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All Outputs (33)

Possible giant cell arteritis symptoms are common in newly diagnosed patients with Polymyalgia Rheumatica: results from an incident primary care PMR cohort (2017)
Journal Article
Masson, W., Muller, S., Whittle, R., Prior, J., Helliwell, T., Mallen, C., & Hider, S. (2017). Possible giant cell arteritis symptoms are common in newly diagnosed patients with Polymyalgia Rheumatica: results from an incident primary care PMR cohort. BMC Rheumatology, 1, Article 7. https://doi.org/10.1186/s41927-017-0007-2

Background: To examine the frequency of possible giant cell arteritis (GCA) symptoms (including headache, temporal/scalp tenderness, jaw claudication and visual symptoms) in newly diagnosed polymyalgia rheumatica (PMR) patients in UK primary care. Me... Read More about Possible giant cell arteritis symptoms are common in newly diagnosed patients with Polymyalgia Rheumatica: results from an incident primary care PMR cohort.

Applying quantitative bias analysis to estimate the plausible effects of selection bias in a cluster randomised controlled trial: secondary analysis of the Primary care Osteoarthritis Screening Trial (POST). (2017)
Journal Article
Barnett, L., Mallen, C., Lewis, A., & Peat, G. (2017). Applying quantitative bias analysis to estimate the plausible effects of selection bias in a cluster randomised controlled trial: secondary analysis of the Primary care Osteoarthritis Screening Trial (POST). Trials, 18, 585 - ?. https://doi.org/10.1186/s13063-017-2329-1

BACKGROUND: Selection bias is a concern when designing cluster randomised controlled trials (c-RCT). Despite addressing potential issues at the design stage, bias cannot always be eradicated from a trial design. The application of bias analysis prese... Read More about Applying quantitative bias analysis to estimate the plausible effects of selection bias in a cluster randomised controlled trial: secondary analysis of the Primary care Osteoarthritis Screening Trial (POST)..

Factors Influencing Allopurinol Initiation in Primary Care. (2017)
Journal Article
Roddy, Mallen, Clarson, Belcher, & Hider. (2017). Factors Influencing Allopurinol Initiation in Primary Care. Annals of Family Medicine, 15(6), 557 - 560. https://doi.org/10.1370/afm.213

Despite guidance on appropriate initiation, urate-lowering therapy is prescribed for only a minority of patients with gout. Electronic health records for 8,142 patients with gout were used to investigate the effect of age, sex, comorbidities, number... Read More about Factors Influencing Allopurinol Initiation in Primary Care..

The OMERACT Core Domain Set for Outcome Measures for Clinical Trials in Polymyalgia Rheumatica (2017)
Journal Article
Mackie, S., Neill, L., Harrison, E., Black, R., Kermani, T., Simon, L., …Twohig, H. (2017). The OMERACT Core Domain Set for Outcome Measures for Clinical Trials in Polymyalgia Rheumatica. Journal of Rheumatology, 1515-1521. https://doi.org/10.3899/jrheum.161109

OBJECTIVE To inform development of a core domain set for outcome measures for clinical trials in polymyalgia rheumatica (PMR), we conducted patient consultations, a systematic review, a Delphi study, and 2 qualitative studies. METHODS Domains i... Read More about The OMERACT Core Domain Set for Outcome Measures for Clinical Trials in Polymyalgia Rheumatica.

Feasibility randomised multicentre, double-blind, double-dummy controlled trial of anakinra, an interleukin-1 receptor antagonist versus intramuscular methylprednisolone for acute gout attacks in patients with chronic kidney disease (ASGARD): protocol st… (2017)
Journal Article
Mallen, & Roddy. (2017). Feasibility randomised multicentre, double-blind, double-dummy controlled trial of anakinra, an interleukin-1 receptor antagonist versus intramuscular methylprednisolone for acute gout attacks in patients with chronic kidney disease (ASGARD): protocol st…. BMJ Open, https://doi.org/10.1136/bmjopen-2017-017121

Introduction Acute gout occurs in people with chronic kidney disease, who are commonly older people with comorbidities such as hypertension, heart disease and diabetes. Potentially harmful treatments are administered to these vulnerable patients due... Read More about Feasibility randomised multicentre, double-blind, double-dummy controlled trial of anakinra, an interleukin-1 receptor antagonist versus intramuscular methylprednisolone for acute gout attacks in patients with chronic kidney disease (ASGARD): protocol st….

What is the impact of giant cell arteritis on patients’ lives? A UK qualitative study (2017)
Journal Article
Liddle, J., Bartlam, R., Mallen, C. D., Mackie, S. L., Prior, J. A., Helliwell, T., & Richardson, J. C. (2017). What is the impact of giant cell arteritis on patients’ lives? A UK qualitative study. BMJ Open, 7(8), e017073 -?. https://doi.org/10.1136/bmjopen-2017-017073

OBJECTIVES: Clinical management of giant cell arteritis (GCA) involves balancing the risks and burdens arising from the disease with those arising from treatment, but there is little research on the nature of those burdens. We aimed to explore the im... Read More about What is the impact of giant cell arteritis on patients’ lives? A UK qualitative study.

The British Society for Rheumatology Guideline for the Management of Gout (2017)
Journal Article
Mallen, C., & Roddy, E. (2017). The British Society for Rheumatology Guideline for the Management of Gout. Rheumatology, 56(7), E1-E20. https://doi.org/10.1093/rheumatology/kex156

OBJECTIVES: We previously found large variations in general practitioner (GP) hypertension treatment probability in oldest-old (>80 years) between countries. We wanted to explore whether differences in country-specific cardiovascular disease (CVD) bu... Read More about The British Society for Rheumatology Guideline for the Management of Gout.

Assessment of the face validity. feasibility and utility of a patient-completed questionnaire for polymyalgia rheumatica: a postal survey using the QQ-10 questionnaire (2017)
Journal Article
Twohig, H., Jones, G., Mackie, S., Mallen, C., & Mitchell, C. (2017). Assessment of the face validity. feasibility and utility of a patient-completed questionnaire for polymyalgia rheumatica: a postal survey using the QQ-10 questionnaire. Pilot and Feasibility Studies, https://doi.org/10.1186/s40814-017-0150-y

Background The development of a patient-reported outcome measure (PROM) for polymyalgia rheumatica (PMR), a condition that causes pain, stiffness and disability, is necessary as there is no current validated disease-specific measure. Initial literat... Read More about Assessment of the face validity. feasibility and utility of a patient-completed questionnaire for polymyalgia rheumatica: a postal survey using the QQ-10 questionnaire.

Diagnostic delay for giant cell arteritis – a systematic review and meta-analysis (2017)
Journal Article
Prior, J. A., Ranjbar, H., Belcher, J., Mackie, S. L., Helliwell, T., Liddle, J., & Mallen, C. D. (2017). Diagnostic delay for giant cell arteritis – a systematic review and meta-analysis. BMC Medicine, 15, Article 120. https://doi.org/10.1186/s12916-017-0871-z

BACKGROUND: Giant cell arteritis (GCA), if untreated, can lead to blindness and stroke. The study's objectives were to (1) determine a new evidence-based benchmark of the extent of diagnostic delay for GCA and (2) examine the role of GCA-specific cha... Read More about Diagnostic delay for giant cell arteritis – a systematic review and meta-analysis.

Association between characteristics of pain and stiffness and the functional status of patients with incident polymyalgia rheumatica from primary care (2017)
Journal Article
Cawley, A., Prior, J., Muller, S., Helliwell, T., Hider, S., Dasgupta, B., …Mallen, C. (2017). Association between characteristics of pain and stiffness and the functional status of patients with incident polymyalgia rheumatica from primary care. Clinical Rheumatology, 37(6), 1639-1644. https://doi.org/10.1007/s10067-017-3730-6

This paper aims to examine the relationship between different characteristics of pain and stiffness and the functional status of patients with newly diagnosed polymyalgia rheumatica (PMR). Baseline analysis of an inception cohort study was conducted.... Read More about Association between characteristics of pain and stiffness and the functional status of patients with incident polymyalgia rheumatica from primary care.

Integrating case finding and initial management for osteoarthritis, anxiety and depression into routine primary care nurse-led long-term condition reviews: results from the enhance pilot trial (2017)
Journal Article
Jinks, C., Nicholls, E., Liddle, J., Healey, E., Evans, A., Chew-Graham, C., …Team, E. (2017). Integrating case finding and initial management for osteoarthritis, anxiety and depression into routine primary care nurse-led long-term condition reviews: results from the enhance pilot trial. Annals of the Rheumatic Diseases, 76(S2), 1433-1433. https://doi.org/10.1136/annrheumdis-2017-eular.2473

Background Co-morbid osteoarthritis (OA), anxiety and depression are undermanaged in primary care yet have significant impact on pain, disability and outcomes of other long-term conditions (LTCs). Objectives To test the feasibility and acceptabili... Read More about Integrating case finding and initial management for osteoarthritis, anxiety and depression into routine primary care nurse-led long-term condition reviews: results from the enhance pilot trial.

The pathway to consultation for rheumatoid arthritis: exploring anticipated actions between the onset of symptoms and face-to-face encounter with a healthcare professional. (2017)
Journal Article
Mallen. (2017). The pathway to consultation for rheumatoid arthritis: exploring anticipated actions between the onset of symptoms and face-to-face encounter with a healthcare professional. BMC Musculoskeletal Disorders, 258 -?. https://doi.org/10.1186/s12891-017-1619-9

BACKGROUND: When people first experience symptoms of rheumatoid arthritis (RA) they often delay seeking medical attention resulting in delayed diagnosis and treatment. This research assesses behaviours people might engage in prior to, or instead of,... Read More about The pathway to consultation for rheumatoid arthritis: exploring anticipated actions between the onset of symptoms and face-to-face encounter with a healthcare professional..

Gout and subsequent erectile dysfunction: a population-based cohort study from England (2017)
Journal Article
Abdul Sultan, A., Mallen, C., Hayward, R., Muller, S., Whittle, R., Hotston, M., & Roddy, E. (2017). Gout and subsequent erectile dysfunction: a population-based cohort study from England. Arthritis Research and Therapy, 19, Article 123. https://doi.org/10.1186/s13075-017-1322-0

BACKGROUND: An association has been suggested between gout and erectile dysfunction (ED), however studies quantifying the risk of ED amongst gout patients are lacking. We aimed to precisely determine the population-level absolute and relative rate of... Read More about Gout and subsequent erectile dysfunction: a population-based cohort study from England.

Improving management of gout in primary care: a new UK management guideline. (2017)
Journal Article
Mallen, & Roddy. (2017). Improving management of gout in primary care: a new UK management guideline. British Journal of General Practice (BJGP), 284 - 285. https://doi.org/10.3399/bjgp17X691313

Gout is the most prevalent inflammatory arthritis, affecting 2.5% of adults in the UK.1 Despite its prevalence and the availability of potentially ‘curative’ urate-lowering therapies (ULT) such as allopurinol, gout remains undertreated in both primar... Read More about Improving management of gout in primary care: a new UK management guideline..