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Trends in Incidence and Prevalence of Osteoarthritis in the United Kingdom: Findings from the Clinical Practice Research Datalink (CPRD) (2020)
Journal Article
Mallen. (2020). Trends in Incidence and Prevalence of Osteoarthritis in the United Kingdom: Findings from the Clinical Practice Research Datalink (CPRD). Osteoarthritis and Cartilage, 792-801. https://doi.org/10.1016/j.joca.2020.03.004

Objective: This study aimed to explore the incidence and prevalence of OA in the UK in 2017 and their trends from 1997 to 2017 using a large nationally representative primary care database. Design: The UK Clinical Practice Research Datalink (CPRD)... Read More about Trends in Incidence and Prevalence of Osteoarthritis in the United Kingdom: Findings from the Clinical Practice Research Datalink (CPRD).

Interstitial lung disease is a risk factor for ischaemic heart disease and myocardial infarction (2020)
Journal Article
Elise Clarson, L., Bajpai, R., Whittle, R., Belcher, J., Abdul Sultan, A., Shing Kwok, C., …Mallen, C. D. (2020). Interstitial lung disease is a risk factor for ischaemic heart disease and myocardial infarction. Heart, Article 12. https://doi.org/10.1136/heartjnl-2019-315511

Objectives Despite many shared risk factors and pathophysiological pathways, the risk of ischaemic heart disease (IHD) and myocardial infarction (MI) in interstitial lung disease (ILD) remains poorly understood. This lack of data could be preventing... Read More about Interstitial lung disease is a risk factor for ischaemic heart disease and myocardial infarction.

Interstitial lung disease is a risk factor for ischaemic heart disease and myocardial infarction. (2020)
Journal Article
Mallen, C., Belcher, J., Mamas, M., Clarson, L., Welsh, V., & Bajpai, R. (2020). Interstitial lung disease is a risk factor for ischaemic heart disease and myocardial infarction. Heart, 916-922. https://doi.org/10.1136/heartjnl-2019-315511

OBJECTIVES: Despite many shared risk factors and pathophysiological pathways, the risk of ischaemic heart disease (IHD) and myocardial infarction (MI) in interstitial lung disease (ILD) remains poorly understood. This lack of data could be preventing... Read More about Interstitial lung disease is a risk factor for ischaemic heart disease and myocardial infarction..

Comorbidities in patients with polymyalgia rheumatica prior to and following diagnosis: A case control and cohort study (2020)
Journal Article
Partington, R., Muller, S., Mallen, C. D., Abdul Sultan, A., & Helliwell, T. (2020). Comorbidities in patients with polymyalgia rheumatica prior to and following diagnosis: A case control and cohort study. Seminars in Arthritis and Rheumatism, 50(4), 663-672. https://doi.org/10.1016/j.semarthrit.2020.05.003

Objectives: To determine the burden of comorbidities, including glucocorticoid (GC) related adverse effects, in patients with polymyalgia rheumatica (PMR) before and after diagnosis. Methods: We extracted anonymised electronic medical records of p... Read More about Comorbidities in patients with polymyalgia rheumatica prior to and following diagnosis: A case control and cohort study.

Development and validation of the DIabetes Severity SCOre (DISSCO) in 139 626 individuals with type 2 diabetes: a retrospective cohort study. (2020)
Journal Article
Mamas, Chew-Graham, & Mallen. (2020). Development and validation of the DIabetes Severity SCOre (DISSCO) in 139 626 individuals with type 2 diabetes: a retrospective cohort study. BMJ Open Diabetes Research and Care, https://doi.org/10.1136/bmjdrc-2019-000962

OBJECTIVE: Clinically applicable diabetes severity measures are lacking, with no previous studies comparing their predictive value with glycated hemoglobin (HbA1c). We developed and validated a type 2 diabetes severity score (the DIabetes Severity SC... Read More about Development and validation of the DIabetes Severity SCOre (DISSCO) in 139 626 individuals with type 2 diabetes: a retrospective cohort study..

Family medicine in times of 'COVID-19': A generalists' voice. (2020)
Journal Article
Mallen. (2020). Family medicine in times of 'COVID-19': A generalists' voice. European Journal of General Practice, 58 - 60. https://doi.org/10.1080/13814788.2020.1757312

The novel coronavirus epidemic is transforming the world in which we live. This pandemic will bring sweeping changes everywhere, not least in the field of primary care medicine. Like one of our colleagues said: ‘after this crisis, perhaps even our c... Read More about Family medicine in times of 'COVID-19': A generalists' voice..

THE RELATIONSHIP BETWEEN OBESITY AND OUTCOMES IN PATIENTS WITH POLYMYALGIA RHEUMATICA (2020)
Journal Article
Helliwell, T., Mallen, C. D., Scott, I. C., Bajpai, R., Muller, S., & Hider, S. L. (2020). THE RELATIONSHIP BETWEEN OBESITY AND OUTCOMES IN PATIENTS WITH POLYMYALGIA RHEUMATICA. Rheumatology, 59, 18-18. https://doi.org/10.1093/RHEUMATOLOGY/KEAA110.037

Background Obesity predisposes to a pro-inflammatory state. Studies have reported worse clinical outcomes in patients with inflammatory arthritis who are obese. The relationship between obesity and outcomes in patients with polymyalgia rheumatica (P... Read More about THE RELATIONSHIP BETWEEN OBESITY AND OUTCOMES IN PATIENTS WITH POLYMYALGIA RHEUMATICA.

The relationship between obesity and outcomes in patients with polymyalgia rheumatica (2020)
Presentation / Conference
Scott, I. C., Bajpai, R., Mallen, C., Muller, S., Helliwell, T., & Hider, S. (2020, April). The relationship between obesity and outcomes in patients with polymyalgia rheumatica. Presented at British Society for Rheumatology Annual Conference 2020, Scottish Event Campus (SEC), Scotland, UK

Background Obesity predisposes to a pro-inflammatory state. Studies have reported worse clinical outcomes in patients with inflammatory arthritis who are obese. The relationship between obesity and outcomes in patients with polymyalgia rheumatica (P... Read More about The relationship between obesity and outcomes in patients with polymyalgia rheumatica.

Qualitative findings from the Hip Injection Trial (HIT): experiences of living with hip osteoarthritis and receiving trial treatments (2020)
Journal Article
Paskins, Holden, Mallen, Jinks, Hawarden, & Roddy. (2020). Qualitative findings from the Hip Injection Trial (HIT): experiences of living with hip osteoarthritis and receiving trial treatments. Rheumatology, https://doi.org/10.1093/rheumatology/keaa111.125

Background The HIT trial compared ultrasound-guided intra-articular hip injection (USGI) of triamcinolone acetonide and 1% lidocaine hydrochloride combined with best current treatment (BCT) with (i) BCT alone and (ii) an USGI of 1% lidocaine only co... Read More about Qualitative findings from the Hip Injection Trial (HIT): experiences of living with hip osteoarthritis and receiving trial treatments.

CLINICAL AND COST-EFFECTIVENESS OF ULTRASOUND-GUIDED INTRA-ARTICULAR CORTICOSTEROID AND LOCAL ANAESTHETIC INJECTION FOR HIP OSTEOARTHRITIS: A RANDOMISED CONTROLLED TRIAL (HIT) (2020)
Journal Article
Paskins, Z., Bromley, K., Lewis, M., Hughes, G., Hughes, E., Cherrington, A., …Roddy, E. (2020). CLINICAL AND COST-EFFECTIVENESS OF ULTRASOUND-GUIDED INTRA-ARTICULAR CORTICOSTEROID AND LOCAL ANAESTHETIC INJECTION FOR HIP OSTEOARTHRITIS: A RANDOMISED CONTROLLED TRIAL (HIT). Osteoarthritis and Cartilage, 28(S1), https://doi.org/10.1016/j.joca.2020.02.751

Undertaking an integrated nurse led review (INCLUDE) for patients with inflammatory conditions: does it change management of morbidities? (2020)
Journal Article
Healey, E., Chew-Graham, C., Finney, A., Cooke, K., Wathall, S., Mallen, C., …Jinks, C. (2020). Undertaking an integrated nurse led review (INCLUDE) for patients with inflammatory conditions: does it change management of morbidities?. Rheumatology, https://doi.org/10.1093/rheumatology/keaa111.141

Background People with inflammatory rheumatological conditions (IRCs), including rheumatoid arthritis (RA), ankylosing spondylitis (AS), psoriatic arthritis (PsA), polymyalgia rheumatica (PMR) and giant cell arteritis (GCA), are at an increased risk... Read More about Undertaking an integrated nurse led review (INCLUDE) for patients with inflammatory conditions: does it change management of morbidities?.

P148 Gastrointestinal symptoms and proton pump inhibitor use in patients with polymyalgia rheumatica: results from the PMR Cohort study (2020)
Presentation / Conference
Feddah, H., Muller, S., Hider, S., Hay, C., & Mallen, C. (2020, April). P148 Gastrointestinal symptoms and proton pump inhibitor use in patients with polymyalgia rheumatica: results from the PMR Cohort study. Poster presented at British Society for Rheumatology Annual Conference 2020, - Cancelled -

Background Polymyalgia Rheumatica (PMR) is a common disorder of older adults, characterised by pain and stiffness in the shoulders and hips. PMR is one of the commonest indications for long-term glucocorticoid use. Because of the well-recognised sid... Read More about P148 Gastrointestinal symptoms and proton pump inhibitor use in patients with polymyalgia rheumatica: results from the PMR Cohort study.

The hip injection trial (HIT) nested qualitative study: experiences of living with hip Osteoarthritis and receiving trial treatments. (2020)
Journal Article
Holden, M., Hawarden, A., Paskins, Z., Roddy, E., Mallen, C., Jinks, C., & Trial Team, T. H. (2020). The hip injection trial (HIT) nested qualitative study: experiences of living with hip Osteoarthritis and receiving trial treatments. Osteoarthritis and Cartilage, 28, S499. https://doi.org/10.1016/j.joca.2020.02.782

Purpose: Evidence about the effectiveness of intra-articular corticosteroid injection for hip osteoarthritis (OA) is limited. The HIT trial compared ultrasound-guided intra-articular hip injection (USGI) of triamcinolone acetonide and 1% lidocaine hy... Read More about The hip injection trial (HIT) nested qualitative study: experiences of living with hip Osteoarthritis and receiving trial treatments..

Temporal relationship between osteoarthritis and comorbidities: a combined case control and cohort study in the United Kingdom primary care setting (2020)
Journal Article
Swain, S., Coupland, C., Mallen, C., Kuo, C. F., Sarmanova, A., Doherty, M., & Zhang, W. (2020). Temporal relationship between osteoarthritis and comorbidities: a combined case control and cohort study in the United Kingdom primary care setting. Osteoarthritis and Cartilage, 28, S72-S73. https://doi.org/10.1016/j.joca.2020.02.110

Purpose: To determine the temporal relationship between osteoarthritis (OA) and comorbidities. Methods: During a 20 years period (1997-2017), we identified 222,290 incident OA cases and 222,290 age (+/-2 years), sex and practice matched controls (... Read More about Temporal relationship between osteoarthritis and comorbidities: a combined case control and cohort study in the United Kingdom primary care setting.

O04 Clinical and cost-effectiveness of ultrasound-guided intra-articular corticosteroid and local anaesthetic injection for hip OA: a randomised controlled trial (HIT) (2020)
Presentation / Conference
Paskins, Z., Bromley, K., Lewis, M., Hughes, G., Hughes, E., Cherrington, A., …Roddy, E. (2020, April). O04 Clinical and cost-effectiveness of ultrasound-guided intra-articular corticosteroid and local anaesthetic injection for hip OA: a randomised controlled trial (HIT). Presented at British Society for Rheumatology Annual Conference 2020, Glasgow, Scotland, UK

Background Evidence of the effectiveness of intra-articular corticosteroid injection for hip osteoarthritis (OA) is limited. The HIT trial compared the clinical and cost-effectiveness of an ultrasound-guided intra-articular hip injection (USGI) of 4... Read More about O04 Clinical and cost-effectiveness of ultrasound-guided intra-articular corticosteroid and local anaesthetic injection for hip OA: a randomised controlled trial (HIT).

P197 Analgesic prescribing in patients with inflammatory arthritis in the NHS (2020)
Journal Article
Scott, I. C., Bailey, J., White, C., Mallen, C. D., & Muller, S. (2020). P197 Analgesic prescribing in patients with inflammatory arthritis in the NHS. Rheumatology, 59(Supplement_2), https://doi.org/10.1093/rheumatology/keaa111.192

Background There is little evidence analgesics improve pain in inflammatory arthritis (IA), and substantial evidence they have significant harms. Excepting NSAIDs in ankylosing spondylitis (AS), their long-term use is not recommended in guidelines.... Read More about P197 Analgesic prescribing in patients with inflammatory arthritis in the NHS.

P142 Factors associated with change in health-related quality of life in people living with gout: a three-year prospective cohort study in primary care (2020)
Journal Article
Watson, L., Belcher, J., Nicholls, E., Chandratre, P., Blagojevic-Bucknall, M., Hider, S., …Roddy, E. (2020). P142 Factors associated with change in health-related quality of life in people living with gout: a three-year prospective cohort study in primary care. Rheumatology, 59(Supplement_2), https://doi.org/10.1093/rheumatology/keaa111.137

Background Gout affects 2.5% of adults in the UK but is often poorly managed. It can impair health-related quality of life (HRQOL), yet little is known about which people with gout are at risk of worse outcomes. We investigated factors associated wi... Read More about P142 Factors associated with change in health-related quality of life in people living with gout: a three-year prospective cohort study in primary care.

Cardiovascular risk factors and outcomes in early rheumatoid arthritis: a population-based study (2020)
Journal Article
Mallen. (2020). Cardiovascular risk factors and outcomes in early rheumatoid arthritis: a population-based study. Heart, https://doi.org/10.1136/heartjnl-2019-316193

Objective To assess the burden of cardiovascular disease (CVD) at and prior to diagnosis in people with early rheumatoid arthritis (RA) and subsequent CVD in these patients. Methods A retrospective case–control study using a large English primary... Read More about Cardiovascular risk factors and outcomes in early rheumatoid arthritis: a population-based study.

Trends in incidence and prevalence of osteoarthritis in the United Kingdom: findings from the Clinical Practice Research Datalink (CPRD). (2020)
Journal Article
Mallen. (2020). Trends in incidence and prevalence of osteoarthritis in the United Kingdom: findings from the Clinical Practice Research Datalink (CPRD). Osteoarthritis and Cartilage, https://doi.org/10.1016/j.joca.2020.03.004

OBJECTIVE: This study aimed to explore the incidence and prevalence of OA in the UK in 2017 and their trends from 1997 to 2017 using a large nationally representative primary care database. DESIGN: The UK Clinical Practice Research Datalink (CPRD) co... Read More about Trends in incidence and prevalence of osteoarthritis in the United Kingdom: findings from the Clinical Practice Research Datalink (CPRD)..