All Outputs (29)

The Relationship Between Obesity and Patient-Reported Outcome Measures in People with Polymyalgia Rheumatica (2024)
Journal Article
Scott, I., Bajpai, R., Hider, S., Helliwell, T., Mallen, C., & Muller, S. (in press). The Relationship Between Obesity and Patient-Reported Outcome Measures in People with Polymyalgia Rheumatica. Rheumatology Advances in Practice, Article rkae081. https://doi.org/10.1093/rap/rkae081

Objective To examine the association between obesity and patient-reported outcomes measures (PROMs) in a primary care-based cohort of people with polymyalgia rheumatica (PMR). Methods The PMR Cohort Study recruited people with incident PMR from... Read More about The Relationship Between Obesity and Patient-Reported Outcome Measures in People with Polymyalgia Rheumatica.

Exploring practice and perspectives on shared decision-making about osteoporosis medicines in Fracture Liaison Services: the iFraP development qualitative study (2024)
Journal Article
Bullock, L., Manning, F., Hawarden, A., Fleming, J., Leyland, S., Clark, E. M., …Paskins, Z. (in press). Exploring practice and perspectives on shared decision-making about osteoporosis medicines in Fracture Liaison Services: the iFraP development qualitative study. Archives of Osteoporosis, 19(1), Article 50. https://doi.org/10.1007/s11657-024-01410-6

Summary Interviews and focus groups with patients, FLS clinicians, and GPs identified challenges relating to clinical and shared decision-making about bone health and osteoporosis medicines. Findings will inform the development of the multicomponent... Read More about Exploring practice and perspectives on shared decision-making about osteoporosis medicines in Fracture Liaison Services: the iFraP development qualitative study.

Uptake, safety and effectiveness of inactivated influenza vaccine in inflammatory bowel disease: a UK-wide study (2024)
Journal Article
Nakafero, G., Grainge, M. J., Card, T., Mallen, C. D., Nguyen Van-Tam, J. S., & Abhishek, A. (2024). Uptake, safety and effectiveness of inactivated influenza vaccine in inflammatory bowel disease: a UK-wide study. BMJ Open Gastroenterology, 11(1), Article e001370. https://doi.org/10.1136/bmjgast-2024-001370

Objective: To investigate (1) the UK-wide inactivated influenza vaccine (IIV) uptake in adults with inflammatory bowel disease (IBD), (2) the association between vaccination against influenza and IBD flare and (3) the effectiveness of IIV in preventi... Read More about Uptake, safety and effectiveness of inactivated influenza vaccine in inflammatory bowel disease: a UK-wide study.

2023 EULAR classification criteria for hand osteoarthritis. (2024)
Journal Article
Haugen, I. K., Felson, D. T., Abhishek, A., Berenbaum, F., Bierma-Zeinstra, S., Dziedzic, K. S., …Kloppenburg, M. (in press). 2023 EULAR classification criteria for hand osteoarthritis. Annals of the Rheumatic Diseases, https://doi.org/10.1136/ard-2023-225073

The objective of this study is to develop classification criteria for overall hand osteoarthritis (OA), interphalangeal OA and thumb base OA based on self-reported data and radiographic features. The classification criteria sets were developed in thr... Read More about 2023 EULAR classification criteria for hand osteoarthritis..

Long-term outcomes of COVID-19 infection in children and young people: a systematic review and meta-analysis [version 1; peer review: awaiting peer review] (2024)
Journal Article
Twohig, H., Bajpai, R., Corp, N., Faux-Nightingale, A., Mallen, C., Robinson, T., …Burton, C. (2024). Long-term outcomes of COVID-19 infection in children and young people: a systematic review and meta-analysis [version 1; peer review: awaiting peer review]. NIHR Open Research, 4(22), https://doi.org/10.3310/nihropenres.13549.1

Background Children and young people (CYP) may experience prolonged symptoms following COVID-19, commonly termed ‘Long-COVID’. The characteristics of Long-COVID in CYP are unclear, as are the sequalae of acute COVID-19. We aimed to systematically sy... Read More about Long-term outcomes of COVID-19 infection in children and young people: a systematic review and meta-analysis [version 1; peer review: awaiting peer review].

Impact of research activity on performance of general practices: a qualitative study. (2024)
Journal Article
Kenning, C., Usher-Smith, J. A., Jamison, J., Jones, J., Boaz, A., Little, P., …Park, S. (in press). Impact of research activity on performance of general practices: a qualitative study. British Journal of General Practice Open (BJGP Open), Article BJGPO.2024.0073. https://doi.org/10.3399/BJGPO.2024.0073

There is evidence that engaging in research is directly associated with better performance. If this relationship is to be strengthened, it is necessary to understand the mechanisms which might underlie that relationship. To explore the perspectives o... Read More about Impact of research activity on performance of general practices: a qualitative study..

Prognostic factors for colchicine prophylaxis-related adverse events when initiating allopurinol for gout: retrospective cohort study (2024)
Journal Article
Bajpai, R., Partington, R., Muller, S., Forrester, H., Mallen, C. D., Clarson, L., …Roddy, E. (2024). Prognostic factors for colchicine prophylaxis-related adverse events when initiating allopurinol for gout: retrospective cohort study. Rheumatology, Article keae229. https://doi.org/10.1093/rheumatology/keae229

Objectives Colchicine is commonly used to prevent flares when starting urate-lowering therapy for gout. Patients with gout are frequently concurrently prescribed other medications (such as statins) that may interact with colchicine, increasing the r... Read More about Prognostic factors for colchicine prophylaxis-related adverse events when initiating allopurinol for gout: retrospective cohort study.

Designing a primary care pharmacist-led review for people treated with opioids for persistent pain: a multi-method qualitative study (2024)
Journal Article
Woodcock, C., Cornwall, N., Dikomitis, L., Harrisson, S. A., White, S., Helliwell, T., …Jinks, C. (2024). Designing a primary care pharmacist-led review for people treated with opioids for persistent pain: a multi-method qualitative study. British Journal of General Practice Open (BJGP Open), Article BJGPO.2023.0221. https://doi.org/10.3399/BJGPO.2023.0221

Background Opioids are frequently prescribed for persistent non-cancer pain despite limited evidence of long-term effectiveness and risk of harm. Evidence-based interventions to address inappropriate opioid prescribing are lacking. Aim To explore... Read More about Designing a primary care pharmacist-led review for people treated with opioids for persistent pain: a multi-method qualitative study.

Hearing the patient voice for persistent pain intervention development: Recommendations for using a bespoke online discussion forum for qualitative data collection (2024)
Journal Article
Woodcock, C., Cornwall, N., Harrisson, S., Jinks, C., Buttery, A., Ashworth, J., …Dikomitis, L. (in press). Hearing the patient voice for persistent pain intervention development: Recommendations for using a bespoke online discussion forum for qualitative data collection. British Journal of Pain,

We discuss a bespoke online discussion forum as an innovative method for qualitative data collection in the context of developing an intervention for patients prescribed opioids for persistent pain. We discuss the following key areas: planning and de... Read More about Hearing the patient voice for persistent pain intervention development: Recommendations for using a bespoke online discussion forum for qualitative data collection.

Identifying carers in general practice (STATUS QUO): a multicentre, cross-sectional study in England (2024)
Journal Article
Lawton, S., Mallen, C., Hussain, Z., Bajpai, R., Muller, S., Holmstrom, C., …Helliwell, T. (2024). Identifying carers in general practice (STATUS QUO): a multicentre, cross-sectional study in England. BMJ Open, 14(4), Article e083816. https://doi.org/10.1136/bmjopen-2023-083816

Objectives: To determine General Practice (GP) recording of carer status and the number of patients self-identifying as carers, while self-completing an automated check-in screen prior to a GP consultation. Design: A descriptive cross-sectional st... Read More about Identifying carers in general practice (STATUS QUO): a multicentre, cross-sectional study in England.

Risk of adverse outcomes during gabapentinoid therapy and factors associated with increased risk in UK primary care using the clinical practice research datalink: a cohort study. (2024)
Journal Article
Muller, S., Bailey, J., Bajpai, R., Helliwell, T., Harrisson, S. A., Whittle, R., …Ashworth, J. (in press). Risk of adverse outcomes during gabapentinoid therapy and factors associated with increased risk in UK primary care using the clinical practice research datalink: a cohort study. PAIN, https://doi.org/10.1097/j.pain.0000000000003239

Growing evidence from pharmacovigilance data and postmortem toxicology reports highlights the misuse potential of gabapentinoids. This study aimed to investigate the risk of serious adverse outcomes (drug misuse, overdose, major trauma), and their ri... Read More about Risk of adverse outcomes during gabapentinoid therapy and factors associated with increased risk in UK primary care using the clinical practice research datalink: a cohort study..

Protocol for a trial-based economic evaluation analysis of a complex digital health intervention including a computerised decision support tool: the iFraP intervention (2024)
Journal Article
Siciliano, M., Bathers, S., Bentley, I., Bullock, L., Cherrington, A., Clark, E., …Iglesias-Urrutia, C. (in press). Protocol for a trial-based economic evaluation analysis of a complex digital health intervention including a computerised decision support tool: the iFraP intervention. NIHR Open Research, 4(15), https://doi.org/10.3310/nihropenres.13575.1

Background Digital health interventions (DHI) are associated with significant promise. In recent years, the need to assess the value of these healthcare technologies has motivated a debate regarding the suitability of existing economic evaluation me... Read More about Protocol for a trial-based economic evaluation analysis of a complex digital health intervention including a computerised decision support tool: the iFraP intervention.

A person-centred consultation intervention to improve shared decision-making about, and uptake of, osteoporosis medicines (iFraP): a pragmatic, parallel-group, individual randomised controlled trial protocol (2024)
Journal Article
Bullock, L., Nicholls, E., Cherrington, A., Butler-Walley, S., Clark, E. M., Fleming, J., …Paskins, Z. (in press). A person-centred consultation intervention to improve shared decision-making about, and uptake of, osteoporosis medicines (iFraP): a pragmatic, parallel-group, individual randomised controlled trial protocol. NIHR Open Research, 4(14), https://doi.org/10.3310/nihropenres.13571.1

Background Good quality shared decision-making (SDM) conversations involve people with, or at risk of osteoporosis and clinicians collaborating to decide, where appropriate, which evidence-based medicines best fit the person’s life, beliefs, and val... Read More about A person-centred consultation intervention to improve shared decision-making about, and uptake of, osteoporosis medicines (iFraP): a pragmatic, parallel-group, individual randomised controlled trial protocol.

The SelfSTarT intervention for low back pain patients presenting to first contact physiotherapists: A mixed methods service evaluation (2024)
Journal Article
Stevenson, K., Hadley‐Barrows, T., Evans, N., Campbell, L., Southam, J., Chudyk, A., …Hill, J. C. (2024). The SelfSTarT intervention for low back pain patients presenting to first contact physiotherapists: A mixed methods service evaluation. Musculoskeletal Care, 22(1), Article e1876. https://doi.org/10.1002/msc.1876

Introduction Globally, back pain is the leading cause of years of disability. In the United Kingdom, over 20 million people live with musculoskeletal (MSK) pain, with low back pain being one of the most common causes. National strategies promote sel... Read More about The SelfSTarT intervention for low back pain patients presenting to first contact physiotherapists: A mixed methods service evaluation.

Patient and health professional views on risk-stratified monitoring of immune-suppressing treatment in adults with inflammatory diseases (2024)
Journal Article
Fuller, A., Hancox, J., Williams, H. C., Card, T., Taal, M. W., Aithal, G. P., …Abhishek, A. (2024). Patient and health professional views on risk-stratified monitoring of immune-suppressing treatment in adults with inflammatory diseases. Rheumatology, Article keae175. https://doi.org/10.1093/rheumatology/keae175

To explore the acceptability of an individualised risk-stratified approach to monitoring for target-organ toxicity in adult patients with immune-mediated inflammatory diseases established on immune-suppressing treatment(s). Adults (≥18 years) taking... Read More about Patient and health professional views on risk-stratified monitoring of immune-suppressing treatment in adults with inflammatory diseases.

Barriers and facilitators in diagnosing axial spondyloarthritis: a qualitative study (2024)
Journal Article
Hay, C. A., Packham, J., Prior, J. A., Mallen, C. D., & Ryan, S. (2024). Barriers and facilitators in diagnosing axial spondyloarthritis: a qualitative study. Rheumatology International, 44, 863–884. https://doi.org/10.1007/s00296-024-05554-z

Diagnosis of axial spondyloarthritis (axSpA) is frequently delayed for years after symptom onset. However, little is known about patient and healthcare professional (HCP) perspectives on barriers and facilitators in axSpA diagnosis. This study explor... Read More about Barriers and facilitators in diagnosing axial spondyloarthritis: a qualitative study.

Risk-stratified monitoring for sulfasalazine toxicity: prognostic model development and validation (2024)
Journal Article
Abhishek, A., Grainge, M., Card, T., Williams, H. C., Taal, M. W., Aithal, G. P., …Riley, R. (2024). Risk-stratified monitoring for sulfasalazine toxicity: prognostic model development and validation. RMD Open, 10(1), Article e003980. https://doi.org/10.1136/rmdopen-2023-003980

Background: Sulfasalazine-induced cytopenia, nephrotoxicity and hepatotoxicity is uncommon during long-term treatment. Some guidelines recommend 3 monthly monitoring blood tests indefinitely during long-term treatment while others recommend stopping... Read More about Risk-stratified monitoring for sulfasalazine toxicity: prognostic model development and validation.

Health Literacy and Gout Characteristics in a Primary Care Cohort (2024)
Journal Article
Watson, L., Protheroe, J., Mallen, C., Muller, S., & Roddy, E. (2024). Health Literacy and Gout Characteristics in a Primary Care Cohort. Rheumatology Advances in Practice, 8(2), Article rkae034. https://doi.org/10.1093/rap/rkae034

Objectives To examine the cross-sectional association between health literacy and gout characteristics. Methods In a primary care cohort of adults living with gout, the prevalence of poor health literacy was defined using the Single-Item Literac... Read More about Health Literacy and Gout Characteristics in a Primary Care Cohort.

“We have to change our mindsets”: a qualitative study of barriers and facilitators in research collaboration across integrated care system organisations (2024)
Journal Article
Gidlow, C. J., Sams, L., Buckless, K., Ellis, N. J., Duffy, H. C., Lambley-Burke, R., …Mallen, C. D. (2024). “We have to change our mindsets”: a qualitative study of barriers and facilitators in research collaboration across integrated care system organisations. BMC Health Services Research, 24(1), Article 264. https://doi.org/10.1186/s12913-024-10760-3

The introduction of Integrated Care Systems (ICS) in England aimed to increase joint planning and delivery of health and social care, and other services, to better meet the needs of local communities. There is an associated duty to undertake collabor... Read More about “We have to change our mindsets”: a qualitative study of barriers and facilitators in research collaboration across integrated care system organisations.

Exploring the potential extended role of community pharmacy in the management of osteoarthritis: A multi‐methods study with pharmacy staff and other healthcare professionals (2024)
Journal Article
Simkins, J., Holden, M. A., Babatunde, O., White, S., Nicholls, E., Long, A., …O’Brien, N. (2024). Exploring the potential extended role of community pharmacy in the management of osteoarthritis: A multi‐methods study with pharmacy staff and other healthcare professionals. Musculoskeletal Care, 22(1), Article e1873. https://doi.org/10.1002/msc.1873

Introduction Osteoarthritis is the commonest form of chronic joint pain, which patients often self-manage before seeking healthcare advice. Patients frequently seek advice from community pharmacies, and a recent policy has recommended integrating co... Read More about Exploring the potential extended role of community pharmacy in the management of osteoarthritis: A multi‐methods study with pharmacy staff and other healthcare professionals.