The BH3 Mimetic Obatoclax Accumulates in Lysosomes and Causes Their Alkalinization.
(2016)
Journal Article
Stamelos, V. A., Fisher, N., Bamrah, H., Voisey, C., Price, J. C., Farrell, W. E., …Richardson, A. (in press). The BH3 Mimetic Obatoclax Accumulates in Lysosomes and Causes Their Alkalinization. PloS one, e0150696 - ?. https://doi.org/10.1371/journal.pone.0150696
Obatoclax belongs to a class of compounds known as BH3 mimetics which function as antagonists of Bcl-2 family apoptosis regulators. It has undergone extensive preclinical and clinical evaluation as a cancer therapeutic. Despite this, it is clear that... Read More about The BH3 Mimetic Obatoclax Accumulates in Lysosomes and Causes Their Alkalinization..