All Outputs (6)

Malaria parasites undergo a rapid and extensive metamorphosis after invasion of the host erythrocyte. (2025)
Journal Article
Fréville, A., Moreira-Leite, F., Roussel, C., Russell, M. R. G., Fricot, A., Carret, V., Sissoko, A., Hayes, M. J., Diallo, A. B., Kerkhoven, N. C., Ressurreição, M., Dokmak, S., Blackman, M. J., Collinson, L. M., Buffet, P. A., Vaughan, S., Ndour, P. A., & van Ooij, C. (2025). Malaria parasites undergo a rapid and extensive metamorphosis after invasion of the host erythrocyte. EMBO Reports, 1-29. https://doi.org/10.1038/s44319-025-00435-3

Within the human host, the symptoms of malaria are caused by the replication of malaria parasites within erythrocytes. Growth inside the erythrocyte exposes the parasites to the normal surveillance of erythrocytes by the host organism, in particular... Read More about Malaria parasites undergo a rapid and extensive metamorphosis after invasion of the host erythrocyte..

Structure–function analysis of nucleotide housekeeping protein HAM1 from human malaria parasite Plasmodium falciparum (2024)
Journal Article
Saha, D., Pramanik, A., Freville, A., Siddiqui, A. A., Pal, U., Banerjee, C., Nag, S., Debsharma, S., Pramanik, S., Mazumder, S., Maiti, N. C., Datta, S., van Ooij, C., & Bandyopadhyay, U. (2024). Structure–function analysis of nucleotide housekeeping protein HAM1 from human malaria parasite Plasmodium falciparum. The FEBS Journal, 291(19), 4349-4371. https://doi.org/10.1111/febs.17216

Non-canonical nucleotides, generated as oxidative metabolic by-products, significantly threaten the genome integrity of Plasmodium falciparum and thereby, their survival, owing to their mutagenic effects. PfHAM1, an evolutionarily conserved inosine/x... Read More about Structure–function analysis of nucleotide housekeeping protein HAM1 from human malaria parasite Plasmodium falciparum.

Identification of a non-exported Plasmepsin V substrate that functions in the parasitophorous vacuole of malaria parasites (2024)
Journal Article
Fréville, A., Ressurreição, M., & van Ooij, C. (2024). Identification of a non-exported Plasmepsin V substrate that functions in the parasitophorous vacuole of malaria parasites. mBio, 15(1), https://doi.org/10.1128/mbio.01223-23

Malaria parasites alter multiple properties of the host erythrocyte by exporting proteins into the host cell. Many exported proteins contain a five-amino acid motif called the Plasmodium export element (PEXEL) that is cleaved by the parasite protease... Read More about Identification of a non-exported Plasmepsin V substrate that functions in the parasitophorous vacuole of malaria parasites.

Timing of dense granule biogenesis in asexual malaria parasites (2023)
Journal Article
Vallintine, T., & van Ooij, C. (2023). Timing of dense granule biogenesis in asexual malaria parasites. Microbiology, 169(8), https://doi.org/10.1099/mic.0.001389

Malaria is an important infectious disease that continues to claim hundreds of thousands of lives annually. The disease is caused by infection of host erythrocytes by apicomplexan parasites of the genus Plasmodium. The parasite contains three differe... Read More about Timing of dense granule biogenesis in asexual malaria parasites.

Distribution of malaria parasite-derived phosphatidylcholine in the infected erythrocyte (2023)
Journal Article
Vallintine, T., & van Ooij, C. (2023). Distribution of malaria parasite-derived phosphatidylcholine in the infected erythrocyte. mSphere, 8(5), Article e00131-23. https://doi.org/10.1128/msphere.00131-23

Malaria parasites modify their host erythrocyte in multiple ways, leading to changes in the deformability, adhesiveness, and permeability of the host erythrocyte. Most of these changes are mediated by proteins exported from the parasite to the host e... Read More about Distribution of malaria parasite-derived phosphatidylcholine in the infected erythrocyte.

Timing of dense granule biogenesis in asexual malaria parasites (2023)
Preprint / Working Paper
Vallintine, T., & van Ooij, C. Timing of dense granule biogenesis in asexual malaria parasites

Malaria is an important infectious disease that continues to claim hundreds of thousands of lives annually. The disease is caused by infection of host erythrocytes by apicomplexan parasites of the genus Plasmodium. The parasite contains three differe... Read More about Timing of dense granule biogenesis in asexual malaria parasites.