs [2, 3]. Triclisia subcordata Oliv (Menispermeaceae) is a medicinal... Read More about Cytotoxicity effects and apoptosis induction by cycleanine and tetrandrine.

Inhibition of BCKDK increases the sensitivity of ovarian cancer cells to paclitaxel (2016)
Journal Article
Abed, M., & Richardson, A. (2016). Inhibition of BCKDK increases the sensitivity of ovarian cancer cells to paclitaxel. European Journal of Cancer, 69(S1), S20. https://doi.org/10.1016/s0959-8049%2816%2932640-5

Preclinical evaluation of pitavastatin as a treatment for chemotherapy-resistant ovarian cancer (2016)
Journal Article
Robinson, E., Abdullah, M., Jones, S., Menezes, K., Euan, S., Hoskins, C., & Richardson, A. (2016). Preclinical evaluation of pitavastatin as a treatment for chemotherapy-resistant ovarian cancer. European Journal of Cancer, 69(S1), S150. https://doi.org/10.1016/s0959-8049%2816%2933045-3

Bisphosphonates potentiate the activity of pitavastatin against ovarian cancer cells (2016)
Journal Article
Abdullah, M., & Richardson, A. (2016). Bisphosphonates potentiate the activity of pitavastatin against ovarian cancer cells. European Journal of Cancer, 61(S1), S190-S191. https://doi.org/10.1016/s0959-8049%2816%2961674-x

Pitavastatin is a potential treatment for drug-resistant ovarian cancer (2016)
Journal Article
Robinson, E., Jones, S., Menezes, K., Abdullah, M., Stronach, E., Hoskins, C., & Richardson, A. (2016). Pitavastatin is a potential treatment for drug-resistant ovarian cancer. European Journal of Cancer, 61, S192. https://doi.org/10.1016/s0959-8049%2816%2961680-5

Cytotoxicity Effects and Apoptosis Induction by Bisbenzylisoquinoline Alkaloids from Triclisia subcordata (2016)
Journal Article
Uche, F., Drijfhout, F., McCullagh, J., Richardson, A., & Li, W. (2016). Cytotoxicity Effects and Apoptosis Induction by Bisbenzylisoquinoline Alkaloids from Triclisia subcordata. Phytotherapy Research, 1533-1539. https://doi.org/10.1002/ptr.5660

Triclisia subcordata Oliv (Menispermeaceae) is a medicinal plant traditionally used for the treatment of various diseases in West Africa. The ethanol extract of T.?subcordata and its fractions were screened for in vitro anti-ovarian cancer activities... Read More about Cytotoxicity Effects and Apoptosis Induction by Bisbenzylisoquinoline Alkaloids from Triclisia subcordata.

Cytotoxicity effects and apoptosis induction by cycleanine and tetrandrine (2016)
Journal Article
Li, W., & Richardson, A. (2016). Cytotoxicity effects and apoptosis induction by cycleanine and tetrandrine. Phytotherapy Research, 1533-1539. https://doi.org/10.1002/ptr.5660

Triclisia subcordata Oliv (Menispermeaceae) is a medicinal plant traditionally used for the treatment of various diseases in West Africa. The ethanol extract of T.?subcordata and its fractions were screened for in vitro anti-ovarian cancer activities... Read More about Cytotoxicity effects and apoptosis induction by cycleanine and tetrandrine.

Antagonism of Bcl-XL is necessary for synergy between carboplatin and BH3 mimetics in ovarian cancer cells (2016)
Journal Article
Abed, M., Abdullah, M., & Richardson, A. (2016). Antagonism of Bcl-XL is necessary for synergy between carboplatin and BH3 mimetics in ovarian cancer cells. Journal of Ovarian Research, 25 - ?. https://doi.org/10.1186/s13048-016-0234-y

BACKGROUND: BH3 mimetics are a class of drugs that antagonize the Bcl-2 family of apoptosis inhibitors. We have previously shown that these compounds can potentiate the activity of carboplatin against several ovarian cancer cell lines. However, recen... Read More about Antagonism of Bcl-XL is necessary for synergy between carboplatin and BH3 mimetics in ovarian cancer cells.

The BH3 Mimetic Obatoclax Accumulates in Lysosomes and Causes Their Alkalinization. (2016)
Journal Article
Stamelos, V. A., Fisher, N., Bamrah, H., Voisey, C., Price, J. C., Farrell, W. E., …Richardson, A. (in press). The BH3 Mimetic Obatoclax Accumulates in Lysosomes and Causes Their Alkalinization. PloS one, e0150696 - ?. https://doi.org/10.1371/journal.pone.0150696

Obatoclax belongs to a class of compounds known as BH3 mimetics which function as antagonists of Bcl-2 family apoptosis regulators. It has undergone extensive preclinical and clinical evaluation as a cancer therapeutic. Despite this, it is clear that... Read More about The BH3 Mimetic Obatoclax Accumulates in Lysosomes and Causes Their Alkalinization..