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Cost of hospital treatment of type 1 diabetes (T1DM) and type 2 diabetes (T2DM) compared to the non-diabetes population: a detailed economic evaluation (2020)
Journal Article
Stedman, M., Lunt, M., Davies, M., Livingston, M., Duff, C., Fryer, A., Anderson, S. G., Gadsby, R., Gibson, M., Rayman, G., & Heald, A. (2020). Cost of hospital treatment of type 1 diabetes (T1DM) and type 2 diabetes (T2DM) compared to the non-diabetes population: a detailed economic evaluation. BMJ Open, 10(5), https://doi.org/10.1136/bmjopen-2019-033231

OBJECTIVES: Other than age, diabetes is the largest contributor to overall healthcare costs and reduced life expectancy in Europe. This paper aims to more exactly quantify the net impact of diabetes on different aspects of healthcare provision in hos... Read More about Cost of hospital treatment of type 1 diabetes (T1DM) and type 2 diabetes (T2DM) compared to the non-diabetes population: a detailed economic evaluation.

Applying Parkes Grid Method to Evaluate Impact of Variation in Blood Glucose Monitoring (BGM) Strip Accuracy Performance in Type 1 Diabetes Highlights the Potential for Amplification of Imprecision With Less Accurate BGM Strips (2020)
Journal Article
Stedman, M., Rea, R., Duff, C. J., Livingston, M., Moreno, G., Gadsby, R., Lunt, H., Fryer, A. A., & Heald, A. H. (2021). Applying Parkes Grid Method to Evaluate Impact of Variation in Blood Glucose Monitoring (BGM) Strip Accuracy Performance in Type 1 Diabetes Highlights the Potential for Amplification of Imprecision With Less Accurate BGM Strips. Journal of Diabetes Science and Technology, 15(1), 76-81. https://doi.org/10.1177/1932296820905880

The National Health Service spends £170 million on blood glucose monitoring (BGM) strips each year and there are pressures to use cheaper less accurate strips. Technology is also being used to increase test frequency with less focus on accuracy.
Pre... Read More about Applying Parkes Grid Method to Evaluate Impact of Variation in Blood Glucose Monitoring (BGM) Strip Accuracy Performance in Type 1 Diabetes Highlights the Potential for Amplification of Imprecision With Less Accurate BGM Strips.

Screening for thyroid disease in patients with type 2 diabetes mellitus: An evaluation of current practice (2020)
Journal Article
Palit, T., Heald, A. H., Fryer, A. A., & Duff, C. J. (2020). Screening for thyroid disease in patients with type 2 diabetes mellitus: An evaluation of current practice. Annals of Clinical Biochemistry, 57(3), 242-245. https://doi.org/10.1177/0004563220910772

Background
United Kingdom national guidelines do not recommend routine testing for thyroid disease in people with type 2 diabetes mellitus (T2DM). However, some studies suggest an increased risk of thyroid dysfunction in T2DM. The aim of this study... Read More about Screening for thyroid disease in patients with type 2 diabetes mellitus: An evaluation of current practice.

Monomeric C-Reactive Protein in Serum With Markedly Elevated CRP Levels Shares Common Calcium-Dependent Ligand Binding Properties With an in vitro Dissociated Form of C-Reactive Protein (2020)
Journal Article
Williams, R. D., Moran, J. A., Fryer, A. A., Littlejohn, J. R., Williams, H. M., Greenhough, T. J., & Shrive, A. K. (2020). Monomeric C-Reactive Protein in Serum With Markedly Elevated CRP Levels Shares Common Calcium-Dependent Ligand Binding Properties With an in vitro Dissociated Form of C-Reactive Protein. Frontiers in Immunology, 11, Article ARTN 115. https://doi.org/10.3389/fimmu.2020.00115

A monomeric form of C-reactive protein (CRP) which precipitates with cell wall pneumococcal C polysaccharide (CWPS) and retains the ability to reversibly bind to its ligand phosphocholine has been produced through urea-induced dissociation at an opti... Read More about Monomeric C-Reactive Protein in Serum With Markedly Elevated CRP Levels Shares Common Calcium-Dependent Ligand Binding Properties With an in vitro Dissociated Form of C-Reactive Protein.

Adrenal lesions found incidentally: how to improve clinical and cost-effectiveness (2020)
Journal Article
Hanna, F., Issa, B., Lea, S., George, C., Golash, A., Firn, M., Ogunmekan, S., Maddock, E., Sim, J., Xydopoulos, G., Fordham, R., & Fryer, A. (2020). Adrenal lesions found incidentally: how to improve clinical and cost-effectiveness. BMJ Open Quality, 9(1), https://doi.org/10.1136/bmjoq-2018-000572

INTRODUCTION: Adrenal incidentalomas are lesions that are incidentally identified while scanning for other conditions. While most are benign and hormonally non-functional, around 20% are malignant and/or hormonally active, requiring prompt interventi... Read More about Adrenal lesions found incidentally: how to improve clinical and cost-effectiveness.

Screening for thyroid disease in patients with type 2 diabetes mellitus: An evaluation of current practice (2019)
Journal Article
Heald, A. H., Palit, T., Livingston, M., Duff, C., & Fryer, A. (2019). Screening for thyroid disease in patients with type 2 diabetes mellitus: An evaluation of current practice. International Journal of Clinical Practice, https://doi.org/10.1111/IJCP.13302

The above article from International Journal of Clinical Practice, published online on 7th December 2018 in Wiley Online Library (http://wileyonlinelibrary.com) has been withdrawn by agreement between the authors, the journal Editor in Chief, Leslie... Read More about Screening for thyroid disease in patients with type 2 diabetes mellitus: An evaluation of current practice.

Analysis of English general practice level data linking medication levels, service activity and demography to levels of glycaemic control being achieved in type 2 diabetes to improve clinical practice and patient outcomes. (2019)
Journal Article
Heald, A., Davies, M., Stedman, M., Livingston, M., Lunt, M., Fryer, A., & Gadsby, R. (2019). Analysis of English general practice level data linking medication levels, service activity and demography to levels of glycaemic control being achieved in type 2 diabetes to improve clinical practice and patient outcomes. BMJ Open, 9(9), e028278 - ?. https://doi.org/10.1136/bmjopen-2018-028278

OBJECTIVE: Evaluate relative clinical effectiveness of treatment options for type 2 diabetes mellitus (T2DM) using a statistical model of real-world evidence within UK general practitioner practices (GPP), to quantify the opportunities for diabetes c... Read More about Analysis of English general practice level data linking medication levels, service activity and demography to levels of glycaemic control being achieved in type 2 diabetes to improve clinical practice and patient outcomes..

SAT-371 Correlation of Midnight and Post Dexamethasone Salivary Cortisone and Cortisol with Post Dexamethasone Serum Cortisol Concentrations In Patients with Unilateral and Bilateral Adrenal Incidentalomas (2019)
Presentation / Conference Contribution
Naseem, A., Mason, O., Ensah, G., Keevil, B., Hanna, F., Fryer, A., & Issa, B. SAT-371 Correlation of Midnight and Post Dexamethasone Salivary Cortisone and Cortisol with Post Dexamethasone Serum Cortisol Concentrations In Patients with Unilateral and Bilateral Adrenal Incidentalomas. Presented at 101st Annual Meeting of the Endocrine Society; March 23 – 26th, 2019, New Orleans, Louisiana, USA

Correlation between midnight and post dexamethasone salivary cortisone and cortisol and post dexamethasone serum cortisol concentrations in patients with unilateral and bilateral adrenal incidentalomas Background: The commonest functional abnormality... Read More about SAT-371 Correlation of Midnight and Post Dexamethasone Salivary Cortisone and Cortisol with Post Dexamethasone Serum Cortisol Concentrations In Patients with Unilateral and Bilateral Adrenal Incidentalomas.

SAT-372 Correlation of Serum Dexamethasone and Cortisol Concentrations Post Dexamethasone 1 Mg in the Overnight Dexamethasone Suppression Test in Patients with Unilateral and Bilateral Adrenal Incidentalomas (2019)
Presentation / Conference Contribution
Naseem, A., Mason, O., Ensah, G., Keevil, B., Hanna, F. W. F., Fryer, A., & Issa, B. SAT-372 Correlation of Serum Dexamethasone and Cortisol Concentrations Post Dexamethasone 1 Mg in the Overnight Dexamethasone Suppression Test in Patients with Unilateral and Bilateral Adrenal Incidentalomas. Presented at ENDO 2019 Abstracts - 101st Annual Meeting of the Endocrine Society; March 23 – 26th, 2019, New Orleans, Louisiana, USA

Background: The most common functional abnormality in adrenal incidentalomas (AI) is autonomous cortisol secretion. Most guidelines recommend a 1 mg overnight dexamethasone suppression test (ONDST) as a screening test for this abnormality. There is s... Read More about SAT-372 Correlation of Serum Dexamethasone and Cortisol Concentrations Post Dexamethasone 1 Mg in the Overnight Dexamethasone Suppression Test in Patients with Unilateral and Bilateral Adrenal Incidentalomas.

SAT-374 Adrenal Incidentaloma Management: Development of a Cost-Effectiveness Tool (2019)
Presentation / Conference Contribution
Hanna, F. W. F., Issa, B., Lea, S., George, C., Golash, A., Firn, M., Sim, J., Xydopoulos, G., Fordham, R., & Fryer, A. SAT-374 Adrenal Incidentaloma Management: Development of a Cost-Effectiveness Tool. Presented at ENDO 2019 - 101st Annual Meeting of the Endocrine Society (23-26 March 2019), New Orleans, Louisiana, USA

More frequent lithium testing associates with lower hospital admission rate for bipolar disorder - what this tells us about GP practice engagement with this group (2019)
Presentation / Conference
Holland, D., Healy, A., Stedman, M., Duff, C., Fryer, A., Yung, A., & Bailey, S. (2019, April). More frequent lithium testing associates with lower hospital admission rate for bipolar disorder - what this tells us about GP practice engagement with this group. Presented at 27th European Congress of Psychiatry, Warsaw, Poland

Background and aims.– Lithium treatment is a cornerstone of bipolar
affective disorder management.
We determined how frequency of lithium level checks at GP (family) practice level relates to psychiatric admission rate for bipolar
affective disord... Read More about More frequent lithium testing associates with lower hospital admission rate for bipolar disorder - what this tells us about GP practice engagement with this group.

More frequent lithium testing in UK Primary Care associates with a lower hospital admission rate for bipolar disorder-What this can tell us about GP practice engagement with this group. (2019)
Journal Article
Holland, D., Duff, C. J., Farman, S., Fryer, A. A., Yung, A., Bailey, S., & Heald, A. H. (2019). More frequent lithium testing in UK Primary Care associates with a lower hospital admission rate for bipolar disorder-What this can tell us about GP practice engagement with this group. International Journal of Clinical Practice, 73(4), e13277. https://doi.org/10.1111/ijcp.13277

Practice based analysis of Type 2 diabetes shows that patients’ own perceptions of support within primary care as per GP Patient Survey (GPPS) are as important as medication and services in improving Target Glycaemic Control (TGC-%HbA1c results ≤58mmol/mol) and reducing high glycaemic risk (HGR-%HbA1c results >86mmol/mol) as reported in the National Diabetes Audit (NDA) (2019)
Presentation / Conference Contribution
Heald, A., Stedman, M., Fryer, A., Gadsby, R., Ollier, W., Bailey, S., Livingston, M., & Moreno, G. (2019, March). Practice based analysis of Type 2 diabetes shows that patients’ own perceptions of support within primary care as per GP Patient Survey (GPPS) are as important as medication and services in improving Target Glycaemic Control (TGC-%HbA1c results ≤58mmol/mol) and reducing high glycaemic risk (HGR-%HbA1c results >86mmol/mol) as reported in the National Diabetes Audit (NDA). Poster presented at Diabetes UK Professional Conference 2019, ACC Liverpool, Liverpool, UK

Aims: To evaluate the link between patients’ own perception of support within primary care and % patients in TGC and HGR groups, while allowing for local medication, services and demographics.

Method: National Diabetes Audit (NDA) 2016–17 publishe... Read More about Practice based analysis of Type 2 diabetes shows that patients’ own perceptions of support within primary care as per GP Patient Survey (GPPS) are as important as medication and services in improving Target Glycaemic Control (TGC-%HbA1c results ≤58mmol/mol) and reducing high glycaemic risk (HGR-%HbA1c results >86mmol/mol) as reported in the National Diabetes Audit (NDA).

Differences in activity from Hospital Episode Statistics (HES) for patients with Type 2 diabetes and patients without diabetes linked at GP Practice level (GPP) to levels of glycaemic control as measured by glycated haemoglobin (HbA1c) taken from National Diabetes Audit (NDA) allowing for age, social deprivation, gender and ethnicity of both populations (2019)
Presentation / Conference Contribution
Stedman, M., Heald, A., Davies, M., Fryer, A., Lunt, M., Livingstone, M., Gadsby, R., Moreno, G., & Andersen, S. (2019, March). Differences in activity from Hospital Episode Statistics (HES) for patients with Type 2 diabetes and patients without diabetes linked at GP Practice level (GPP) to levels of glycaemic control as measured by glycated haemoglobin (HbA1c) taken from National Diabetes Audit (NDA) allowing for age, social deprivation, gender and ethnicity of both populations. Paper presented at Diabetes UK Professional Conference 2019, ACC Liverpool, Liverpool, UK

Aims: To compare associated hospital activity between patients with Type 2 diabetes and patients without diabetes and consider the impact of differing levels of glycaemic control on this difference, allowing for variation in local demographics.

Me... Read More about Differences in activity from Hospital Episode Statistics (HES) for patients with Type 2 diabetes and patients without diabetes linked at GP Practice level (GPP) to levels of glycaemic control as measured by glycated haemoglobin (HbA1c) taken from National Diabetes Audit (NDA) allowing for age, social deprivation, gender and ethnicity of both populations.