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All Outputs (429)

Self-harm in a primary care cohort of older people: incidence, clinical management, and risk of suicide and other causes of death (2018)
Journal Article
Morgan, C., Webb, R. T., Carr, M. J., Kontopantelis, E., Chew-Graham, C. A., Kapur, N., & Ashcroft, D. M. (2018). Self-harm in a primary care cohort of older people: incidence, clinical management, and risk of suicide and other causes of death. The Lancet Psychiatry, 905-912. https://doi.org/10.1016/S2215-0366%2818%2930348-1

BACKGROUND: Self-harm is a major risk factor for suicide, with older adults (older than 65 years) having reportedly greater suicidal intent than any other age group. With the aging population rising and paucity of research focus in this age group, th... Read More about Self-harm in a primary care cohort of older people: incidence, clinical management, and risk of suicide and other causes of death.

MIRtazapine added to SSRIs or SNRIs for Treatment Resistant Depression in Primary Care: a placebo controlled randomised trial (MIR) (2018)
Journal Article
Chew-Graham. (2018). MIRtazapine added to SSRIs or SNRIs for Treatment Resistant Depression in Primary Care: a placebo controlled randomised trial (MIR). BMJ, https://doi.org/10.1136/bmj.k4218

Objective: To investigate the effectiveness of combining mirtazapine with Serotonin-Noradrenaline Reuptake Inhibitor (SNRI) or Selective Serotonin Reuptake Inhibitor (SSRI) antidepressants for patients in primary care who had not responded to an anti... Read More about MIRtazapine added to SSRIs or SNRIs for Treatment Resistant Depression in Primary Care: a placebo controlled randomised trial (MIR).

Mirtazapine added to SSRIs or SNRIs for treatment resistant depression in primary care: phase III randomised placebo controlled trial (MIR) (2018)
Journal Article
Kessler, D. S., MacNeill, S. J., Tallon, D., Lewis, G., Peters, T. J., Hollingworth, W., Round, J., Burns, A., Chew-Graham, C. A., Anderson, I. M., Shepherd, T., Campbell, J., Dickens, C. M., Carter, M., Jenkinson, C., Macleod, U., Gibson, H., Davies, S., & Wiles, N. J. (2018). Mirtazapine added to SSRIs or SNRIs for treatment resistant depression in primary care: phase III randomised placebo controlled trial (MIR). BMJ, k4218 - ?. https://doi.org/10.1136/bmj.k4218

OBJECTIVE: To investigate the effectiveness of combining mirtazapine with serotonin-noradrenaline reuptake inhibitor (SNRI) or selective serotonin reuptake inhibitor (SSRI) antidepressants for treatment resistant depression in primary care. DESIGN: T... Read More about Mirtazapine added to SSRIs or SNRIs for treatment resistant depression in primary care: phase III randomised placebo controlled trial (MIR).

Association Between Physician Burnout and Patient Safety, Professionalism, and Patient Satisfaction: A Systematic Review and Meta-analysis. (2018)
Journal Article
Chew-Graham. (2018). Association Between Physician Burnout and Patient Safety, Professionalism, and Patient Satisfaction: A Systematic Review and Meta-analysis. JAMA Internal Medicine, 1317 - 1330. https://doi.org/10.1001/jamainternmed.2018.3713

Importance: Physician burnout has taken the form of an epidemic that may affect core domains of health care delivery, including patient safety, quality of care, and patient satisfaction. However, this evidence has not been systematically quantified.... Read More about Association Between Physician Burnout and Patient Safety, Professionalism, and Patient Satisfaction: A Systematic Review and Meta-analysis..

The associated features of multiple somatic symptom complexes (2018)
Journal Article
Chew-Graham. (2018). The associated features of multiple somatic symptom complexes. Journal of Psychosomatic Research, 1-8. https://doi.org/10.1016/j.jpsychores.2018.06.007

Abstract Objective To assess whether two or more functional somatic symptom complexes (SSCs) showed stronger association with psychosocial correlates than single or no SSC after adjustment for depression/anxiety and general medical disorders. Methods... Read More about The associated features of multiple somatic symptom complexes.

Attending away from the body predicts increased physical symptom reports at six months in primary care patients (2018)
Journal Article
Chew-Graham. (2018). Attending away from the body predicts increased physical symptom reports at six months in primary care patients. Journal of Psychosomatic Research, 81 - 88. https://doi.org/10.1016/j.jpsychores.2018.08.002

Objective High symptom reporting (HSR) and medically unexplained symptoms (MUS) are associated with considerable distress, disability, healthcare utilization and costs, but are poorly understood, and current treatments are of limited benefit. Most mo... Read More about Attending away from the body predicts increased physical symptom reports at six months in primary care patients.

Self-reported sleep duration and quality and cardiovascular disease and mortality: a dose-response meta-analysis (2018)
Journal Article
Chew-Graham, & Mamas. (2018). Self-reported sleep duration and quality and cardiovascular disease and mortality: a dose-response meta-analysis. Journal of the American Heart Association Cardiovascular and Cerebrovascular Disease, https://doi.org/10.1161/jaha.118.008552

Abstract Background: There is growing evidence that sleep duration and quality may be associated with cardiovascular harm and mortality. Methods and Results: We conducted a systematic review, meta-analysis and spline analysis of prospective cohort st... Read More about Self-reported sleep duration and quality and cardiovascular disease and mortality: a dose-response meta-analysis.

Long-term clinical and cost-effectiveness of collaborative care (versus usual care) for people with mental–physical multimorbidity: cluster-randomised trial (2018)
Journal Article
Chew-Graham, C. (2018). Long-term clinical and cost-effectiveness of collaborative care (versus usual care) for people with mental–physical multimorbidity: cluster-randomised trial. British Journal of Psychiatry, 456-463. https://doi.org/10.1192/bjp.2018.70

Background
Collaborative care can support the treatment of depression in people with long-term conditions, but long-term benefits and costs are unknown.

Aims
To explore the long-term (24-month) effectiveness and cost-effectiveness of collaborati... Read More about Long-term clinical and cost-effectiveness of collaborative care (versus usual care) for people with mental–physical multimorbidity: cluster-randomised trial.

How should we implement collaborative care for older people with depression? A qualitative study using normalisation process theory within the CASPER plus trial (2018)
Journal Article
Chew-Graham. (2018). How should we implement collaborative care for older people with depression? A qualitative study using normalisation process theory within the CASPER plus trial. BMC Family Practice, 116 -?. https://doi.org/10.1186/s12875-018-0813-7

BACKGROUND: Depression in older people may have a prevalence as high as 20%, and is associated with physical co-morbidities, loss, and loneliness. It is associated with poorer health outcomes and reduced quality of life, and is under-diagnosed and un... Read More about How should we implement collaborative care for older people with depression? A qualitative study using normalisation process theory within the CASPER plus trial.

Hajj: what it means for general practice (2018)
Journal Article
Saad, A., Mughal, F., & Chew-Graham, C. (2018). Hajj: what it means for general practice. British Journal of General Practice (BJGP), https://doi.org/10.3399/bjgpopen18X101493

Annually, about 20 000 British Muslims journey to Saudi Arabia to undertake the Hajj, the greater Muslim pilgrimage.1 The National Travel Health Network and Centre advises intended pilgrims to see their GP 6 weeks prior to travel, to review their hea... Read More about Hajj: what it means for general practice.

Using electronic health records to quantify and stratify the severity of type 2 diabetes in primary care in England: rationale and cohort study design (2018)
Journal Article
Mamas, Chew-Graham, & Mallen. (2018). Using electronic health records to quantify and stratify the severity of type 2 diabetes in primary care in England: rationale and cohort study design. BMJ Open, https://doi.org/10.1136/bmjopen-2017-020926

Introduction: The increasing prevalence of type 2 diabetes (T2DM) presents a significant burden on affected individuals and health-care systems internationally. There is, however, no agreed validated measure to infer diabetes severity from electronic... Read More about Using electronic health records to quantify and stratify the severity of type 2 diabetes in primary care in England: rationale and cohort study design.

Long-term clinical and cost-effectiveness of collaborative care (vs. usual care): a cluster-randomised trial (2018)
Journal Article
Chew-Graham. (2018). Long-term clinical and cost-effectiveness of collaborative care (vs. usual care): a cluster-randomised trial. https://doi.org/10.1192/bjp.2018.70

Background
Collaborative care can support the treatment of depression in people with long-term conditions, but long-term benefits and costs are unknown.

Aims
To explore the long-term (24-month) effectiveness and cost-effectiveness of collaborati... Read More about Long-term clinical and cost-effectiveness of collaborative care (vs. usual care): a cluster-randomised trial.

‘Treading water but drowning slowly’: what are GPs’ experiences of living and working with mental illness and distress in England? A qualitative study (2018)
Journal Article
Chew-Graham. (2018). ‘Treading water but drowning slowly’: what are GPs’ experiences of living and working with mental illness and distress in England? A qualitative study. BMJ Open, https://doi.org/10.1136/bmjopen-2017-018620

Objectives
This paper provides an in-depth account of general practitioners’ (GPs) experiences of living and working with mental illness and distress, as part of a wider study reporting the barriers and facilitators to help-seeking for mental illnes... Read More about ‘Treading water but drowning slowly’: what are GPs’ experiences of living and working with mental illness and distress in England? A qualitative study.

Involving the public in health research in Latin America: making the case for mental health (2018)
Journal Article
Troya, M. . I., Bartlam, B., & Chew-Graham, C. A. (2018). Involving the public in health research in Latin America: making the case for mental health. Pan American Journal of Public Health / Revista Panamericana de Salud Pública, 1-6. https://doi.org/10.26633/rpsp.2018.45

Patient and Public Involvement and Engagement (PPIE) has been increasingly encouraged in health services and research over the last two decades. Particularly strong evidence has been presented with regard to the impact PPIE has in certain research ar... Read More about Involving the public in health research in Latin America: making the case for mental health.

Relationship of anxiety with joint pain and its management: A population survey (2018)
Journal Article
Barnett, L. A., Pritchard, M. G., Edwards, J. J., Afolabi, E. K., Jordan, K. P., Healey, E. L., Finney, A. G., Chew-Graham, C. A., Mallen, C. D., & Dziedzic, K. S. (2018). Relationship of anxiety with joint pain and its management: A population survey. Musculoskeletal Care, 16(3), 353-362. https://doi.org/10.1002/msc.1243

Objectives
The aims of the present study was to examine the associations between the severity of pain and anxiety in a community population reporting joint pain, and to investigate the management of joint pain in the presence of comorbid anxiety.... Read More about Relationship of anxiety with joint pain and its management: A population survey.

Preterm delivery and maternal cardiovascular disease future risk: A systematic review and meta-analysis (2018)
Presentation / Conference Contribution
Wu, P., Gulati, M., Kwok, C., Wong, C., Narain, A., O'Brien, S., Chew-Graham, C., Verma, G., Kadam, U., & Mamas, M. (2018, April). Preterm delivery and maternal cardiovascular disease future risk: A systematic review and meta-analysis. Poster presented at British Maternal & Fetal Medicine Society (BMFMS) 20th Annual Conference 2018, Brighton, UK

Objectives

We aimed to systematically evaluate and summarise the evidence on the relationship between preterm birth (<37 weeks of gestational age) and maternal cardiovascular diseases future risk.

Design

Systematic review and meta-analysis o...

Cost-Utility Analysis of Routine Anxiety and Depression Screening in Patients Consulting for Osteoarthritis: Results From a Clinical, Randomized Controlled Trial (2018)
Journal Article
Kigozi, J., Jowett, S., Nicholl, B. I., Lewis, M., Bartlam, B., Green, D., Belcher, J., Clarkson, K., Lingard, Z., Pope, C., Chew-Graham, C. A., Croft, P., Hay, E., Peat, G., & Mallen, C. D. (2018). Cost-Utility Analysis of Routine Anxiety and Depression Screening in Patients Consulting for Osteoarthritis: Results From a Clinical, Randomized Controlled Trial. Arthritis Care and Research, 70(12), 1787-1794. https://doi.org/10.1002/acr.23568

OBJECTIVE: To investigate the cost-effectiveness (cost-utility) of introducing general practitioner screening for anxiety and depression in patients consulting with osteoarthritis (OA). METHODS: A cluster-randomised trial-based economic evaluation to... Read More about Cost-Utility Analysis of Routine Anxiety and Depression Screening in Patients Consulting for Osteoarthritis: Results From a Clinical, Randomized Controlled Trial.

i049 The importance of identifying and managing co-morbid anxiety and depression in people with rheumatological conditions (2018)
Presentation / Conference Contribution
Chew-Graham, C. i049 The importance of identifying and managing co-morbid anxiety and depression in people with rheumatological conditions. Presented at British Society for Rheumatology Annual Conference 2018

Anxiety and depression are common mental disorders and major contributors to the overall global burden of disease. Depression is a risk factor for suicide. Where anxiety and depression are co-morbid with a long term physical condition, the morbidity... Read More about i049 The importance of identifying and managing co-morbid anxiety and depression in people with rheumatological conditions.

A randomised controlled trial, cost-effectiveness and process evaluation of the implementation of self-management for chronic gastrointestinal disorders in primary care, and linked projects on identification and risk assessment (2018)
Journal Article
Thompson, D. G., O’Brien, S., Kennedy, A., Rogers, A., Whorwell, P., Lovell, K., Richardson, G., Reeves, D., Bower, P., Chew-Graham, C., Harkness, E., & Beech, P. A randomised controlled trial, cost-effectiveness and process evaluation of the implementation of self-management for chronic gastrointestinal disorders in primary care, and linked projects on identification and risk assessment. Programme Grants for Applied Research, 6(1), 1-154. https://doi.org/10.3310/pgfar06010

Background
Chronic gastrointestinal disorders are major burdens in primary care. Although there is some evidence that enhancing self-management can improve outcomes, it is not known if such models of care can be implemented at scale in routine NHS s... Read More about A randomised controlled trial, cost-effectiveness and process evaluation of the implementation of self-management for chronic gastrointestinal disorders in primary care, and linked projects on identification and risk assessment.