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All Outputs (15)

Can we check serum lithium levels less often without compromising patient safety? (2021)
Journal Article
Heald, A. H., Holland, D., Stedman, M., Davies, M., Duff, C. J., Parfitt, C., Green, L., Scargill, J., Taylor, D., & Fryer, A. A. (2021). Can we check serum lithium levels less often without compromising patient safety?. BJPsych Open, e18 - ?. https://doi.org/10.1192/bjo.2021.1027

BACKGROUND: Lithium is viewed as the first-line long-term treatment for prevention of relapse in people with bipolar disorder.

AIMS: This study examined factors associated with the likelihood of maintaining serum lithium levels within the recomme... Read More about Can we check serum lithium levels less often without compromising patient safety?.

The experience of blood glucose monitoring in people with type 2 diabetes mellitus (T2DM) (2021)
Journal Article
Stedman, M., Rea, R., Duff, C. J., Livingston, M., McLoughlin, K., Wong, L., Brown, S., Grady, K., Gadsby, R., Gibson, J. M., Paisley, A., Fryer, A. A., & Heald, A. H. (2022). The experience of blood glucose monitoring in people with type 2 diabetes mellitus (T2DM). Endocrinology Diabetes & Metabolism, 5(2), https://doi.org/10.1002/edm2.302

BACKGROUND: Finger prick blood glucose (BG) monitoring remains a mainstay of management in people with type 2 diabetes (T2DM) who take sulphonylurea (SU) drugs or insulin. We recently examined patient experience of BG monitoring in people with type 1... Read More about The experience of blood glucose monitoring in people with type 2 diabetes mellitus (T2DM).

Adrenal Incidentaloma: Prevalence and Referral Patterns From Routine Practice in a Large UK University Teaching Hospital (2021)
Journal Article
Hanna, F. W. F., Hancock, S., George, C., Clark, A., Sim, J., Issa, B. G., Powner, G., Waldron, J., Duff, C. J., Lea, S. C., Golash, A., Sathiavageeswaran, M., Heald, A. H., & Fryer, A. A. (2022). Adrenal Incidentaloma: Prevalence and Referral Patterns From Routine Practice in a Large UK University Teaching Hospital. Journal of the Endocrine Society, 6(1), https://doi.org/10.1210/jendso/bvab180

Context: Adrenal incidentalomas (AIs) are increasingly being identified during unrelated imaging. Unlike AI clinical management, data on referral patterns in routine practice are lacking. Objective: This work aimed to identify factors associated with... Read More about Adrenal Incidentaloma: Prevalence and Referral Patterns From Routine Practice in a Large UK University Teaching Hospital.

The Variability In Glycosylated Haemoglobin (HbA1c) Testing Interval In People With Diabetes Is Linked To Long-Term Diabetes Control, Independent of HbA1c Test Interval (2021)
Journal Article
Heald, A., Holland, D., Stedman, M., Duff, C. J., Green, L., Scargill, J., Hanna, F. W., Wu, P., & Fryer, A. A. (in press). The Variability In Glycosylated Haemoglobin (HbA1c) Testing Interval In People With Diabetes Is Linked To Long-Term Diabetes Control, Independent of HbA1c Test Interval. Endocrine, https://doi.org/10.1530/endoabs.77.p64

Worldwide guidance advocates regular HbA1c testing for people with diabetes mellitus, usually 2-4/yr. We previously showed that HbA1c testing frequency is linked to outcome in terms of HbA1c control. Here we examine the effect of variability (standar... Read More about The Variability In Glycosylated Haemoglobin (HbA1c) Testing Interval In People With Diabetes Is Linked To Long-Term Diabetes Control, Independent of HbA1c Test Interval.

Assessment of the effect of the COVID-19 pandemic on UK HbA1c testing: implications for diabetes management and diagnosis. (2021)
Journal Article
Holland, D., Heald, A. H., Stedman, M., Hanna, F., Wu, P., Duff, C., Green, L., Robinson, S., Halsall, I., Gaskell, N., Pemberton, J., Bloor, C., & Fryer, A. A. (2021). Assessment of the effect of the COVID-19 pandemic on UK HbA1c testing: implications for diabetes management and diagnosis. Journal of Clinical Pathology, 76(3), https://doi.org/10.1136/jclinpath-2021-207776

AIMS: The COVID-19 pandemic, and the focus on mitigating its effects, has disrupted diabetes healthcare services worldwide. We aimed to quantify the effect of the pandemic on diabetes diagnosis/management, using glycated haemoglobin (HbA1c) as surrog... Read More about Assessment of the effect of the COVID-19 pandemic on UK HbA1c testing: implications for diabetes management and diagnosis..

The pattern of testing for glycosylated haemoglobin (HbA 1c ) in people with diabetes is linked to the long term trajectory of blood glucose control (2021)
Presentation / Conference
Fryer, A. . A., Holland, D., Duff, C. . J., & Heald, A. (2021, September). The pattern of testing for glycosylated haemoglobin (HbA 1c ) in people with diabetes is linked to the long term trajectory of blood glucose control

Background and aims: American Diabetes Association Guidelines (ADA) advocate testing “at least two times a year in patients who are meeting treatment goals” and “quarterly in patients who are not meeting glycaemic goals”. We previously described link... Read More about The pattern of testing for glycosylated haemoglobin (HbA 1c ) in people with diabetes is linked to the long term trajectory of blood glucose control.

What is the value of the 60‐minute cortisol measurement in the short synacthen test (SST)? Evidence for the defence (2021)
Journal Article
Michaelidou, M., Yadegarfar, G., Morris, L., Dolan, S., Robinson, A., Naseem, A., Livingston, M., Duff, C. J., Aamir, A. H., Fryer, A. A., Trainer, P., & Heald, A. H. (2021). What is the value of the 60‐minute cortisol measurement in the short synacthen test (SST)? Evidence for the defence. International Journal of Clinical Practice, 75(8), https://doi.org/10.1111/ijcp.14417

Novel HumanMethylatyion450 Analyses Reveal DNA Methylation Predictors of Future Diabetes Onset in Women With Polycystic Ovarian Syndrome (2021)
Journal Article
Kitchen, M., Manzur, A., Fryer, A., & Wu, P. (in press). Novel HumanMethylatyion450 Analyses Reveal DNA Methylation Predictors of Future Diabetes Onset in Women With Polycystic Ovarian Syndrome. Research Square, https://doi.org/10.21203/rs.3.rs-637359/v1

Aims.
Polycystic ovarian syndrome (PCOS) is a common endocrine disorder characterised by ovarian morphological, systemic biochemical, and menstrual changes. Women with PCOS are at significantly increased risk of raised fasting glucose, impaired gluc... Read More about Novel HumanMethylatyion450 Analyses Reveal DNA Methylation Predictors of Future Diabetes Onset in Women With Polycystic Ovarian Syndrome.

Inadequate post-partum screening for type 2 diabetes in women with previous gestation diabetes mellitus: a retrospective audit of practice over 17 years. (2021)
Journal Article
Ward, R. J., Fryer, A. A., Hanna, F. W., Spencer, N., Mahmood, M., Wu, P., Heald, A. H., & Duff, C. J. (2021). Inadequate post-partum screening for type 2 diabetes in women with previous gestation diabetes mellitus: a retrospective audit of practice over 17 years. International Journal of Clinical Practice, e14447 - ?. https://doi.org/10.1111/ijcp.14447

INTRODUCTION: Women with gestational diabetes (GDM) are at greatly increased risk of type 2 diabetes (T2DM). The UK guidance recommends screening for T2DM at around 6 weeks post-partum and annually thereafter. We evaluated conformity to this guidance... Read More about Inadequate post-partum screening for type 2 diabetes in women with previous gestation diabetes mellitus: a retrospective audit of practice over 17 years..

Recalibration of thinking about adrenocortical function assessment: how the 'random' cortisol relates to the short synacthen test results (2021)
Journal Article
Michaelidou, M., Yadegarfar, G., Morris, L., Dolan, S., Robinson, A., Naseem, A., Livingston, M., Duff, C. J., Trainer, P., Fryer, A. A., & Heald, A. H. (2021). Recalibration of thinking about adrenocortical function assessment: how the 'random' cortisol relates to the short synacthen test results. Cardiovascular Endocrinology & Metabolism, 10(2), 137 - 145. https://doi.org/10.1097/XCE.0000000000000250

Background The short synacthen test (SST) is the most commonly performed investigation to assess adrenal function. Appropriate criteria for when an SST is performed are subject to debate. We investigated how random serum cortisol levels relate to SST... Read More about Recalibration of thinking about adrenocortical function assessment: how the 'random' cortisol relates to the short synacthen test results.

Investigation of polycystic ovarian syndrome: variation in practice and impact on the speed of diagnosis (2021)
Journal Article
Karia, A. M., Duff, C. J., Heald, A. H., Britton, I., Fryer, A. A., & Wu, P. (2021). Investigation of polycystic ovarian syndrome: variation in practice and impact on the speed of diagnosis. Cardiovascular Endocrinology & Metabolism, 10(2), 120-124. https://doi.org/10.1097/xce.0000000000000245

Objective Accurate diagnosis of polycystic ovarian syndrome (PCOS) enables clinical interventions/cardiometabolic risk factor management. Diagnosis can take over 2 years and multiple clinician contacts. We examined patterns of PCOS-associated biochem... Read More about Investigation of polycystic ovarian syndrome: variation in practice and impact on the speed of diagnosis.

Serum lithium test requesting across three UK regions: an evaluation of adherence to monitoring guidelines (2021)
Journal Article
Parfitt, C., Duff, C. J., Scargill, J., Green, L., Holland, D., Heald, A. H., & Fryer, A. A. (2021). Serum lithium test requesting across three UK regions: an evaluation of adherence to monitoring guidelines. BMC Psychiatry, 21, Article 32. https://doi.org/10.1186/s12888-020-03023-y

BACKGROUND: Bipolar disorder is the fourth most common mental health condition, affecting ~?1% of UK adults. Lithium is an effective treatment for prevention of relapse and hospital admission, and is widely recommended as a first-line treatment. We p... Read More about Serum lithium test requesting across three UK regions: an evaluation of adherence to monitoring guidelines.