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The frequency of testing for glycated haemoglobin, HbA1c, is linked to the probability of achieving target levels in patients with suboptimally controlled diabetes mellitus. (2018)
Journal Article
Duff, C. J., Solis-Trapala, I., Driskell, O. J., Holland, D., Wright, H., Waldron, J. L., …Fryer, A. A. (2018). The frequency of testing for glycated haemoglobin, HbA1c, is linked to the probability of achieving target levels in patients with suboptimally controlled diabetes mellitus. Clinical Chemistry and Laboratory Medicine, https://doi.org/10.1515/cclm-2018-0503

Introduction: We previously showed, in patients with diabetes, that >50% of monitoring tests for glycated hemoglobin (HbA1c) are outside recommended intervals and that this is linked to diabetes control. Here, we examined the impact of tests/year on... Read More about The frequency of testing for glycated haemoglobin, HbA1c, is linked to the probability of achieving target levels in patients with suboptimally controlled diabetes mellitus..

Real-world practice level data analysis confirms link between variability within Blood Glucose Monitoring Strip (BGMS) and glycosylated haemoglobin (HbA1c) in Type 1 Diabetes. (2018)
Journal Article
Heald, A. H., Livingston, M., Fryer, A., Cortes, G., Anderson, S. G., Gadsby, R., …Stedman, M. (2018). Real-world practice level data analysis confirms link between variability within Blood Glucose Monitoring Strip (BGMS) and glycosylated haemoglobin (HbA1c) in Type 1 Diabetes. International Journal of Clinical Practice, 72, Article e13252. https://doi.org/10.1111/ijcp.13252

AIMS/HYPOTHESIS: Our aim was to quantify the impact of Blood Glucose Monitoring Strips variability (BGMSV) at GP practice level on the variability of reported glycated haemoglobin (HbA1cV) levels. METHODS: Overall GP Practice BGMSV and HbA1cV were ca... Read More about Real-world practice level data analysis confirms link between variability within Blood Glucose Monitoring Strip (BGMS) and glycosylated haemoglobin (HbA1c) in Type 1 Diabetes..

Gestational diabetes mellitus: are mothers being followed-up? A retrospective study (2018)
Presentation / Conference
Ward, R., Hanna, F. W., Shelley-Hitchen, A., Hodgson, E., Heald, A., Fryer, A. A., & Duff, C. J. (2018, June). Gestational diabetes mellitus: are mothers being followed-up? A retrospective study

Background Women with gestational diabetes (GDM) have an elevated risk of developing type 2 diabetes (T2DM). NICE Guidance recommends women who develop GDM are screened 6 weeks post-partum and annually thereafter. Aim To evaluate conformity to gui... Read More about Gestational diabetes mellitus: are mothers being followed-up? A retrospective study.

Long-term conditions and the National Diabetes Audit (2018)
Journal Article
Heald, A., Stedman, M., Farman, S., Fryer, A., Bailey, S., & Gadsby, R. (2018). Long-term conditions and the National Diabetes Audit. British Journal of General Practice (BJGP), 68(672), 320.2-320. https://doi.org/10.3399/bjgp18x697637

The management of long-term conditions1 in primary care has hit the headlines thanks to a report from the Academy of Medical Sciences,2 which highlighted the clustering of different physical and mental health conditions in a single patient, and estim... Read More about Long-term conditions and the National Diabetes Audit.

Photodynamic therapy corrects abnormal cancer-associated gene expression observed in actinic keratosis lesions and induces a remodeling effect in photodamaged skin (2018)
Journal Article
Joly, F., Deret, S., Gamboa, B., Menigot, C., Fogel, P., Mounier, C., …Voegel, J. J. (2018). Photodynamic therapy corrects abnormal cancer-associated gene expression observed in actinic keratosis lesions and induces a remodeling effect in photodamaged skin. Journal of Dermatological Science, 91(2), 206-218. https://doi.org/10.1016/j.jdermsci.2018.05.002

Background Actinic keratoses (AK) are proliferations of neoplastic keratinocytes in the epidermis resulting from cumulative exposure to ultraviolet radiation (UVR), which are liable to transform into squamous cell carcinoma (SCC). Organ Transplant R... Read More about Photodynamic therapy corrects abnormal cancer-associated gene expression observed in actinic keratosis lesions and induces a remodeling effect in photodamaged skin.

Reduction of unnecessary N-terminal pro-brain natriuretic peptide (NT-proBNP) tests: A further lesson in demand management (2018)
Journal Article
Livingston, M., Kalansooriya, A., Hartland, A., Fryer, A. A., Gupta, J., & Heald, A. H. (2018). Reduction of unnecessary N-terminal pro-brain natriuretic peptide (NT-proBNP) tests: A further lesson in demand management. International Journal of Clinical Practice, 72(4), Article ARTN e13071. https://doi.org/10.1111/ijcp.13071

The number of laboratory tests performed in the UK is steadily increasing (average 8-10% year-on-year increase).1 Funding for these tests is not increasing at the same rate. Hence, considerable interest has focused on managing the demand for patholog... Read More about Reduction of unnecessary N-terminal pro-brain natriuretic peptide (NT-proBNP) tests: A further lesson in demand management.

Real-world evidence confirms that increased blood glucose monitoring strip (BGMS) accuracy reduces glycated haemoglobin (HbA1c) variance (2018)
Presentation / Conference
HEALD, A., Livingston, M., Fryer, A., Cortes, M., Gadsby, R., Ollier, W., …Craig, J. (2018, March). Real-world evidence confirms that increased blood glucose monitoring strip (BGMS) accuracy reduces glycated haemoglobin (HbA1c) variance. Poster presented at Diabetes UK Professional Conference 2018, London ExCeL, London, UK

Aim: An in silico study has reported a link between less accurate BGMS and poorer glycaemic control, leading to significant differences in both hyper- and hypoglycaemic events. Our aim was to see if we could detect this effect of BGMS accuracy on gly... Read More about Real-world evidence confirms that increased blood glucose monitoring strip (BGMS) accuracy reduces glycated haemoglobin (HbA1c) variance.

Real-world data analysis of general practice prescribing (GPP) to highlight the growing challenges in application of appropriate medication for Type 2 diabetes (2018)
Presentation / Conference
HEALD, A., Livingston, M., Fryer, A., Cortes, M., Bien, Z., Gadsby, R., …Young, R. (2018, March). Real-world data analysis of general practice prescribing (GPP) to highlight the growing challenges in application of appropriate medication for Type 2 diabetes. Poster presented at Diabetes UK Professional Conference 2018, London ExCeL, London, UK

Objective: GP apply the wide variety of Type 2 diabetes medications at different rates. Our aim was to see if there are lessons to be learnt from analysing in detail these variations. Methods: England GPP and Quality Outcome Framework data over th... Read More about Real-world data analysis of general practice prescribing (GPP) to highlight the growing challenges in application of appropriate medication for Type 2 diabetes.

Maternal genome-wide DNA methylation profiling in gestational diabetes shows distinctive disease-associated changes relative to matched healthy pregnancies (2018)
Journal Article
Wu, P., Farrell, W., Haworth, K., Emes, R., Kitchen, M., Glossop, J., …Fryer, A. (2018). Maternal genome-wide DNA methylation profiling in gestational diabetes shows distinctive disease-associated changes relative to matched healthy pregnancies. Epigenetics, 122-128. https://doi.org/10.1080/15592294.2016.1166321

Several recent reports have described associations between gestational diabetes (GDM) and changes to the epigenomic landscape where the DNA samples were derived from either cord or placental sources. We employed genome-wide 450K array analysis to det... Read More about Maternal genome-wide DNA methylation profiling in gestational diabetes shows distinctive disease-associated changes relative to matched healthy pregnancies.

Identification of rare diseases by screening a population selected on the basis of routine pathology results—the PATHFINDER project: lysosomal acid lipase/cholesteryl ester storage disease substudy (2018)
Journal Article
Reynolds, T. M., Mewies, C., Hamilton, J., Wierzbicki, A. S., & Fryer, T. (2018). Identification of rare diseases by screening a population selected on the basis of routine pathology results—the PATHFINDER project: lysosomal acid lipase/cholesteryl ester storage disease substudy. Journal of Clinical Pathology, 71(7), 608-613. https://doi.org/10.1136/jclinpath-2017-204727

Aims Lysosomal acid lipase deficiency (LALD) is an autosomal recessive disorder of cholesterol ester storage associated with hepatic disease, cirrhosis and accelerated atherosclerosis. Its prevalence in the general population, patients with dyslipida... Read More about Identification of rare diseases by screening a population selected on the basis of routine pathology results—the PATHFINDER project: lysosomal acid lipase/cholesteryl ester storage disease substudy.

Management of incidental adrenal tumours. (2018)
Journal Article
Hanna, F., Issa, B., Sim, J., Keevil, B., & Fryer, A. (2018). Management of incidental adrenal tumours. BMJ, j5674 - ?. https://doi.org/10.1136/bmj.j5674

An incidental adrenal tumour, described in this article as an “adrenal incidentaloma,” is an adrenal mass discovered during imaging that was not performed for suspected adrenal disease. These are being detected more frequently in an ageing population... Read More about Management of incidental adrenal tumours..

HumanMethylation450K Array–Identified Biomarkers Predict Tumour Recurrence/Progression at Initial Diagnosis of High-risk Non-muscle Invasive Bladder Cancer (2018)
Journal Article
Kitchen, M. O., Bryan, R. T., Emes, R. D., Luscombe, C. J., Cheng, K., Zeegers, M. P., …Fryer, A. A. (2018). HumanMethylation450K Array–Identified Biomarkers Predict Tumour Recurrence/Progression at Initial Diagnosis of High-risk Non-muscle Invasive Bladder Cancer. Biomarkers in Cancer, 10, 1179299X1775192. https://doi.org/10.1177/1179299x17751920

Background: High-risk non-muscle invasive bladder cancer (HR-NMIBC) is a clinically unpredictable disease. Despite clinical risk estimation tools, many patients are undertreated with intra-vesical therapies alone, whereas others may be over-treated... Read More about HumanMethylation450K Array–Identified Biomarkers Predict Tumour Recurrence/Progression at Initial Diagnosis of High-risk Non-muscle Invasive Bladder Cancer.