Skip to main content

Research Repository

Advanced Search

All Outputs (31)

The value of an embedded qualitative study in a trial of a second antidepressant for people who had not responded to one antidepressant: understanding the perspectives of patients and general practitioners (2018)
Journal Article
Chew-Graham, C., Shepherd, T., Burroughs, H., Dixon, K., & Kessler, D. (2018). The value of an embedded qualitative study in a trial of a second antidepressant for people who had not responded to one antidepressant: understanding the perspectives of patients and general practitioners. BMC Family Practice, https://doi.org/10.1186/s12875-018-0877-4

BACKGROUND: Depression is the leading cause of disability worldwide, and is a major contributor to the overall global burden of disease. The number of prescriptions for antidepressants has risen dramatically in recent years yet up to 50% of patients... Read More about The value of an embedded qualitative study in a trial of a second antidepressant for people who had not responded to one antidepressant: understanding the perspectives of patients and general practitioners.

RCGP Research Paper of the Year 2017: of relevance to the General Practice Forward View? (2018)
Journal Article
Chew-Graham, C. (2018). RCGP Research Paper of the Year 2017: of relevance to the General Practice Forward View?. British Journal of General Practice, 68(676), 536-537. https://doi.org/10.3399/bjgp18X699641

The Research Paper of the Year (RPY), awarded by the Royal College of General Practitioners (RCGP), gives recognition to an individual or group of researchers who have undertaken and published an exceptional piece of research relating to general prac... Read More about RCGP Research Paper of the Year 2017: of relevance to the General Practice Forward View?.

How older adults self-manage distress - does the internet have a role? A qualitative study (2018)
Journal Article
Moult, A., Burroughs, H., Kingstone, T., & Chew-Graham, C. A. (2018). How older adults self-manage distress - does the internet have a role? A qualitative study. BMC Family Practice, 185 - ?. https://doi.org/10.1186/s12875-018-0874-7

BACKGROUND Anxiety and depression are common in older adults, but often under-recognised by GPs. Rather than perceiving themselves as suffering from anxiety or depression, older adults are more likely to self-identify as experiencing low mood, stres... Read More about How older adults self-manage distress - does the internet have a role? A qualitative study.

The Elicitation and Management of Multiple Health Concerns in GP Consultations (2018)
Journal Article
Chew-Graham. (2018). The Elicitation and Management of Multiple Health Concerns in GP Consultations. Patient Education and Counseling, https://doi.org/10.1016/j.pec.2018.11.009

Objective To describe the nature of patient concerns and to explore if, when and how they are addressed by GPs in the UK. Methods Detailed coding and descriptive analysis of 185 video recordings from the EPaC study (Elicitation of Patient Concer... Read More about The Elicitation and Management of Multiple Health Concerns in GP Consultations.

Combining mirtazapine with SSRIs or SNRIs for treatment-resistant depression: the MIR RCT. (2018)
Journal Article
Chew-Graham. (2018). Combining mirtazapine with SSRIs or SNRIs for treatment-resistant depression: the MIR RCT. Health Technology Assessment, 1 - 136. https://doi.org/10.3310/hta22630

BACKGROUND: Depression is usually managed in primary care and antidepressants are often the first-line treatment, but only half of those treated respond to a single antidepressant. OBJECTIVES: To investigate whether or not combining mirtazapine with... Read More about Combining mirtazapine with SSRIs or SNRIs for treatment-resistant depression: the MIR RCT..

Self-harm in a primary care cohort of older people: incidence, clinical management, and risk of suicide and other causes of death (2018)
Journal Article
Morgan, C., Webb, R. T., Carr, M. J., Kontopantelis, E., Chew-Graham, C. A., Kapur, N., & Ashcroft, D. M. (2018). Self-harm in a primary care cohort of older people: incidence, clinical management, and risk of suicide and other causes of death. The Lancet Psychiatry, 905-912. https://doi.org/10.1016/S2215-0366%2818%2930348-1

BACKGROUND: Self-harm is a major risk factor for suicide, with older adults (older than 65 years) having reportedly greater suicidal intent than any other age group. With the aging population rising and paucity of research focus in this age group, th... Read More about Self-harm in a primary care cohort of older people: incidence, clinical management, and risk of suicide and other causes of death.

Mirtazapine added to SSRIs or SNRIs for treatment resistant depression in primary care: phase III randomised placebo controlled trial (MIR) (2018)
Journal Article
Kessler, D. S., MacNeill, S. J., Tallon, D., Lewis, G., Peters, T. J., Hollingworth, W., …Wiles, N. J. (2018). Mirtazapine added to SSRIs or SNRIs for treatment resistant depression in primary care: phase III randomised placebo controlled trial (MIR). BMJ, k4218 - ?. https://doi.org/10.1136/bmj.k4218

OBJECTIVE: To investigate the effectiveness of combining mirtazapine with serotonin-noradrenaline reuptake inhibitor (SNRI) or selective serotonin reuptake inhibitor (SSRI) antidepressants for treatment resistant depression in primary care. DESIGN: T... Read More about Mirtazapine added to SSRIs or SNRIs for treatment resistant depression in primary care: phase III randomised placebo controlled trial (MIR).

MIRtazapine added to SSRIs or SNRIs for Treatment Resistant Depression in Primary Care: a placebo controlled randomised trial (MIR) (2018)
Journal Article
Chew-Graham. (2018). MIRtazapine added to SSRIs or SNRIs for Treatment Resistant Depression in Primary Care: a placebo controlled randomised trial (MIR). BMJ, https://doi.org/10.1136/bmj.k4218

Objective: To investigate the effectiveness of combining mirtazapine with Serotonin-Noradrenaline Reuptake Inhibitor (SNRI) or Selective Serotonin Reuptake Inhibitor (SSRI) antidepressants for patients in primary care who had not responded to an anti... Read More about MIRtazapine added to SSRIs or SNRIs for Treatment Resistant Depression in Primary Care: a placebo controlled randomised trial (MIR).

Association Between Physician Burnout and Patient Safety, Professionalism, and Patient Satisfaction: A Systematic Review and Meta-analysis. (2018)
Journal Article
Chew-Graham. (2018). Association Between Physician Burnout and Patient Safety, Professionalism, and Patient Satisfaction: A Systematic Review and Meta-analysis. JAMA Internal Medicine, 1317 - 1330. https://doi.org/10.1001/jamainternmed.2018.3713

Importance: Physician burnout has taken the form of an epidemic that may affect core domains of health care delivery, including patient safety, quality of care, and patient satisfaction. However, this evidence has not been systematically quantified.... Read More about Association Between Physician Burnout and Patient Safety, Professionalism, and Patient Satisfaction: A Systematic Review and Meta-analysis..

The associated features of multiple somatic symptom complexes (2018)
Journal Article
Chew-Graham. (2018). The associated features of multiple somatic symptom complexes. Journal of Psychosomatic Research, 1-8. https://doi.org/10.1016/j.jpsychores.2018.06.007

Abstract Objective To assess whether two or more functional somatic symptom complexes (SSCs) showed stronger association with psychosocial correlates than single or no SSC after adjustment for depression/anxiety and general medical disorders. Methods... Read More about The associated features of multiple somatic symptom complexes.

Attending away from the body predicts increased physical symptom reports at six months in primary care patients (2018)
Journal Article
Chew-Graham. (2018). Attending away from the body predicts increased physical symptom reports at six months in primary care patients. Journal of Psychosomatic Research, 81 - 88. https://doi.org/10.1016/j.jpsychores.2018.08.002

Objective High symptom reporting (HSR) and medically unexplained symptoms (MUS) are associated with considerable distress, disability, healthcare utilization and costs, but are poorly understood, and current treatments are of limited benefit. Most mo... Read More about Attending away from the body predicts increased physical symptom reports at six months in primary care patients.

Self-reported sleep duration and quality and cardiovascular disease and mortality: a dose-response meta-analysis (2018)
Journal Article
Chew-Graham, & Mamas. (2018). Self-reported sleep duration and quality and cardiovascular disease and mortality: a dose-response meta-analysis. Journal of the American Heart Association Cardiovascular and Cerebrovascular Disease, https://doi.org/10.1161/jaha.118.008552

Abstract Background: There is growing evidence that sleep duration and quality may be associated with cardiovascular harm and mortality. Methods and Results: We conducted a systematic review, meta-analysis and spline analysis of prospective cohort st... Read More about Self-reported sleep duration and quality and cardiovascular disease and mortality: a dose-response meta-analysis.

Long-term clinical and cost-effectiveness of collaborative care (versus usual care) for people with mental–physical multimorbidity: cluster-randomised trial (2018)
Journal Article
Chew-Graham, C. (2018). Long-term clinical and cost-effectiveness of collaborative care (versus usual care) for people with mental–physical multimorbidity: cluster-randomised trial. British Journal of Psychiatry, 456-463. https://doi.org/10.1192/bjp.2018.70

Background Collaborative care can support the treatment of depression in people with long-term conditions, but long-term benefits and costs are unknown. Aims To explore the long-term (24-month) effectiveness and cost-effectiveness of collaborati... Read More about Long-term clinical and cost-effectiveness of collaborative care (versus usual care) for people with mental–physical multimorbidity: cluster-randomised trial.

How should we implement collaborative care for older people with depression? A qualitative study using normalisation process theory within the CASPER plus trial (2018)
Journal Article
Chew-Graham. (2018). How should we implement collaborative care for older people with depression? A qualitative study using normalisation process theory within the CASPER plus trial. BMC Family Practice, 116 -?. https://doi.org/10.1186/s12875-018-0813-7

BACKGROUND: Depression in older people may have a prevalence as high as 20%, and is associated with physical co-morbidities, loss, and loneliness. It is associated with poorer health outcomes and reduced quality of life, and is under-diagnosed and un... Read More about How should we implement collaborative care for older people with depression? A qualitative study using normalisation process theory within the CASPER plus trial.

Hajj: what it means for general practice (2018)
Journal Article
Saad, A., Mughal, F., & Chew-Graham, C. (2018). Hajj: what it means for general practice. British Journal of General Practice (BJGP), https://doi.org/10.3399/bjgpopen18X101493

Annually, about 20 000 British Muslims journey to Saudi Arabia to undertake the Hajj, the greater Muslim pilgrimage.1 The National Travel Health Network and Centre advises intended pilgrims to see their GP 6 weeks prior to travel, to review their hea... Read More about Hajj: what it means for general practice.

Using electronic health records to quantify and stratify the severity of type 2 diabetes in primary care in England: rationale and cohort study design (2018)
Journal Article
Mamas, Chew-Graham, & Mallen. (2018). Using electronic health records to quantify and stratify the severity of type 2 diabetes in primary care in England: rationale and cohort study design. BMJ Open, https://doi.org/10.1136/bmjopen-2017-020926

Introduction: The increasing prevalence of type 2 diabetes (T2DM) presents a significant burden on affected individuals and health-care systems internationally. There is, however, no agreed validated measure to infer diabetes severity from electronic... Read More about Using electronic health records to quantify and stratify the severity of type 2 diabetes in primary care in England: rationale and cohort study design.

Long-term clinical and cost-effectiveness of collaborative care (vs. usual care): a cluster-randomised trial (2018)
Journal Article
Chew-Graham. (2018). Long-term clinical and cost-effectiveness of collaborative care (vs. usual care): a cluster-randomised trial. https://doi.org/10.1192/bjp.2018.70

Background Collaborative care can support the treatment of depression in people with long-term conditions, but long-term benefits and costs are unknown. Aims To explore the long-term (24-month) effectiveness and cost-effectiveness of collaborati... Read More about Long-term clinical and cost-effectiveness of collaborative care (vs. usual care): a cluster-randomised trial.

‘Treading water but drowning slowly’: what are GPs’ experiences of living and working with mental illness and distress in England? A qualitative study (2018)
Journal Article
Chew-Graham. (2018). ‘Treading water but drowning slowly’: what are GPs’ experiences of living and working with mental illness and distress in England? A qualitative study. BMJ Open, https://doi.org/10.1136/bmjopen-2017-018620

Objectives This paper provides an in-depth account of general practitioners’ (GPs) experiences of living and working with mental illness and distress, as part of a wider study reporting the barriers and facilitators to help-seeking for mental illnes... Read More about ‘Treading water but drowning slowly’: what are GPs’ experiences of living and working with mental illness and distress in England? A qualitative study.