Multisite peripheral joint pain: a cross-sectional study of prevalence and impact on general health, quality of life, pain intensity and consultation behaviour

Finney, A; Dziedzic, KSG; Lewis, A; Healey, E

doi:10.1186/s12891-017-1896-3

Open-label randomised pragmatic trial (CONTACT) comparing naproxen and low-dose colchicine for the treatment of gout flares in primary care (2019)
Journal Article
Roddy, E., Clarkson, K., Bucknall, M., Mehta, R., Oppong, R., Avery, A., …Mallen, C. (2019). Open-label randomised pragmatic trial (CONTACT) comparing naproxen and low-dose colchicine for the treatment of gout flares in primary care. Annals of the Rheumatic Diseases, 79(2), https://doi.org/10.1136/annrheumdis-2019-216154

OBJECTIVES: To compare the effectiveness and safety of naproxen and low-dose colchicine for treating gout flares in primary care. METHODS: This was a multicentre open-label randomised trial. Adults with a gout flare recruited from 100 general prac... Read More about Open-label randomised pragmatic trial (CONTACT) comparing naproxen and low-dose colchicine for the treatment of gout flares in primary care.

Determining sample size for progression criteria using hypothesis testing in pragmatic pilot RCTs (2019)
Conference Proceeding
Lewis, M., Bromley, K., McCray, G., Sutton, C., & Lancaster, G. (2019). Determining sample size for progression criteria using hypothesis testing in pragmatic pilot RCTs.

Introduction: The current CONSORT guidelines for reporting of pilot trials do not recommend hypothesis testing of clinical outcomes on the basis of a pilot trial being under-powered to detect such differences and this being the aim of the main tria... Read More about Determining sample size for progression criteria using hypothesis testing in pragmatic pilot RCTs.

Effect-based traffic light progression criteria for pilot studies (2019)
Presentation / Conference
McCray, G., Lewis, M., Bromley, K., & Lancaster, G. (2019, October). Effect-based traffic light progression criteria for pilot studies. Paper presented at 5th International Clinical Trials Methodology Conference (ICTMC 2019), Brighton, UK

Meeting abstract, from the 5th International Clinical Trials Methodology Conference (ICTMC 2019).

Predictors of Functional Outcome in Musculoskeletal Healthcare: An Umbrella Review (2019)
Journal Article
Burgess, R., Mansell, G., Bishop, A., Lewis, M., & Hill, J. (2019). Predictors of Functional Outcome in Musculoskeletal Healthcare: An Umbrella Review. European Journal of Pain, 24(1), 51-70. https://doi.org/10.1002/ejp.1483

BACKGROUND Multiple cohort and systematic review studies exist, reporting independent predictive factors associated with outcome in musculoskeletal populations. These studies have found evidence for a number of 'generic' factors that have been shown... Read More about Predictors of Functional Outcome in Musculoskeletal Healthcare: An Umbrella Review.

Systematic Review of Decision Analytic Modelling in Economic Evaluations of Low Back Pain and Sciatica. (2019)
Journal Article
Hall, J. A., Konstantinou, K., Lewis, M., Oppong, R., Ogollah, R., & Jowett, S. (2019). Systematic Review of Decision Analytic Modelling in Economic Evaluations of Low Back Pain and Sciatica. Applied Health Economics and Health Policy, 17, 467-491. https://doi.org/10.1007/s40258-019-00471-w

BACKGROUND: Low back pain (LBP) and sciatica place significant burden on individuals and healthcare systems, with societal costs alone likely to be in excess of £15 billion. Two recent systematic reviews for LBP and sciatica identified a shortage of... Read More about Systematic Review of Decision Analytic Modelling in Economic Evaluations of Low Back Pain and Sciatica..

Can patients with low health literacy be identified from routine primary care health records? A cross-sectional and prospective analysis. (2019)
Journal Article
Campbell, P., Lewis, M., Chen, Y., Lacey, R., Rowlands, G., & Protheroe, J. (2019). Can patients with low health literacy be identified from routine primary care health records? A cross-sectional and prospective analysis. BMC Family Practice, 101 -?. https://doi.org/10.1186/s12875-019-0994-8

BACKGROUND: People with low health literacy (HL) are at increased risk of poor health outcomes, and receive less benefit from healthcare services. However, healthcare practitioners can effectively adapt healthcare information if they are aware of th... Read More about Can patients with low health literacy be identified from routine primary care health records? A cross-sectional and prospective analysis..

Subgrouping patients with sciatica in primary care for matched care pathways: development of a subgrouping algorithm (2019)
Journal Article
Konstantinou, K., Dunn, K., Windt, D., Ogollah, R., Jasani, V., & Foster, N. (2019). Subgrouping patients with sciatica in primary care for matched care pathways: development of a subgrouping algorithm. BMC Musculoskeletal Disorders, https://doi.org/10.1186/s12891-019-2686-x

Background Sciatica is a painful condition managed by a stepped care approach for most patients. Currently, there are no decision-making tools to guide matching care pathways for patients with sciatica without evidence of serious pathology, early in... Read More about Subgrouping patients with sciatica in primary care for matched care pathways: development of a subgrouping algorithm.

Factors associated with costs and health outcomes in patients with Back and leg pain in primary care: a prospective cohort analysis (2019)
Journal Article
Kigozi, J., Konstantinou, K., Ogollah, R., Dunn, K., Lewis, M., & Jowett, S. (2019). Factors associated with costs and health outcomes in patients with Back and leg pain in primary care: a prospective cohort analysis. BMC Health Services Research, https://doi.org/10.1186/s12913-019-4257-0

Background There is limited research on the economic burden of low back-related leg pain, including sciatica. The aim of this study was to describe healthcare resource utilisation and factors associated with cost and health outcomes in primary care... Read More about Factors associated with costs and health outcomes in patients with Back and leg pain in primary care: a prospective cohort analysis.

Protocol for a multi-centre pilot and feasibility randomised controlled trial with a nested qualitative study: rehabilitation following rotator cuff repair (the RaCeR study) (2019)
Journal Article
Littlewood, C., Bateman, M., Cooke, K., Hennnings, S., Cookson, T., Bromley, K., …Foster, N. E. (2019). Protocol for a multi-centre pilot and feasibility randomised controlled trial with a nested qualitative study: rehabilitation following rotator cuff repair (the RaCeR study). Trials, 20, Article 328. https://doi.org/10.1186/s13063-019-3407-3

Background Shoulder pain is a highly prevalent complaint and disorders of the rotator cuff, including tears, are thought to be the most common cause. The number of operations repair the torn rotator cuff has risen significantly in recent years. Whil... Read More about Protocol for a multi-centre pilot and feasibility randomised controlled trial with a nested qualitative study: rehabilitation following rotator cuff repair (the RaCeR study).

Models used for case-mix adjustment of patient reported outcome measures (PROMs) in musculoskeletal healthcare: A systematic review of the literature. (2019)
Journal Article
Lewis, M., & Hill, J. (2019). Models used for case-mix adjustment of patient reported outcome measures (PROMs) in musculoskeletal healthcare: A systematic review of the literature. Physiotherapy, 137-146. https://doi.org/10.1016/j.physio.2018.10.002

BACKGROUND: Case-mix adjustment is an established method to take account of variations across cohorts in baseline patient factors, when comparing health outcomes. Although commonplace, there is a lack of evidence as to the most appropriate case-mix... Read More about Models used for case-mix adjustment of patient reported outcome measures (PROMs) in musculoskeletal healthcare: A systematic review of the literature..

The impact of inadequate health literacy in a musculoskeletal pain population (2018)
Journal Article
Lacey, R., Campbell, P., Lewis, M., & Protheroe, J. (2018). The impact of inadequate health literacy in a musculoskeletal pain population. https://doi.org/10.3928/24748307-20181101-01

Musculoskeletal conditions are a major cause of ill-health and disability. Inadequate health literacy may partly explain why musculoskeletal self-management programmes are not effective for some patients. This study prospectively evaluates the impact... Read More about The impact of inadequate health literacy in a musculoskeletal pain population.

Uptake of the NICE osteoarthritis guidelines in primary care: a survey of older adults with joint pain (2018)
Journal Article
Healey, E. L., Afolabi, E. K., Lewis, M., Edwards, J. J., Jordan, K. P., Finney, A., …Dziedzic, K. S. (2018). Uptake of the NICE osteoarthritis guidelines in primary care: a survey of older adults with joint pain. BMC Musculoskeletal Disorders, 19, Article 295. https://doi.org/10.1186/s12891-018-2196-2

Background Osteoarthritis (OA) is a leading cause of pain and disability. NICE OA guidelines (2008) recommend that patients with OA should be offered core treatments in primary care. Assessments of OA management have identified a need to improve pri... Read More about Uptake of the NICE osteoarthritis guidelines in primary care: a survey of older adults with joint pain.

A randomised controlled trial of the clinical and cost-effectiveness of ultrasound-guided intra-articular corticosteroid and local anaesthetic injections: the hip injection trial (HIT) protocol (2018)
Journal Article
Paskins, Z., Hughes, G., Myers, H., Hughes, E., Hennings, S., Cherrington, A., …Roddy, E. (2018). A randomised controlled trial of the clinical and cost-effectiveness of ultrasound-guided intra-articular corticosteroid and local anaesthetic injections: the hip injection trial (HIT) protocol. BMC Musculoskeletal Disorders, 19, Article 218. https://doi.org/10.1186/s12891-018-2153-0

BACKGROUND: Evidence on the effectiveness of intra-articular corticosteroid injection for hip osteoarthritis is limited and conflicting. The primary objective of the Hip Injection Trial (HIT) is to compare pain intensity over 6 months, in people with... Read More about A randomised controlled trial of the clinical and cost-effectiveness of ultrasound-guided intra-articular corticosteroid and local anaesthetic injections: the hip injection trial (HIT) protocol.

Optimal primary care management of clinical osteoarthritis and joint pain in older people: a mixed-methods programme of systematic reviews, observational and qualitative studies, and randomised controlled trials (2018)
Report
Hay, E., Dziedzic, K., Foster, N., Peat, G., van der Windt, D., Bartlam, B., …Croft, P. (2018). Optimal primary care management of clinical osteoarthritis and joint pain in older people: a mixed-methods programme of systematic reviews, observational and qualitative studies, and randomised controlled trials. NIHR. PGfAR as project number RP-PG-0407-10386. Secretary of State for Health and Social Care

Background Osteoarthritis (OA) is the most common long-term condition managed in UK general practice. However, care is suboptimal despite evidence that primary care and community-based interventions can reduce OA pain and disability. Objectives Th... Read More about Optimal primary care management of clinical osteoarthritis and joint pain in older people: a mixed-methods programme of systematic reviews, observational and qualitative studies, and randomised controlled trials.

Cost-Utility Analysis of Routine Anxiety and Depression Screening in Patients Consulting for Osteoarthritis: Results From a Clinical, Randomized Controlled Trial (2018)
Journal Article
Kigozi, J., Jowett, S., Nicholl, B. I., Lewis, M., Bartlam, B., Green, D., …Mallen, C. D. (2018). Cost-Utility Analysis of Routine Anxiety and Depression Screening in Patients Consulting for Osteoarthritis: Results From a Clinical, Randomized Controlled Trial. Arthritis Care and Research, 70(12), 1787-1794. https://doi.org/10.1002/acr.23568

OBJECTIVE: To investigate the cost-effectiveness (cost-utility) of introducing general practitioner screening for anxiety and depression in patients consulting with osteoarthritis (OA). METHODS: A cluster-randomised trial-based economic evaluation to... Read More about Cost-Utility Analysis of Routine Anxiety and Depression Screening in Patients Consulting for Osteoarthritis: Results From a Clinical, Randomized Controlled Trial.

Cost-effectiveness of a model consultation to support self-management in patients with osteoarthritis (2018)
Journal Article
Oppong, R., Jowett, S., Lewis, M., Clarkson, K., Paskins, Z., Croft, P., …Dziedzic, K. (2018). Cost-effectiveness of a model consultation to support self-management in patients with osteoarthritis. Rheumatology, 57(6), 1056-1063. https://doi.org/10.1093/rheumatology/key037

Objectives: The aim of this study was to estimate the cost-effectiveness of a model OA consultation for OA to support self-management compared with usual care. Methods: An incremental cost-utility analysis using patient responses to the three-level E... Read More about Cost-effectiveness of a model consultation to support self-management in patients with osteoarthritis.

Clinical course and prognostic factors across different musculoskeletal pain sites: A secondary analysis of individual patient data from randomised clinical trials. (2018)
Journal Article
Green, D., Lewis, M., Mansell, G., Artus, M., Dziedzic, K., Hay, E., …Van Der Windt, D. (2018). Clinical course and prognostic factors across different musculoskeletal pain sites: A secondary analysis of individual patient data from randomised clinical trials. European Journal of Pain, 22(6), 1057-1070. https://doi.org/10.1002/ejp.1190

BACKGROUND: Previous research has identified similar prognostic factors in patients with musculoskeletal (MSK) conditions regardless of pain presentation, generating opportunities for management based on prognosis rather than specific pain presentati... Read More about Clinical course and prognostic factors across different musculoskeletal pain sites: A secondary analysis of individual patient data from randomised clinical trials..

The INCLUDE study: INtegrating and improving Care for patients with infLammatory rheUmatological DisordErs in the community; identifying multimorbidity: Protocol for a pilot randomized controlled trial. (2018)
Journal Article
Healey, E., Herron, D., Hider, S., Bucknall, M., Cooke, K., Finney, A., …Chew-Graham, C. (2018). The INCLUDE study: INtegrating and improving Care for patients with infLammatory rheUmatological DisordErs in the community; identifying multimorbidity: Protocol for a pilot randomized controlled trial. Journal of Comorbidity, 8(1), https://doi.org/10.1177/2235042X18792373

Background: Patients with inflammatory rheumatic conditions such as rheumatoid arthritis, polymyalgia rheumatica and ankylosing spondylitis are at increased risk of common comorbidities such as cardiovascular disease, osteoporosis and anxiety and dep... Read More about The INCLUDE study: INtegrating and improving Care for patients with infLammatory rheUmatological DisordErs in the community; identifying multimorbidity: Protocol for a pilot randomized controlled trial..

Effectiveness and costs of a vocational advice service to improve work outcomes in patients with musculoskeletal pain in primary care: a cluster randomised trial (SWAP trial ISRCTN 52269669). (2018)
Journal Article
Wynne-Jones, G., Artus, M., Bishop, A., Lawton, S., Lewis, M., Jowett, S., …Van Der Windt, D. (2018). Effectiveness and costs of a vocational advice service to improve work outcomes in patients with musculoskeletal pain in primary care: a cluster randomised trial (SWAP trial ISRCTN 52269669). PAIN, 159(1), 128-138. https://doi.org/10.1097/j.pain.0000000000001075

Musculoskeletal pain is a common cause of work absence and early intervention is advocated to prevent the adverse health and economic consequences of longer-term absence. This cluster randomised controlled trial investigated the effect of introducing... Read More about Effectiveness and costs of a vocational advice service to improve work outcomes in patients with musculoskeletal pain in primary care: a cluster randomised trial (SWAP trial ISRCTN 52269669)..

Multisite peripheral joint pain: a cross-sectional study of prevalence and impact on general health, quality of life, pain intensity and consultation behaviour (2017)
Journal Article
Finney, A., Dziedzic, K., Lewis, A., & Healey, E. (2017). Multisite peripheral joint pain: a cross-sectional study of prevalence and impact on general health, quality of life, pain intensity and consultation behaviour. BMC Musculoskeletal Disorders, 18, Article 535. https://doi.org/10.1186/s12891-017-1896-3

Background Research into musculoskeletal conditions often focusses on pain at single sites, such as the knee, yet several studies have previously reported the high prevalence of multiple sites of musculoskeletal pain. The most common form of musculo... Read More about Multisite peripheral joint pain: a cross-sectional study of prevalence and impact on general health, quality of life, pain intensity and consultation behaviour.

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