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All Outputs (52)

Prevalence of osteoarthritis in lower middle- and low-income countries: a systematic review and meta-analysis (2021)
Journal Article
Yahaya, I., Wright, T., Babatunde, O., Corp, N., Helliwell, T., Dikomitis, L., & Mallen, C. (2021). Prevalence of osteoarthritis in lower middle- and low-income countries: a systematic review and meta-analysis. Rheumatology International, 41, 1221-1231. https://doi.org/10.1007/s00296-021-04838-y

Evidence from the Global Burden of Disease studies suggests that osteoarthritis (OA) is a significant cause of disability globally; however, it is less clear how much of this burden exists in low-income and lower middle-income countries. This study a... Read More about Prevalence of osteoarthritis in lower middle- and low-income countries: a systematic review and meta-analysis.

Propranolol Reduces Risk of Knee or Hip Replacement Due to Osteoarthritis: a Propensity Score Matched Cohort Study-using Data From the Clinical Practice Research Datalink. (2021)
Journal Article
Mamas, M., & Mallen, C. (2021). Propranolol Reduces Risk of Knee or Hip Replacement Due to Osteoarthritis: a Propensity Score Matched Cohort Study-using Data From the Clinical Practice Research Datalink. Research Square, https://doi.org/10.21203/rs.3.rs-670522/v1

Objectives: To examine the association between ß -blocker prescription and knee or hip total joint replacement (TJR) in a UK primary-care population with incident knee or hip osteoarthritis (OA). Methods: Cohort study using data from the Clinical P... Read More about Propranolol Reduces Risk of Knee or Hip Replacement Due to Osteoarthritis: a Propensity Score Matched Cohort Study-using Data From the Clinical Practice Research Datalink..

Mortality in Patients With Gout Treated With Allopurinol: A Systematic Review and Meta‐Analysis (2021)
Journal Article
Hay, C. A., Prior, J. A., Belcher, J., Mallen, C. D., & Roddy, E. (2021). Mortality in Patients With Gout Treated With Allopurinol: A Systematic Review and Meta‐Analysis. Arthritis Care & Research, 73(7), 1049-1054. https://doi.org/10.1002/acr.24205

ObjectiveUrate‐lowering therapy (predominantly allopurinol) is highly effective as a treatment for gout, but its wider long‐term effects remain unclear. This systematic review and meta‐analysis aimed to ascertain the association between mortality and... Read More about Mortality in Patients With Gout Treated With Allopurinol: A Systematic Review and Meta‐Analysis.

Refinement and validation of a tool for stratifying patients with musculoskeletal pain (2021)
Journal Article
Dunn, K. M., Campbell, P., Lewis, M., Hill, J. C., van der Windt, D. A., Afolabi, E., …Foster, N. E. (2021). Refinement and validation of a tool for stratifying patients with musculoskeletal pain. European Journal of Pain, 25(10), 2081-2093. https://doi.org/10.1002/ejp.1821

AbstractBackgroundPatients with musculoskeletal pain in different body sites share common prognostic factors. Using prognosis to stratify and treatment match can be clinically and cost‐effective. We aimed to refine and validate the Keele STarT MSK To... Read More about Refinement and validation of a tool for stratifying patients with musculoskeletal pain.

Missed opportunities in coronary artery disease: reflection on practice to improve patient outcomes (2021)
Journal Article
Kwok, C. S., Satchithananda, D., & Mallen, C. D. (2021). Missed opportunities in coronary artery disease: reflection on practice to improve patient outcomes. Coronary Artery Disease, 33(3), 233-238. https://doi.org/10.1097/MCA.0000000000001075

Missed opportunities refer to incidents where different actions by those involved could result in more desirable outcomes. While missed opportunities is not an established concept in coronary artery disease (CAD), they are important because CAD is co... Read More about Missed opportunities in coronary artery disease: reflection on practice to improve patient outcomes.

Missed acute myocardial infarction: an underrecognized problem that contributes to poor patient outcomes. (2021)
Journal Article
Mallen. (2021). Missed acute myocardial infarction: an underrecognized problem that contributes to poor patient outcomes. Coronary Artery Disease, 345-349. https://doi.org/10.1097/MCA.0000000000000975

Ischemic heart disease is the number one killer in the world. While improvements in the management of acute myocardial infarction (AMI) have resulted in lower mortality rates, there are still cases where AMI is missed with rates varying depending on... Read More about Missed acute myocardial infarction: an underrecognized problem that contributes to poor patient outcomes..

Misdiagnosis of heart failure: A systematic review of the literature (2021)
Journal Article
Mallen. (2021). Misdiagnosis of heart failure: A systematic review of the literature. Journal of Cardiac Failure, 925-933. https://doi.org/10.1016/j.cardfail.2021.05.014

Background Heart failure (HF) is a chronic disease associated with a significant burden to patients, families and health services. The diagnosis of HF can be easily missed due to similar symptoms with other conditions especially respiratory diseases... Read More about Misdiagnosis of heart failure: A systematic review of the literature.

Corrigendum to: comparing the use of direct observation, standardized patients and exit interviews in low- and middle-income countries: a systematic review of methods of assessing quality of primary care. (2021)
Journal Article
Mallen. (2021). Corrigendum to: comparing the use of direct observation, standardized patients and exit interviews in low- and middle-income countries: a systematic review of methods of assessing quality of primary care. Health Policy and Planning, 341-356. https://doi.org/10.1093/heapol/czab046

PREVALENCE OF FRAGILITY FRACTURES AND MEDICATION PRESCRIPTION FOR OSTEOPOROSIS IN PATIENTS WITH POLYMYALGIA RHEUMATICA: RESULTS FROM THE PMR COHORT STUDY (2021)
Journal Article
Singh Sokhal, B., Hider, S. L., Paskins, Z., Muller, S., & Mallen, C. D. (2021). PREVALENCE OF FRAGILITY FRACTURES AND MEDICATION PRESCRIPTION FOR OSTEOPOROSIS IN PATIENTS WITH POLYMYALGIA RHEUMATICA: RESULTS FROM THE PMR COHORT STUDY. Rheumatology, 60(S1), Article ARTN keab246.002. https://doi.org/10.1093/rheumatology/keab246.002

Background/Aims Polymyalgia rheumatica (PMR) is one of the commonest indications for long term glucocorticoid (GC) use, leading to an increased risk of osteoporosis and fragility fractures. Clinical guidelines recommend prescribing medication includ... Read More about PREVALENCE OF FRAGILITY FRACTURES AND MEDICATION PRESCRIPTION FOR OSTEOPOROSIS IN PATIENTS WITH POLYMYALGIA RHEUMATICA: RESULTS FROM THE PMR COHORT STUDY.

The patient, clinician and healthcare perspectives in evaluating care pathways for stable chest pain. (2021)
Journal Article
Kwok, C. S., Duckett, S., Satchithananda, D., Potluri, R., Morgan-Smith, D., Bellenger, N., …Mallen, C. D. (2021). The patient, clinician and healthcare perspectives in evaluating care pathways for stable chest pain. Critical Pathways in Cardiology: A Journal of Evidence-Based Medicine, 20(3), 143-148. https://doi.org/10.1097/HPC.0000000000000261

Chest pain is one of the most common reasons for patients to present to healthcare professionals. One of the main challenges with the management of chest pain is the wide differential diagnosis, ranging from minor chest trauma to potentially life thr... Read More about The patient, clinician and healthcare perspectives in evaluating care pathways for stable chest pain..

Assessing the severity of cardiovascular disease in 213 088 patients with coronary heart disease: a retrospective cohort study. (2021)
Journal Article
Mamas, Mallen, & Chew-Graham. (2021). Assessing the severity of cardiovascular disease in 213 088 patients with coronary heart disease: a retrospective cohort study. Open Heart, https://doi.org/10.1136/openhrt-2020-001498

OBJECTIVE: Most current cardiovascular disease (CVD) risk stratification tools are for people without CVD, but very few are for prevalent CVD. In this study, we developed and validated a CVD severity score in people with coronary heart disease (CHD)... Read More about Assessing the severity of cardiovascular disease in 213 088 patients with coronary heart disease: a retrospective cohort study..

Impact of changes to national guidelines on hypertension-related workload: an interrupted time series analysis in English primary care. (2021)
Journal Article
Mallen. (2021). Impact of changes to national guidelines on hypertension-related workload: an interrupted time series analysis in English primary care. British Journal of General Practice (BJGP), e296-e302. https://doi.org/10.3399/bjgp21X714281

BACKGROUND: In 2011, National Institute for Health and Care Excellence (NICE) guidelines recommended the routine use of out-of-office blood pressure (BP) monitoring for the diagnosis of hypertension. These changes were predicted to reduce unnecessary... Read More about Impact of changes to national guidelines on hypertension-related workload: an interrupted time series analysis in English primary care..

Self-management advice, exercise and foot orthoses for plantar heel pain: the TREADON pilot and feasibility randomised trial (2021)
Journal Article
Chesterton, L. S., Thomas, M. J., Hendry, G., Chen, Y., Goddin, D., Halliday, N., …Roddy, E. (2021). Self-management advice, exercise and foot orthoses for plantar heel pain: the TREADON pilot and feasibility randomised trial. Pilot and Feasibility Studies, 7, Article 92. https://doi.org/10.1186/s40814-021-00808-0

Plantar heel pain (PHP) is common and impacts negatively on physical function and quality of life. Initial treatment usually comprises analgesia and self-management advice (SMA), with referral to a physiotherapist or podiatrist recommended only when... Read More about Self-management advice, exercise and foot orthoses for plantar heel pain: the TREADON pilot and feasibility randomised trial.

Clinical and cost-effectiveness of bracing in symptomatic knee osteoarthritis management: protocol for a multicentre, primary care, randomised, parallel-group, superiority trial. (2021)
Journal Article
Holden, M., Callaghan, M., Felson, D., Birrell, F., Nicholls, E., Jowett, S., …Peat, G. (2021). Clinical and cost-effectiveness of bracing in symptomatic knee osteoarthritis management: protocol for a multicentre, primary care, randomised, parallel-group, superiority trial. BMJ Open, 11(3), Article e048196. https://doi.org/10.1136/bmjopen-2020-048196

BACKGROUND: Brace effectiveness for knee osteoarthritis (OA) remains unclear and international guidelines offer conflicting recommendations. Our trial will determine the clinical and cost-effectiveness of adding knee bracing (matched to patients' cli... Read More about Clinical and cost-effectiveness of bracing in symptomatic knee osteoarthritis management: protocol for a multicentre, primary care, randomised, parallel-group, superiority trial..

Developing a model Fracture Liaison Service consultation with patients, carers and clinicians: a Delphi survey to inform content of the iFraP complex consultation intervention. (2021)
Journal Article
Bullock, L., Crawford-Manning, F., Cottrell, E., Fleming, J., Leyland, S., Edwards, J., …Paskins, Z. (2021). Developing a model Fracture Liaison Service consultation with patients, carers and clinicians: a Delphi survey to inform content of the iFraP complex consultation intervention. Archives of Osteoporosis, 16, 1- 17. https://doi.org/10.1007/s11657-021-00913-w

Fracture Liaison Services are recommended to deliver best practice in secondary fracture prevention. This modified Delphi survey, as part of the iFraP (Improving uptake of Fracture Prevention drug Treatments) study, provides consensus regarding tasks... Read More about Developing a model Fracture Liaison Service consultation with patients, carers and clinicians: a Delphi survey to inform content of the iFraP complex consultation intervention..

Onset of comorbidities and flare patterns within pre-existing morbidity clusters in people with gout: 5-year primary care cohort study. (2021)
Journal Article
Bajpai, R., Muller, S., Mallen, C., Watson, L., Richette, P., Hider, S. L., & Roddy, E. (2021). Onset of comorbidities and flare patterns within pre-existing morbidity clusters in people with gout: 5-year primary care cohort study. Rheumatology, 61(1), 407-412. https://doi.org/10.1093/rheumatology/keab283

OBJECTIVE: To investigate the onset of comorbidities and pattern of flares over five years according to baseline comorbidity clusters in people with gout. METHODS: In a prospective primary-care-based cohort study, adults aged =18 years with gout, wer... Read More about Onset of comorbidities and flare patterns within pre-existing morbidity clusters in people with gout: 5-year primary care cohort study..

What is the incidence of methotrexate or leflunomide discontinuation related to cytopenia, liver enzyme elevation or kidney function decline? (2021)
Journal Article
Mallen. (2021). What is the incidence of methotrexate or leflunomide discontinuation related to cytopenia, liver enzyme elevation or kidney function decline?. Rheumatology, https://doi.org/10.1093/rheumatology/keab254

OBJECTIVES: To examine incidence of treatment changes due to abnormal blood-test results and, to explore rates of treatment changes due to liver, kidney and haematological blood-test abnormalities in autoimmune rheumatic diseases (AIRD) treated with... Read More about What is the incidence of methotrexate or leflunomide discontinuation related to cytopenia, liver enzyme elevation or kidney function decline?.

Exploring patient views of empathic optimistic communication for osteoarthritis in primary care: A qualitative interview study using vignettes (2021)
Journal Article
Mallen. (2021). Exploring patient views of empathic optimistic communication for osteoarthritis in primary care: A qualitative interview study using vignettes. British Journal of General Practice Open (BJGP Open), https://doi.org/10.3399/BJGPO.2021.0014

BACKGROUND: Osteoarthritis (OA) causes pain and disability. An empathic optimistic consultation approach can improve patient quality of life, satisfaction with care, and reduce pain. However, expressing empathic optimism may be overlooked in busy pri... Read More about Exploring patient views of empathic optimistic communication for osteoarthritis in primary care: A qualitative interview study using vignettes.

ß-blocker prescription is associated with lower cumulative risk of knee osteoarthritis and knee pain consultations in primary care: a propensity score matched cohort study (2021)
Journal Article
Mamas, & Mallen. (2021). ß-blocker prescription is associated with lower cumulative risk of knee osteoarthritis and knee pain consultations in primary care: a propensity score matched cohort study. Rheumatology, https://doi.org/10.1093/rheumatology/keab234

OBJECTIVES: To examine the association between ß-blocker prescription and first primary-care consultation for knee osteoarthritis (OA), hip OA, knee pain and hip pain. METHODS: Data source: Clinical Practice Research Datalink. Participants aged =40?y... Read More about ß-blocker prescription is associated with lower cumulative risk of knee osteoarthritis and knee pain consultations in primary care: a propensity score matched cohort study.